Review
Biochemistry & Molecular Biology
Yong-Kang Wang, Si-Yi Hu, Feng-Yi Xiao, Zhan-Bo Dong, Jian-Hui Ye, Xin-Qiang Zheng, Yue-Rong Liang, Jian-Liang Lu
Summary: Sweet tea, a popular herbal drink in southwest China, is rich in dihydrochalcones, which are mainly found in tender leaves of certain plants and have significant neuroprotective effects by regulating multiple pathological processes.
Article
Biochemistry & Molecular Biology
Feng-Xiang Zhang, Yu-Lin-Lan Yuan, Shuang-Shuang Cui, Min Li, Xuan Tan, Zuo-Cheng Qiu, Rui-Man Li
Summary: Food additives have gained extensive attention worldwide due to their side-effects. This study utilized a combination of metabolite profiling and network pharmacology to characterize the metabolic features of neohesperidin dihydrochalcone (NHDC) and reveal its pharmacological changes. The results showed that NHDC undergoes hydrolysis and conjugation reactions in vivo, with its metabolites involved in various pathways, suggesting potential novel functions or side-effects.
Article
Medicine, Research & Experimental
Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici
Summary: The study demonstrated that Phloretin (PH) and Phloridzin (PZ) had protective effects against cisplatin-induced nephrotoxicity by regulating oxidative stress and inflammatory response, improving renal function enzyme levels. Additionally, PH and PZ normalized SOD and GSH levels, suppressed MDA levels, reduced the expressions of inflammatory factors and nuclear factors, and decreased HSP70 expression.
Article
Biochemistry & Molecular Biology
Ngoc Anh Nguyen, Ngoc Tan Cao, Thi Huong Ha Nguyen, Jung-Hwan Ji, Gun Su Cha, Hyung-Sik Kang, Chul-Ho Yun
Summary: Phlorizin, a glucoside found in apple trees, can be hydroxylated to produce a potentially valuable product, 3-OH phlorizin, with help from Bacillus megaterium CYP102A1. This hydroxylated product shows potential for treating obesity and hyperglycemia, making it a promising candidate for future medical applications.
Article
Multidisciplinary Sciences
Shalini Dixit, Shiv Vardan Singh, Shilpa Mohanty, Dnyaneshwar U. Bawankule, Anirban Pal, Karuna Shanker, M. M. Gupta, Tahmeena Khan, Nora Abdullah AlFaris, Jozaa Zaidan Altamimi, Tahany Saleh Aldayel
Summary: This study evaluated the neuroprotective, antioxidant, and antiplasmodial properties of polyphenols from Malus Sikkimensis. The results showed that phloretin displayed better antioxidant potential and significant antiplasmodial activity. Phloridzin and phloretin suppressed the release of pro-inflammatory cytokines in a dose-dependent manner and had potential anti-neuroinflammatory effects.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Review
Food Science & Technology
Ruoqi Wang, Wenwen You, Heng Lin, Yunlin Cao, Changjie Xu, Kunsong Chen, Yilong Liu, Xian Li
Summary: This review explores the health-promoting activities of bitter substances and the taste conversions between bitter and sweet compounds. Naringin and neohesperidin can be transformed from bitter to intensely sweet through hydrogenation, potentially serving as sweeteners without increasing sugar intake and calorie consumption.
FOOD QUALITY AND SAFETY
(2023)
Article
Pharmacology & Pharmacy
Yuka Takahashi, Katsuya Narumi, Takanobu Nadai, Hinata Ueda, Taiki Yamamura, Ayako Furugen, Masaki Kobayashi
Summary: Apple polyphenols such as phloretin and phloridzin inhibit the transport of substrate drugs mediated by OATP2B1 in vitro. Specifically, phloretin can decrease the uptake of rosuvastatin in rats, suggesting a potential role in altering drug absorption. However, the systemic exposure of rosuvastatin was not significantly affected by phloretin in rats.
Article
Chemistry, Applied
Liang Zhang, Junhui Xu, Jing Qian, Yazhen Wang
Summary: ZIF-8/electrochemical reduced graphene oxide (ErGO) composite materials were successfully constructed on the glassy carbon electrode (GCE) without any dispersant in two simple steps, enabling the electrochemical sensing of Neohesperidin dihydrochalcone (NHDC). The morphology and structure of the composite materials were characterized using SEM and Raman. The detection of NHDC was achieved with a linear relationship between oxidation peak current and concentration, and a detection limit of 31.5 nM.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Seong Cheol Kim, Hyeon Jeong Kim, Gi Eun Park, Ramesh Prasad Pandey, Jisun Lee, Jae Kyung Sohng, Yong Il Park
Summary: This study demonstrated that Tri inhibits osteoclastic cell differentiation and bone resorption by down-regulating the expression of osteoclastogenic marker genes and signalling proteins, bone resorptive proteins, and by augmenting serum OPG/RANKL ratio, suggesting that Tri can be a novel anti-osteoporotic compound for treating senile and postmenopausal OP.
Article
Nutrition & Dietetics
Minseo Kwon, Yerin Kim, Jihye Lee, John A. Manthey, Yang Kim, Yuri Kim
Summary: Neohesperidin dihydrochalcone (NHDC) and its derivative NHDC-O-glycoside (GNHDC) can inhibit obesity and lipid accumulation through regulating multiple pathways.
Article
Biochemistry & Molecular Biology
Tomoya Nakagita, Takumi Matsuya, Masataka Narukawa, Takuya Kobayashi, Takatsugu Hirokawa, Takumi Misaka
Summary: This study created a docked model of the transmembrane domain (TMD) of the T1R3 subunit of the human sweet taste receptor with neohesperidin dihydrochalcone (NHDC) and identified important residues for NHDC recognition. The docking mode of NHDC with T1R3 TMD was distinct from that of lactisole, a sweet taste inhibitor.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
A. N. Zhu, K. Y. Zhang, J. P. Wang, S. P. Bai, Q. F. Zeng, H. W. Peng, X. M. Ding
Summary: NHDC, a class of natural flavonoids, has gained attention in nutrition research. This study demonstrates that dietary NHDC can improve egg production and quality for laying hens, as well as affect serum biochemistry and intestinal morphology.
Article
Nutrition & Dietetics
Si-Yuan Chen, Qing Yi-Jun Zhou, Lin Chen, Xin Liao, Ran Li, Tao Xie
Summary: Inflammatory bowel disease (IBD) is a chronic, relapsing immune-mediated disease that leads to progressive loss of intestinal function. This study found that Aurantii Fructus immaturus flavonoid extract (AFI) has a significant protective effect against DSS-induced intestinal inflammation and regulates the gut microbiome.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Paula Sol Pok, Victor Alonso Garcia Londono, Sebastian Vicente, Ana Pacin, Stella Maris Alzamora, Silvia Liliana Resnik
Summary: The use of flavonoids from citrus industry residues can effectively reduce the accumulation of fumonisins in maize and cause destructive effects on the cell structure of Fusarium, offering a potential natural and environmentally friendly antifungal treatment for stored maize.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Food Science & Technology
Qili Zhang, Li Wang, Yanfang Zhao
Summary: Lithocarpus polystachyus is a versatile pharmacological agent with a wide range of activities, including antioxidation, anti-inflammation, anti-diabetes, anti-tumor, anti-hypertension, anti-obesity, hepatoprotection, and neuroprotection. Its major active ingredients, dihydrochalcones, have various biological properties. This review summarizes the latest research on L. polystachyus, providing a scientific basis for understanding its health benefits and potential novel applications.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ban Chen, Xican Li, Xiaojian Ouyang, Jie Liu, Yangping Liu, Dongfeng Chen
Summary: Ferrostatin-1 mainly inhibits ferroptosis by electron transfer of aromatic N-atoms, while piceatannol and astringin preferentially inhibit ferroptosis through hydrogen donation at the 4'-OH position, ultimately forming dimers.
Article
Chemistry, Multidisciplinary
Ban Chen, Xican Li, Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Dongfeng Chen
Summary: The search for safe and effective ferroptosis inhibitors is a crucial topic, and geraniin, a compound containing HHDP and DHHDP groups, has shown potential in inhibiting ferroptosis in bmMSCs by demonstrating strong lipid peroxidation inhibition, Fe2+ chelating, and antioxidant actions. Geraniin does not form radical adducts due to its bulky HHDP (or DHHDP) group, making it a safe and effective ferroptosis inhibitor.
Article
Chemistry, Multidisciplinary
Yangping Liu, Xican Li, Yujie Hua, Wenhui Zhang, Xianxi Zhou, Jianfeng He, Dongfeng Chen
Summary: This study comparatively evaluated the ferroptosis-inhibitory activities of tannic acid and beta-PGG, revealing that tannic acid could inhibit ferroptosis in bmMSCs through radical trapping and ferrous complexation pathways. The 3'-O-galloylation reaction of tannic acid enhanced its radical trapping and indirect radical trapping to enhance ferroptosis inhibition.
Article
Medicine, Research & Experimental
Sen Ye, Jun Zhong, Jiapei Huang, Lichun Chen, Lan Yi, Xican Li, Jianping Lv, Jifei Miao, Hui Li, Dongfeng Chen, Caixia Li
Summary: The study demonstrated that Plastrum testudinis extract (PTE) and its active ingredient ethyl stearate can upregulate tyrosine hydroxylase (TH) expression in dopaminergic neurons, while reducing alpha-synuclein levels to protect against Parkinson's disease. The mechanisms may involve increasing methylation levels of the Snca intron 1 region, potentially disrupting abnormal aggregation of DNA methyltransferase 1 (DNMT1) with alpha-synuclein and ultimately decreasing alpha-synuclein expression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lin Yang, Yangping Liu, Wenhui Zhang, Yujie Hua, Ban Chen, Quanzhou Wu, Dongfeng Chen, Shuqin Liu, Xican Li
Summary: The study found that hydrolyzable tannins, namely chebulagic acid and chebulinic acid, can serve as natural ferroptosis inhibitors. Their ferroptosis inhibition is mediated through conventional antioxidant pathways (ROS scavenging and iron chelation) instead of the redox-based catalytic recycling pathway exhibited by Fer-1. The HHDP moiety in chebulagic acid enables ferroptosis-inhibitory action of hydrolyzable tannins through antioxidant pathways.
Article
Chemistry, Multidisciplinary
Yujie Hua, Xican Li, Wenhui Zhang, Ban Chen, Yamei Liu, Xiaojun Zhao, Hong Xie, Dongfeng Chen
Summary: Folium Hibisci Mutabilis contains eight antioxidant flavonoids, with tiliroside and vitexin showing higher antioxidant activity. These flavonoids can produce coupling products during the antioxidant process. Specifically, tiliroside forms a coupling product using para-coumaroyl as a linker.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Shuqin Liu, Xican Li, Ban Chen, Xiaojian Ouyang, Yulu Xie, Dongfeng Chen
Summary: Phytophenol dimerization is a crucial coupling reaction in lignin biosynthesis and other fields. The products and structure-function relationship of this reaction have been investigated, revealing four basic rules and explaining the diastereoselectivity and the role of catalysts.
Article
Agriculture, Multidisciplinary
Xican Li, Xiaojian Ouyang, Ban Chen, Shuqin Liu, Jingyuan Zeng
Summary: The present study developed a smart and novel strategy to elucidate the linkage and stereochemistry characters during phenolic antioxidant product formation. A series of phenolic isomers or analogues were treated with 2-phenyl-4,4,5,5tetramethylimidazoline-1-oxyl-3-oxide radical, resulting in 16 antioxidant dimerization reactions in aqueous solution. The products were rapidly identified using ultraperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass-spectrometry. Through a systematic function-structure relationship analysis of these reactions and theoretical calculations, it was concluded that the phenolic antioxidant product is formed via linear linkage or furanocyclic linkage. The furanocyclic linkage is characterized by a,fi diastereoselectivity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Physical
Xican Li, Shuqin Liu, Jingyuan Zeng, Rongxing Cai, Chunhou Li, Ban Chen, Dongfeng Chen
Summary: This study explored the substrate specificity and diastereoselective process of laccase from Trametes versicolor (Lac TV) in transforming phytophenol into furanocyclic dimers. Through analysis, it was found that phytophenol furanocyclic dimerization requires a specific substrate structure with a C=C bond at the para position of -OH and conjugation with the phenolic core. The coumaran and 3,7-dioxabicyclo[3.3.0]octane linkage dimers exhibited distinct diastereoselective characteristics. These findings provide insights into the efficient utilization of Lac TV in phytophenol biosynthesis in chemistry fields.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen
Summary: A novel C6-sulfonated celastrol analog (CENFN) was designed and synthesized, and its tyrosinase and melanin inhibitory effects were compared to celastrol (CE) using in silico and in vitro experiments. The results confirmed the rationality of the synthetic reactions and showed that CENFN has a higher level of tyrosinase and melanin inhibition compared to CE. These findings provide insights for the design and synthesis of celastrol analogs as tyrosinase and melanin inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Ban Chen, Jiangtao Su, Yuchen Hu, Shuqin Liu, Xiaojian Ouyang, Rongxin Cai, Xiangyu You, Xican Li
Summary: This study compared the antioxidant processes of four different structural types of 4',5,7-trihydroxyflavonoids. The results showed that the structural type can affect the antioxidant ability, site, and speed. After hydrogen abstraction at C-4'-OH, different types of compounds will produce antioxidant products via C-3'-radical linking.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenhui Zhang, Xican Li, Yujie Hua, Zhen Li, Ban Chen, Aijun Liu, Wenbiao Lu, Xiaojun Zhao, Yuanming Diao, Dongfeng Chen
Summary: This study identified eight antioxidant phytophenols in Hulu Tea, which can generate three types of antioxidant products through interactions with cellular reactive oxygen species.
NEW JOURNAL OF CHEMISTRY
(2021)