Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis

The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal

(2017) Jason E. Hawkes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics

(2016) H. Kang et al.   BRITISH JOURNAL OF DERMATOLOGY

Metabolic Heterogeneity in Human Lung Tumors

(2016) Christopher T. Hensley et al.   CELL

Glutathione Depletion, Pentose Phosphate Pathway Activation, and Hemolysis in Erythrocytes Protecting Cancer Cells from Vitamin C-induced Oxidative Stress

(2016) Zhuzhen Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Psoriasis

(2016) Jacqueline E. Greb et al.   Nature Reviews Disease Primers

The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1

(2015) Wilhelm Palm et al.   CELL

Nrf2—A regulator of keratinocyte redox signaling

(2015) Matthias Schäfer et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

(2015) Eunice E. Lee et al.   MOLECULAR CELL

Acute Activation of Oxidative Pentose Phosphate Pathway as First-Line Response to Oxidative Stress in Human Skin Cells

(2015) Andreas Kuehne et al.   MOLECULAR CELL

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

LC–MS Metabolomics of Psoriasis Patients Reveals Disease Severity-Dependent Increases in Circulating Amino Acids That Are Ameliorated by Anti-TNFα Treatment

(2014) Muhammad Anas Kamleh et al.   JOURNAL OF PROTEOME RESEARCH

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differentiation of epidermal keratinocytes is dependent on glucosylceramide:ceramide processing

(2013) Nicole Amen et al.   HUMAN MOLECULAR GENETICS

Glucose transporter member 1 is involved in UVB-induced epidermal hyperplasia by enhancing proliferation in epidermal keratinocytes

(2013) Takumi Tochio et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The mouse excisional wound splinting model, including applications for stem cell transplantation

(2013) Xusheng Wang et al.   Nature Protocols

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Psoriasiform dermatitis is driven by IL-36–mediated DC-keratinocyte crosstalk

(2012) Luigi Tortola et al.   JOURNAL OF CLINICAL INVESTIGATION

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

(2012) Sucheta Telang et al.   Journal of Translational Medicine

A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo

(2012) Y. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Systemic and Vascular Inflammation in Patients With Moderate to Severe Psoriasis as Measured by [18F]-Fluorodeoxyglucose Positron Emission Tomography –Computed Tomography (FDG-PET/CT)

(2011) Nehal N. Mehta   ARCHIVES OF DERMATOLOGY

IL-22 Is Required for Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

(2011) A. B. Van Belle et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma

(2011) S A Watt et al.   ONCOGENE

Glucose transporters in the 21st Century

(2009) Bernard Thorens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

(2009) L. van der Fits et al.   JOURNAL OF IMMUNOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension

(2008) Sharon Barone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of GLUT-1 in psoriasis and the relationship between GLUT-1 upregulation induced by hypoxia and proliferation of keratinocyte growth

(2008) Juan Tao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

(2008) Ulrike Lichti et al.   Nature Protocols