Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

Protocols for Molecular Modeling with Rosetta3 and RosettaScripts

(2016) Brian J. Bender et al.   BIOCHEMISTRY

A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2 R Antagonists

(2016) Kerstin Burkert et al.   ChemMedChem

Mimicking of Arginine by Functionalized Nω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples

(2016) Max Keller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

(2016) Marina Casiraghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation mechanism of endothelin ETB receptor by endothelin-1

(2016) Wataru Shihoya et al.   NATURE

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

(2016) Jie Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

(2016) Jie Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2Receptor Binding and Activation

(2015) Anette Kaiser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nω-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([3H]UR-MK299) with Extended Residence Time

(2015) Max Keller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

(2014) Jie Yin et al.   NATURE

Mutagenesis and Computational Modeling of Human G-Protein-Coupled Receptor Y2 for Neuropeptide Y and Peptide YY

(2013) Bo Xu et al.   BIOCHEMISTRY

Pancreatic Polypeptide Is Recognized by Two Hydrophobic Domains of the Human Y4Receptor Binding Pocket

(2013) Xavier Pedragosa-Badia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

High-Resolution Comparative Modeling with RosettaCM

(2013) Yifan Song et al.   STRUCTURE

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of the agonist-bound neurotensin receptor

(2012) Jim F. White et al.   NATURE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Assessment of a Fully Active Class A G Protein-Coupled Receptor Isolated fromin VitroFolding

(2011) Mathias Bosse et al.   BIOCHEMISTRY

NPY receptors as potential targets for anti-obesity drug development

(2011) Ernie Yulyaningsih et al.   BRITISH JOURNAL OF PHARMACOLOGY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The neuropeptide Y system: Pathophysiological and therapeutic implications in obesity and cancer

(2011) Lei Zhang et al.   PHARMACOLOGY & THERAPEUTICS

Rosetta FlexPepDock ab-initio: Simultaneous Folding, Docking and Refinement of Peptides onto Their Receptors

(2011) Barak Raveh et al.   PLoS One

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A reconstitution protocol for the in vitro folded human G protein-coupled Y2 receptor into lipid environment

(2010) Peter Schmidt et al.   BIOPHYSICAL CHEMISTRY

A possible role of neuropeptide Y in depression and stress

(2009) Julio César Morales-Medina et al.   BRAIN RESEARCH

NPY Signalling Pathway in Bone Homeostasis: Y1 Receptor as a Potential Drug Target

(2009) D. Sousa et al.   CURRENT DRUG TARGETS

Functional role of the extracellular N-terminal domain of neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalization

(2008) D LINDNER et al.   CELLULAR SIGNALLING

Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist

(2008) Ildiko Antal-Zimanyi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Guanidine−Acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-LabeledNG-Propionylargininamide ([3H]-UR-MK114) as a Highly Potent and Selective Neuropeptide Y Y1Receptor Antagonist

(2008) Max Keller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

(2007) Christopher B. Roth et al.   JOURNAL OF MOLECULAR BIOLOGY