Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

Chemical Biology Probes from Advanced DNA-encoded Libraries

(2016) Hazem Salamon et al.   ACS Chemical Biology

Novel PTP1B inhibitors identified by DNA display of fragment pairs

(2016) Sofia Barluenga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemical Space of DNA-Encoded Libraries

(2016) Raphael M. Franzini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated screening for small organic ligands using DNA-encoded chemical libraries

(2016) Willy Decurtins et al.   Nature Protocols

DNA-encoded chemistry: enabling the deeper sampling of chemical space

(2016) Robert A. Goodnow et al.   NATURE REVIEWS DRUG DISCOVERY

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure–Activity Relationships

(2016) Alexander L. Satz   ACS Combinatorial Science

Optimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial Libraries

(2016) Yizhou Li et al.   ACS Combinatorial Science

DNA-Encoded Dynamic Combinatorial Chemical Libraries

(2015) Francesco V. Reddavide et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

(2015) Moreno Wichert et al.   Nature Chemistry

Design, preparation, and selection of DNA-encoded dynamic libraries

(2015) Gang Li et al.   Chemical Science

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

(2015) J.-P. Daguer et al.   Chemical Science

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library

(2015) Hongfeng Deng et al.   ACS Medicinal Chemistry Letters

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

(2015) Alexander Litovchick et al.   Scientific Reports

A Small-Molecule Drug Conjugate for the Treatment of Carbonic Anhydrase IX Expressing Tumors

(2014) Nikolaus Krall et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systematic Evaluation and Optimization of Modification Reactions of Oligonucleotides with Amines and Carboxylic Acids for the Synthesis of DNA-Encoded Chemical Libraries

(2014) Raphael M. Franzini et al.   BIOCONJUGATE CHEMISTRY

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Multistep DNA-Templated Synthesis Using a Universal Template

(2013) Yizhou Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo

(2013) Greg M. Thurber et al.   Nature Communications

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diverse backbone-cyclized peptides via codon reprogramming

(2009) Takashi Kawakami et al.   Nature Chemical Biology

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA