Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment

(2017) Miao Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Nanoparticles-protein interaction: Role in protein aggregation and clinical implications

(2017) Romana Parveen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1

(2017) Wolfgang G. Kreyling et al.   Nanotoxicology

Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells

(2017) Parwathy Chandran et al.   Nanotoxicology

Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3

(2017) Wolfgang G. Kreyling et al.   Nanotoxicology

Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2

(2017) Wolfgang G. Kreyling et al.   Nanotoxicology

Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials

(2017) Glen M DeLoid et al.   Nature Protocols

Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples

(2017) Zhoumeng Lin et al.   TOXICOLOGICAL SCIENCES

Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver

(2017) Melvin E. Andersen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression

(2017) M.T. Ortega et al.   TOXICOLOGY IN VITRO

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles

(2016) Min Li et al.   AAPS Journal

Assessing exposure risks for freshwater tilapia species posed by mercury and methylmercury

(2016) Yi-Hsien Cheng et al.   ECOTOXICOLOGY

Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles

(2016) Yang Li et al.   Nanomedicine

A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles

(2016) Zhoumeng Lin et al.   Nanomedicine

Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity

(2016) Kyoungju Choi et al.   Nanotoxicology

The concept of bio-corona in modulating the toxicity of engineered nanomaterials (ENM)

(2016) Dana Westmeier et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils

(2016) Claudie Noël et al.   TOXICOLOGY IN VITRO

The applicability of conventional cytotoxicity assays to predict safety/toxicity of mesoporous silica nanoparticles, silver and gold nanoparticles and multi-walled carbon nanotubes

(2016) Marika Mannerström et al.   TOXICOLOGY IN VITRO

An Agent-Based Model of a Hepatic Inflammatory Response to Salmonella: A Computational Study under a Large Set of Experimental Data

(2016) Zhenzhen Shi et al.   PLoS One

Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation

(2015) Eileen D. Kuempel et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE

Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling

(2015) Faryad Darabi Sahneh et al.   Nanomedicine

Probabilistic modelling of prospective environmental concentrations of gold nanoparticles from medical applications as a basis for risk assessment

(2015) Indrani Mahapatra et al.   JOURNAL OF NANOBIOTECHNOLOGY

Toxicity and Biokinetics of Colloidal Gold Nanoparticles

(2015) Mi-Rae Jo et al.   Nanomaterials

Using physiologically based pharmacokinetic (PBPK) modeling for dietary risk assessment of titanium dioxide (TiO2) nanoparticles

(2014) Gerald Bachler et al.   Nanotoxicology

An integrated approach for the in vitro dosimetry of engineered nanomaterials

(2014) Joel M Cohen et al.   Particle and Fibre Toxicology

Pharmacokinetics of metallic nanoparticles

(2014) Zhoumeng Lin et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Air–Blood Barrier Translocation of Tracheally Instilled Gold Nanoparticles Inversely Depends on Particle Size

(2013) Wolfgang G. Kreyling et al.   ACS Nano

Of mice, men and nanoparticle biocoronas: arein vitrotoin vivocorrelations and interspecies extrapolations realistic?

(2013) Jim E Riviere   Nanomedicine

Structure–activity relationships for biodistribution, pharmacokinetics, and excretion of atomically precise nanoclusters in a murine model

(2013) O. Andrea Wong et al.   Nanoscale

Gold nanoparticles as novel agents for cancer therapy

(2012) S Jain et al.   BRITISH JOURNAL OF RADIOLOGY

Intrinsic therapeutic applications of noble metal nanoparticles: past, present and future

(2012) Rochelle R. Arvizo et al.   CHEMICAL SOCIETY REVIEWS

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

(2012) Helinor Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

In vivo toxicity, biodistribution, and clearance of glutathione-coated gold nanoparticles

(2012) Carrie A. Simpson et al.   Nanomedicine-Nanotechnology Biology and Medicine

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

(2011) Stephanie Hirn et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

(2011) Xiao-Dong Zhang et al.   International Journal of Nanomedicine

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

(2010) Nikolai Khlebtsov et al.   CHEMICAL SOCIETY REVIEWS

Interaction of engineered nanoparticles with various components of the environment and possible strategies for their risk assessment

(2010) Indu Bhatt et al.   CHEMOSPHERE

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies

(2010) Paul M Hinderliter et al.   Particle and Fibre Toxicology

PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals

(2010) Frédéric Y. Bois et al.   TOXICOLOGY

Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats

(2009) Suresh K. Balasubramanian et al.   BIOMATERIALS

To scale or not to scale: the principles of dose extrapolation

(2009) Vijay Sharma et al.   BRITISH JOURNAL OF PHARMACOLOGY

Assessment of the In Vivo Toxicity of Gold Nanoparticles

(2009) Yu-Shiun Chen et al.   Nanoscale Research Letters

Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles

(2009) Wan-Seob Cho et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Size and Concentration Effect of Gold Nanoparticles on X-ray Attenuation As Measured on Computed Tomography

(2008) Chenjie Xu et al.   CHEMISTRY OF MATERIALS

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

(2008) N.A. Monteiro-Riviere et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY