Article
Immunology
Laura Moreno de Lara, Alexandra Werner, Anna Borchers, Francisco J. Carrillo-Salinas, Wendelin Marmol, Siddharth Parthasarathy, Vidya Iyer, Alison Vogell, Diego Illanes, Ana C. Abadia-Molina, Christina Ochsenbauer, Charles R. Wira, Marta Rodriguez-Garcia
Summary: There is an increasing risk of HIV acquisition through sexual transmission in women over the age of 50. This study investigates the mechanisms behind the release of neutrophil extracellular traps (NETs), which provide innate protection against HIV infection, in the female genital tract (FGT). The findings show that the triggers for NET release differ between blood and genital tissues, and that aging affects the release of NETs. These results have important implications for understanding HIV protection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lianghan Zhu, Zhaoting Li, Ning Liu, Honghao Sun, Yixin Wang, Minjie Sun
Summary: The study explores a protein delivery strategy using poly amino acid conjugated with polyethylene glycol (PAAP) to prevent liver metastasis by degrading chromatin and disassembling NET-DNA. This approach not only suppresses tumor growth by degrading intracellular chromatin, but also prevents liver metastasis by disassembling NET-NDA, providing potential new inspiration for patients with metastatic colon and breast cancer.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Editorial Material
Oncology
Phei Er Saw, Jianing Chen, Erwei Song
Summary: Neutrophil extracellular traps (NETs) are involved in both infection control and tumor metastasis. The study by Mousset et al. published in Cancer Cell reveals that chemotherapy-induced inflammation promotes NETosis in malignant tumors, leading to chemoresistance. This finding highlights the potential of targeting inflammatory NETs for cancer treatment.
Review
Immunology
Hua Zhong, Ren-Yi Lu, Yan Wang
Summary: Fungal infections present a growing challenge in healthcare. Neutrophils are essential in defense against fungal infections and employ various mechanisms like phagocytosis, oxidative bursts, and the formation of extracellular traps to eliminate fungal invaders. The study of neutrophil extracellular traps (NETs) has made significant progress since its discovery, and this article describes the formation, induction, and function of NETs, as well as fungal strategies to evade NETs hunting.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Marina Stoimenou, Georgios Tzoros, Panagiotis Skendros, Akrivi Chrysanthopoulou
Summary: Several studies suggest that NETs may play a role in inflammatory and thrombotic disorders, thus serving as potential therapeutic or diagnostic tools. This article compares commonly used techniques for assessing NET formation and discusses the challenges and advantages in evaluating NETs. The review provides insights into the molecular analysis of NETs in translational medicine today.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Barbara M. Schultz, Orlando A. Acevedo, Alexis M. Kalergis, Susan M. Bueno
Summary: This review summarizes the role of NETs during bacterial and viral infections, explaining the molecular mechanisms involved in their formation and their relationship with different components of such pathogens.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hannes A. Baukmann, Justin L. Cope, Colin Bannard, Alexander R. E. C. Schwinges, Margaretha R. J. Lamparter, Sarah Groves, Charles N. J. Ravarani, Borko Amulic, Joern E. Klinger, Marco F. Schmidt
Summary: Despite the availability of vaccines to prevent SARS-CoV-2 infection, treating critically ill COVID-19 patients remains crucial. This study presents an alternative method for identifying drug repurposing targets by screening disease-causing traits, leading to the discovery of potential treatment targets for critical illness.
Article
Biochemistry & Molecular Biology
Caren Linnemann, Andreas K. Nussler, Tina Histing, Sabrina Ehnert
Summary: This study found that NETs severely impaired the viability and migration of SCP-1 cells, and had a persistent negative effect on osteogenic differentiation. The addition of DNase or protease inhibitors failed to reverse the negative effect of NETs, while a short febrile-range temperature treatment successfully reduced the toxicity and membrane destruction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Y. Cai, J. Liang, X. Chen, G. Zhang, Z. Jing, R. Zhang, L. Lv, W. Zhang, X. Dang
Summary: This study aimed to explore the diagnostic value of synovial fluid neutrophil extracellular traps (SF-NETs) in periprosthetic joint infection (PJI) diagnosis, and compare it with other diagnostic methods. The results showed that SF-NET can significantly improve the accuracy of PJI diagnosis. SF-NET is a novel and ideal synovial fluid biomarker for PJI diagnosis.
BONE & JOINT RESEARCH
(2023)
Editorial Material
Medicine, Research & Experimental
Erin B. Taylor
Summary: This article discusses the importance of dysregulation of neutrophil extracellular trap formation in viral infections and explores treatment methods targeting NET formation.
Article
Fisheries
Jingjing Zhao, Weijie Chen, Yuanxing Zhang, Qin Liu, Dahai Yang, Zhuang Wang
Summary: This study reveals the important role of pyroptosis in the formation of NETs in turbot neutrophils, suggesting that NETs formation is a critical immune response during bacterial infection in teleost fish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kritsanawan Sae-khow, Awirut Charoensappakit, Direkrit Chiewchengchol, Asada Leelahavanichkul
Summary: Vitamin C plays an important role in neutrophil function and has been studied in the treatment of sepsis. High-dose intravenous vitamin C (HDIVC) has been shown to improve neutrophil activity and microbial control, but long-term administration may have negative effects. Further studies are needed to determine the proper use of vitamin C in sepsis treatment.
Article
Critical Care Medicine
Scott H. Twaddell, Peter G. Gibson, Christopher Grainge, Katherine J. Baines
Summary: The study revealed that the concentrations of NET markers were significantly higher in parapneumonic effusions compared to effusions of other origins, indicating an association with inflammation. These findings may have implications for the treatment of parapneumonic effusions.
Article
Biochemical Research Methods
Xi-Rui Zhou, Ye Liu, Zhentao Huang, Qingxin Yao, Fangfei He, Yuan Gao
Summary: A redox supramolecular assembly (ROSA) system targeting HIV Gag protein was designed to trap HIV and control the virus, providing a potential anti-HIV strategy.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Christine Wrenzycki
Summary: This review article focuses on the interaction between neutrophils and sperm cells in cattle, with a special emphasis on the formation of neutrophil extracellular traps (NETs).
ANIMAL REPRODUCTION SCIENCE
(2022)