Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants

Total Biosynthesis of Antiangiogenic Agent (−)-Terpestacin by Artificial Reconstitution of the Biosynthetic Machinery in Aspergillus oryzae

(2018) Koji Narita et al.   JOURNAL OF ORGANIC CHEMISTRY

Identification of novel sesterterpenes by genome mining of phytopathogenic fungi Phoma and Colletotrichum sp.

(2018) Lei Gao et al.   TETRAHEDRON LETTERS

Theoretical Study of Sesterfisherol Biosynthesis: Computational Prediction of Key Amino Acid Residue in Terpene Synthase

(2018) Hajime Sato et al.   Scientific Reports

Modern Aspects of Isotopic Labellings in Terpene Biosynthesis

(2017) Jeroen S. Dickschat   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cyclization mechanism of phomopsene synthase: mass spectrometry based analysis of various site-specifically labeled terpenes

(2017) Sandip S Shinde et al.   JOURNAL OF ANTIBIOTICS

Sesteralterin and Tricycloalterfurenes A–D: Terpenes with Rarely Occurring Frameworks from the Marine-Alga-Epiphytic Fungus Alternaria alternata k21-1

(2017) Zhen-Zhen Shi et al.   JOURNAL OF NATURAL PRODUCTS

Releasing the potential power of terpene synthases by a robust precursor supply platform

(2017) Guangkai Bian et al.   METABOLIC ENGINEERING

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products

(2017) Koji Narita et al.   ORGANIC LETTERS

(+)-Thalianatriene and (−)-Retigeranin B Catalyzed by Sesterterpene Synthases from Arabidopsis thaliana

(2017) Jie Shao et al.   ORGANIC LETTERS

Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata

(2017) Miao Dong et al.   PLANTA MEDICA

Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution

(2017) Ancheng C. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase

(2016) Mengbin Chen et al.   ACS Chemical Biology

Astellifadiene: Structure Determination by NMR Spectroscopy and Crystalline Sponge Method, and Elucidation of its Biosynthesis

(2016) Yudai Matsuda et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Biosynthesis of Fungal Indole Diterpenes Using Cell Factories

(2016) Hideaki Oikawa et al.   HETEROCYCLES

Genome-Based Discovery of an Unprecedented Cyclization Mode in Fungal Sesterterpenoid Biosynthesis

(2016) Masahiro Okada et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Analyses of Short-Chain Prenyltransferases Identify an Evolutionarily Conserved GFPPS Clade in Brassicaceae Plants

(2016) Chengyuan Wang et al.   Molecular Plant

Bacterial terpene cyclases

(2016) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Multiple Oxidative Modifications in the Ophiobolin Biosynthesis: P450 Oxidations Found in Genome Mining

(2016) Koji Narita et al.   ORGANIC LETTERS

Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010

(2016) Zhaoming Liu et al.   ORGANIC LETTERS

An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping

(2015) Bin Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Unusual Terpene Cyclization Mechanism Involving a Carbon-Carbon Bond Rearrangement

(2015) Ayuko Meguro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host

(2015) Yuuki Yamada et al.   JOURNAL OF ANTIBIOTICS

Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes

(2015) Ying Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The energetic viability of an unexpected skeletal rearrangement in cyclooctatin biosynthesis

(2015) Young J. Hong et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases

(2015) Yudai Matsuda et al.   ORGANIC LETTERS

Tension between Internal and External Modes of Stabilization in Carbocations Relevant to Terpene Biosynthesis: Modulating Minima Depth via C–H···π Interactions

(2015) Young J. Hong et al.   ORGANIC LETTERS

“Cation-Stitching Cascade”: exquisite control of terpene cyclization in cyclooctatin biosynthesis

(2015) Hajime Sato et al.   Scientific Reports

Reconstructing fungal natural product biosynthetic pathways

(2014) C. M. Lazarus et al.   NATURAL PRODUCT REPORTS

Traversing the fungal terpenome

(2014) Maureen B. Quin et al.   NATURAL PRODUCT REPORTS

Terpene synthases are widely distributed in bacteria

(2014) Yuuki Yamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The first structure of a bacterial diterpene cyclase: CotB2

(2014) Ronja Janke et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pentalenene formation mechanisms redux

(2013) Michael W. Lodewyk et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus Aspergillus sp. 085242

(2013) Ze’en Xiao et al.   ORGANIC LETTERS

Identification of Ophiobolin F Synthase by a Genome Mining Approach: A Sesterterpene Synthase from Aspergillus clavatus

(2013) Ryota Chiba et al.   ORGANIC LETTERS

C–H⋯π interactions as modulators of carbocation structure – implications for terpene biosynthesis

(2013) Young J. Hong et al.   Chemical Science

Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis

(2010) Mustafa Köksal et al.   NATURE

Cloning and Heterologous Expression of the Cyclooctatin Biosynthetic Gene Cluster Afford a Diterpene Cyclase and Two P450 Hydroxylases

(2009) Seung-Young Kim et al.   CHEMISTRY & BIOLOGY

Biosynthetic Gene-Based Secondary Metabolite Screening: A New Diterpene, Methyl Phomopsenonate, from the FungusPhomopsis amygdali

(2009) Tomonobu Toyomasu et al.   JOURNAL OF ORGANIC CHEMISTRY

Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins

(2009) Tomonobu Toyomasu et al.   ORGANIC LETTERS

Recent Advances Regarding Diterpene Cyclase Genes in Higher Plants and Fungi

(2008) Tomonobu TOYOMASU   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY