Article
Food Science & Technology
Nathalie De Beukelaer, Guido Weide, Ester Huyghe, Ines Vandekerckhove, Britta Hanssen, Nicky Peeters, Julie Uytterhoeven, Jorieke Deschrevel, Karen Maes, Marlies Corvelyn, Domiziana Costamagna, Ghislaine Gayan-Ramirez, Anja Van Campenhout, Kaat Desloovere
Summary: This study investigated the muscle growth in children with spastic cerebral palsy after receiving Botulinum Neurotoxin type-A (BoNT-A) injections. The results showed a significant decrease in cross-sectional muscle growth and an increase in echo-intensity six months post-BoNT-A injections compared to children who did not receive BoNT-A treatment.
Article
Clinical Neurology
Tugba Akinci D'Antonoli, Francesco Santini, Xeni Deligianni, Meritxell Garcia Alzamora, Erich Rutz, Oliver Bieri, Reinald Brunner, Claudia Weidensteiner
Summary: The study utilized a combination of MRI fat fraction and texture analysis to differentiate affected muscles from healthy ones in cerebral palsy patients, with the combination model consistently outperforming individual models in performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Andrew T. Hale, Oluwatoyin Akinnusotu, Jing He, Janey Wang, Natalie Hibshman, Chevis N. Shannon, Robert P. Naftel
Summary: This study is the first genome-wide association study of spastic CP, identifying a SNP (rs78686911) associated with CP by decreasing expression of GRIK4. The findings suggest that genetic variation contributes to the risk of CP.
Article
Clinical Neurology
Nathalie De Beukelaer, Lynn Bar-On, Britta Hanssen, Nicky Peeters, Sandra Prinsen, Els Ortibus, Kaat Desloovere, Anja Van Campenhout
Summary: Hereditary spastic paraplegia (HSP) is a neurological, genetic disorder characterized by lower limb spasticity and muscle weakness, similar to children with bilateral spastic cerebral palsy (SCP). Muscle data analysis revealed significant ankle clonus issues in children with HSP.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Stephanie Lee, Karyn Robinson, Madison Lodge, Mary Theroux, Freeman Miller, Robert Akins
Summary: Individuals with spastic cerebral palsy require higher doses of rocuronium for surgical intubation, with dosing influenced by GMFCS level, gestational age, and birthweight.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Clinical Neurology
Luh Karunia Wahyuni
Summary: Spastic quadriplegic cerebral palsy (CP) is a permanent neuromuscular disorder characterized by weak and inactive postural muscles, leading to atypical movement patterns and multisystem consequences that reduce the quality of life. The relationship between these factors has not yet been explored. Understanding of compensatory strategies and multisystem consequences offers the opportunity for early intervention to improve the quality of life for children with spastic quadriplegic CP.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Meta N. Eek, Jesper Augustsson, Roland Zugner, Roy Tranberg
Summary: This study aimed to investigate the feasibility and usefulness of measuring single-leg vertical jumping in young adults with cerebral palsy (CP). The results showed that this test was able to accurately measure jump height and power generation in individuals with CP, providing additional information about motor function.
Article
Dentistry, Oral Surgery & Medicine
Aysenur Tuncer, Asiye Uzun, Abidin H. Tuncer, Hazel C. Guzel, Elif D. Atilgan
Summary: This study aimed to evaluate the relationship between GMFCS score, age, bruxism, parafunctional oral habits, and oral motor problems in children with cerebral palsy. The study found that bruxism and the rate of parafunctional oral habits were high in children with spastic cerebral palsy, affecting oral motor activities. There was a relationship between oral motor problems and increased GMFCS levels, but no relationship was found between bruxism and GMFCS levels.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Veterinary Sciences
Namsoon Lee, Munsu Yun, Junghee Yoon
Summary: This study evaluated the cross-sectional area and fat infiltration of suboccipital muscles in normal and AAI dogs using MRI. Results showed that AAI dogs had smaller muscle area and greater fat infiltration compared to normal dogs. Dogs with mild neurological symptoms had higher fat infiltration than dogs with severe symptoms.
BMC VETERINARY RESEARCH
(2022)
Article
Neurosciences
Xiao-Kun Wang, Chao Gao, He-Quan Zhong, Xiang-Yu Kong, Rui Qiao, Hui-Chun Zhang, Bai-Yun Chen, Yang Gao, Bing Li
Summary: This study aimed to identify relevant factors in the pathogenesis of spastic cerebral palsy (CP) through protein profiling. Tissue-nonspecific alkaline phosphatase (TNAP) was found to be downregulated in spastic CP. The levels of TNAP were significantly lower in children with CP and model rats. In addition, the model rats showed an increase in osteopontin and proinflammatory biomarkers, as well as a decrease in serum 25 hydroxyvitamin D and IL-10. Serum TNAP level was positively correlated with serum CRP and IL-10 in model rats.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Eva Steidle-Kloc, Torben Dannhauer, Wolfgang Wirth, Felix Eckstein
Summary: This study explored the responsiveness of thigh subcutaneous and intermuscular fat, as well as muscle, during weight loss and gain, and found that MRI is a sensitive tool for monitoring changes in thigh adipose tissue composition.
CELLS TISSUES ORGANS
(2022)
Article
Food Science & Technology
Dongwoo Lee, Jaewon Kim, Ja-Young Oh, Mi-Hyang Han, Da-Ye Kim, Ji-Hye Kang, Dae-Hyun Jang
Summary: In children with spastic hemiplegic cerebral palsy, muscle mass of the affected leg decreases at 4 weeks after BoNT injection but significantly recovers by 12 weeks post-injection. The LBM of both legs and total limbs show a significant increase over the 12-week study period, indicating positive outcomes for rehabilitation.
Article
Clinical Neurology
Michael P. Trevarrow, Saihari S. Dukkipati, Sarah E. Baker, Tony W. Wilson, Max J. Kurz
Summary: This study used high-resolution structural MRI and biomechanical analyses to examine the changes in volume of the brainstem in individuals with cerebral palsy (CP) and its relationship with mobility impairments. The results showed a significant decrease in brainstem volume in individuals with CP, which were associated with reduced gait velocity and step length.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ivana Dzinovic, Matej Skorvanek, Petra Pavelekova, Chen Zhao, Boris Keren, Sandra Whalen, Somayeh Bakhtiari, Sheng Chih Jin, Michael C. Kruer, Robert Jech, Juliane Winkelmann, Michael Zech
Summary: Research has found a possible link between variant FBXO31 gene and a neurodevelopmental disorder characterized by prominent motor dysfunction.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Article
Neurosciences
Sujiao Li, Xueqin Luo, Song Zhang, Yuanmin Tang, Jiming Sun, Qingyun Meng, Hongliu Yu, Chengyan Sun
Summary: The study investigated changes in muscle force and tension after multilevel surgical treatments in children with spastic cerebral palsy, as well as evaluated the clinical effects of the surgeries on neuromuscular function during walking. Results showed significant improvements in muscle activation state and electromyography signals post-surgery, indicating the feasibility and effectiveness of the treatments.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Rehabilitation
Claire Willis, Catherine Elliott, Siobhan Reid, Astrid Nyquist, Reidun Jahnsen, Sven Bolte, Michael Rosenberg, Sonya Girdler
Summary: This study identified 14 active ingredients of a participation-focused physical activity intervention for children and youth with disabilities, categorized at the level of the intervention, the organization, and the individual. The findings highlighted the importance of the environment, particularly support and relationships, for enabling physical activity participation among this population.
DISABILITY AND REHABILITATION
(2022)
Article
Rehabilitation
Olav Amundsen, Cobie Starcevich, Even Johansen Frisell, Tom Nordal, Sian Williams, Tim Mitchell, Darren Beales
Summary: The study introduced a visual imagery intervention called Body Scan for individuals post ACL-reconstruction, with majority of participants able to perform it and showing improvements in perception and functional measures. It suggests that this intervention could be a beneficial adjunct to rehabilitation post surgery, warranting further research.
PHYSIOTHERAPY THEORY AND PRACTICE
(2022)
Article
Anatomy & Morphology
Sian A. Williams, Matthew Bell, Hyun K. Kim, Ghaliya Salim Al Masruri, N. Susan Stott, Justin Fernandez, S. Ali Mirjalili
Summary: This study confirmed the reliability of using freehand 3D ultrasound to measure triceps surae muscle volume in typically developing infants, with acceptable levels of agreement compared to MRI. Despite overestimating the volume of the medial and lateral gastrocnemius muscles, and underestimating the soleus muscle, freehand 3D ultrasound is still a useful tool for assessing changes in muscle volume in infants.
JOURNAL OF ANATOMY
(2022)
Review
Anatomy & Morphology
Matthew Bell, Ghaliya Al Masruri, Justin Fernandez, Sian A. Williams, Anne M. Agur, Ngaire S. Stott, Behzad Hajarizadeh, Ali Mirjalili
Summary: This review examined the imaging modalities and reliability analyses used to assess the morphological and architectural properties of the m. triceps surae muscle in typically developing children. The results showed an increase in muscle volume and physiological cross-sectional area with age, but no clear trend was observed with fibre bundle length or pennation angle. Limitations in correlating muscle variables with age were attributed to a lack of longitudinal data and methodological variations between studies.
JOURNAL OF ANATOMY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
K. Fortnum, S. Reid, C. Elliott, B. Furzer, J. Wong, B. Jackson
Summary: The study revealed that children with mental health disorders primarily engage in play-based, unstructured physical activities with their families. Social connection (or disconnection), children's movement skill and resilience, and a desire for success and enjoyment were identified as key influencers of children's physical activity participation experiences.
QUALITATIVE RESEARCH IN SPORT EXERCISE AND HEALTH
(2022)
Review
Orthopedics
Geoffrey G. Handsfield, Sian Williams, Stephanie Khuu, Glen Lichtwark, N. Susan Stott
Summary: Cerebral palsy (CP) is a disease caused by static brain damage during pregnancy or the first two years of life, which results in musculoskeletal impairments and movement disorders. The disease manifests differently in individuals, with muscles in CP showing deviations in volume, length, and sarcomere distribution compared to typical muscles. This may lead to reduced physical activity and a vicious cycle of muscle disuse and secondary sarcopenia.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Multidisciplinary Sciences
Salim G. Bin Ghouth, Sian A. Williams, Siobhan L. Reid, Thor F. Besier, Geoffrey G. Handsfield
Summary: This study investigated the morphological characteristics of the soleus muscle in children with cerebral palsy (CP) and typically developing children, and identified distinct features between the two groups using statistical shape modeling. The study found that children with CP had smaller and longer soleus muscles compared to typically developing children. These findings suggest impaired muscle function in children with CP.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Maxine M. Fong, Noula Gibson, Sian A. Williams, Lynn Jensen
Summary: This study aimed to identify the most frequently reported non-instrumented measures of gait, activity, and participation in children with cerebral palsy (CP) after undergoing gait corrective orthopaedic surgery. The results showed that 14 different outcome measures were used, with the Edinburgh Visual Gait Scale (EVGS) being the most common measure for gait, the Functional Mobility Scale (FMS) for activity, and the Pediatric Outcomes Data Collection Instrument for participation.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Dora Batia Dyne Steel, Federica Rachele Danti, Mohamed Abunada, Benjamin Kamien, Sony Malhotra, Maya Topf, Marios Kaliakatsos, Jane Valentine, Andrea Hilary Nemeth, Sandeep Jayawant, Kimberley M. Reid, Kshitij Mankad, Sniya Sudhakar, Hilla Ben-Pazi, Katy Barwick, Manju A. Kurian
Summary: Birk-Landau-Perez syndrome is a genetic disorder caused by biallelic pathogenic variants in SLC30A9, presenting with a complex movement disorder, developmental regression, oculomotor abnormalities, and renal impairment. This study describes the clinical phenotype of 8 individuals from 4 unrelated families with SLC30A9-related disease. The findings expand the known phenotype of this syndrome.
Article
Medicine, General & Internal
Catherine Morgan, Nadia Badawi, Roslyn N. Boyd, Alicia J. Spittle, Russell C. Dale, Adrienne Kirby, Rod W. Hunt, Koa Whittingham, Kerstin Pannek, Rachael L. Morton, William Tarnow-Mordi, Michael C. Fahey, Karen Walker, Kristina Prelog, Catherine Elliott, Jane Valentine, Andrea Guzzetta, Shannon Olivey, GAME Study Team, Iona Novak
Summary: This is a randomized controlled trial on early intervention for cerebral palsy (CP) children. The trial aims to investigate the efficacy of an early and sustained Goals-Activity-Motor Enrichment approach on improving motor and cognitive skills in infants with suspected or confirmed CP. The study requires 150 participants per group and the outcomes will be disseminated through peer-reviewed journal publications, international conferences, and consumer websites.
Article
Medicine, General & Internal
Leanne Sakzewski, Dayna Pool, Ellen Armstrong, Sarah Elizabeth Reedman, Roslyn N. Boyd, Catherine Elliott, Iona Novak, Stewart Trost, Robert S. Ware, Tracy Comans, Rachel Toovey, Mark D. Peterson, Megan Kentish, Sean Horan, Jane Valentine, Sian Williams
Summary: This study aims to compare the effectiveness of Active Strides-CP and usual care in children with bilateral cerebral palsy. The study includes 150 children, divided into two groups, and will conduct an 8-week intervention and compare it with usual care. The primary outcome measure is GMFM-66.
Article
Pediatrics
Rowan W. Johnson, Becky K. White, Noula Gibson, Daniel F. Gucciardi, Sian A. Williams
Summary: This study evaluated the feasibility of using the Zingo app for delivering school and home therapy programs for children with neurodisability. The results showed that most participants had good program adherence and engagement, and the app quality was highly rated by users. The findings support the use of the Zingo app as a motivator for therapy completion in children.
PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
(2023)
Article
Computer Science, Information Systems
Romero Morais, Vuong Le, Catherine Morgan, Alicia Spittle, Nadia Badawi, Jane Valentine, Elizabeth M. Hurrion, Paul A. Dawson, Truyen Tran, Svetha Venkatesh
Summary: FidgetyFind is a method that detects and assesses the quality of general movements in infants. It is highly interpretable and accurate, utilizing measurements of movement variability in short video segments. The method translates these measurements into a single score, similar to the process used by domain experts. Evaluation on a large clinical dataset demonstrated the superior interpretability and accuracy of FidgetyFind compared to other published methods.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Public, Environmental & Occupational Health
Karen Wright, Aria Dehar, N. Susan Stott, Anna Mackey, Alexandra Sorhage, Rachel Tapera, Sian A. Williams
Summary: This study found that many health registers do not prioritize Indigenous health inequities, and there are few strategies specific to Indigenous peoples for data ascertainment and quality. Health registers have the opportunity to be accountable, implement approaches to support Indigenous health equity, address structural determinants of inequities, and achieve health gains for all.
GLOBAL HEALTH RESEARCH AND POLICY
(2022)
