Article
Pharmacology & Pharmacy
Catarina Alves de Lima Serafim, Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Junior, Leiliane Macena Oliveira Silva, Alessa Oliveira Silva, Marcelo Sobral da Silva, Adriano Francisco Alves, Aurigena Antunes Araujo, Leonia Maria Batista
Summary: (-)-Carveol exhibits low toxicity and significant antiulcer activity in animal models, likely through mechanisms involving antisecretory, cytoprotective, antioxidant, and immunomodulatory effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
Kun-Lai Sun, Min Gao, Yue-Zhen Wang, Xue-Rong Li, Peng Wang, Bin Wang
Summary: This study extracted two proteins from red algae and obtained six antioxidant peptides through hydrolysis. Among them, EP4 and EP5 showed strong antioxidant activity and potential for treating chronic cardiovascular diseases.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wadie E. F. Bahou, Natalia Marchenko, Natasha M. M. Nesbitt
Summary: Cytoprotective heme oxygenases convert heme into carbon monoxide, ferrous iron, and biliverdin, which is rapidly reduced to bilirubin by biliverdin IX beta reductase (BLVRB). Recent studies have found that BLVRB plays a role in regulating the fate of hematopoietic stem cells, specifically in megakaryocyte and erythroid development. Crystallographic and thermodynamic studies have provided valuable insights into the biochemistry and genetics of BLVRB, paving the way for the development of selective inhibitors with potential therapeutic applications in hematopoietic and other disorders.
Article
Biochemistry & Molecular Biology
Agnieszka Irena Mazur-Bialy, Ewa Pochec
Summary: This study found that irisin effectively reduced free radical production by macrophages and altered the kinetics of key factors in the Nrf2/HO-1/HMGB1 pathway, leading to increased production of Nrf2 and HO-1 while significantly reducing HMGB1 release.
Article
Agriculture, Multidisciplinary
Liujing Li, Hanbin Xu, Jiaping Zhou, Jinglin Yu, Les Copeland, Shujun Wang
Summary: Black tea extract showed the strongest inhibition on in vitro enzymatic starch digestion and alpha-amylase activity among four types of tea extracts. Theaflavins in black tea were found to bind more strongly to alpha-amylase and have a greater inhibitory effect compared to catechins. The higher content of theaflavins in black tea extract contributed to its stronger inhibitory effect on alpha-amylase.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Zeyu Wang, Jinbao Huang, Dawei Yun, Huimin Yong, Jun Liu
Summary: Four catechins were conjugated onto chitosan to develop antioxidant food packaging films. The catechins improved the antioxidant activity of chitosan, with EGCG-g-CS being the most effective. The developed films showed enhanced thickness, strength, thermal stability, and antioxidant activity compared to chitosan films.
FOOD HYDROCOLLOIDS
(2022)
Article
Biochemistry & Molecular Biology
Federico Manai, Marialaura Amadio
Summary: Dimethyl fumarate activates the Nrf2 pathway in human retinal endothelial cells, leading to a decrease in oxidative stress and providing cytoprotective effects in a hyperglucose stress model.
Article
Engineering, Chemical
D. L. Meneses, Y. Ruiz, E. Hernandez, F. L. Moreno
Summary: The study demonstrated that block freeze-concentration is an effective technique for increasing catechin and polyphenol content in green tea, while preserving antioxidant activity and maintaining physicochemical parameters and sensory attributes.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Theng Choon Ooi, Farah Wahida Ibrahim, Shakirah Ahmad, Kok Meng Chan, Lek Mun Leong, Nihayah Mohammad, Ee Ling Siew, Nor Fadilah Rajab
Summary: The aqueous extract of Ficus deltoidea var. deltoidea showed no mutagenic effect on Salmonella typhimurium strains, but exhibited antimutagenic and cytoprotective effects, likely due to its antioxidant properties.
Article
Biochemistry & Molecular Biology
Alby Tom, Jisha Jacob, Manoj Mathews, Rajakrishnan Rajagopal, Ahmed Alfarhan, Damia Barcelo, Arunaksharan Narayanankutty
Summary: Plant secondary metabolites, such as chalcones, are important sources of biologically active compounds with pharmacological potentials. Natural chalcones and bis-chalcones have shown high antioxidant and anti-inflammatory properties in various experiments. This study evaluated the effects of six synthetic bis-chalcones on intestinal epithelial cells and studied their anti-inflammatory potentials in macrophages. The results indicate that these synthetic bis-chalcones have cytoprotective and anti-inflammatory abilities.
Article
Agriculture, Multidisciplinary
Huimin Yong, Huixia Hu, Zhihao Wang, Dawei Yun, Juan Kan, Jun Liu
Summary: By using acid-mediated coupling method, catechins were successfully conjugated onto dialdehyde starch to form stable dialdehyde starch-catechin conjugates. The conjugates exhibited improved thermal stability and enhanced stability of catechins in buffered solution. Furthermore, the conjugates showed higher antioxidant activity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Huijin Heo, Hana Lee, Jinhee Park, Kyeong-Hoon Kim, Heon-Sang Jeong, Junsoo Lee
Summary: This study evaluated the antioxidant and cytoprotective capacities of 41 wheat cultivars and examined their correlation. The results showed variations in antioxidant and cytoprotective capacities among different wheat cultivars, providing basic information for decision-making in wheat breeding programs and the development of functional food crops.
Article
Biochemistry & Molecular Biology
Jayeeta Manna, Gary L. Dunbar, Panchanan Maiti
Summary: The study showed that a highly bioavailable curcuminoid formulation, Curcugreen, can reduce peripheral organ abnormalities and inflammatory responses in AD mouse models, as well as lower levels of amyloid deposition, proinflammatory markers, and cell death. This suggests that curcuminoids have a protective effect on AD.
Article
Food Science & Technology
Yaotong Liu, Yuanyuan Bian, Yan Bai, Siqi Yu, Yuxuan Tian, Jie Li, Suhong Li, Tuoping Li
Summary: Potato protease inhibitors (PPIs), derived from potato protein isolate, have excellent safety, nutritional value, and a promising market potential. Cell-based assays have shown that PPIs possess antioxidative and anticancer properties. PPIs at a concentration of 5 mg/mL demonstrated a peroxyl radical scavenging value of (2,119 +/- 204) mg VCE/100 g, and cellular antioxidant activity values of (45.83 +/- 3.5) (no PBS wash) and (33.25 +/- 4.4) mu mol QE/100 g (PBS wash). Pre-treatment with PPIs prevented oxidative damage, inhibited morphological changes, and exhibited selective anti-proliferative effects on GIST882 cells (IC50 = (10.53 +/- 3.87) mg/mL). PPIs also showcased potent inhibition of cancer cell growth, migration, and invasion. These findings support the potential usage of PPIs as functional foods for preventing oxidative damage and cancer.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Food Science & Technology
Luciana Azevedo, Daniel Granato, Vinicius Maltarollo, Jose E. Goncalves
Summary: Agrifood system technologies have facilitated the creation of innovative foods with improved nutritional profiles. This article provides an overview of the development of food models/prototypes using natural compounds as a source of inspiration, through the integration of various disciplines and food technologies. To create healthy foods, the combination of interrelated technologies from nutrition, chemical synthesis, pharmacology, and food technology with biological system analyses is proposed. Developing food molecules is a slow process that involves mandatory steps based on desired bioactive properties, which is hindered by the diversity of food matrices and the complexity of reconstituting their biosynthetic pathways. Overcoming these challenges should be a primary focus in food science, leading to more sustainable processes and health benefits.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ban Chen, Xican Li, Xiaojian Ouyang, Jie Liu, Yangping Liu, Dongfeng Chen
Summary: Ferrostatin-1 mainly inhibits ferroptosis by electron transfer of aromatic N-atoms, while piceatannol and astringin preferentially inhibit ferroptosis through hydrogen donation at the 4'-OH position, ultimately forming dimers.
Article
Chemistry, Multidisciplinary
Ban Chen, Xican Li, Jie Liu, Yuling Li, Wanjian Dai, Yingci Chen, Dongfeng Chen
Summary: The search for safe and effective ferroptosis inhibitors is a crucial topic, and geraniin, a compound containing HHDP and DHHDP groups, has shown potential in inhibiting ferroptosis in bmMSCs by demonstrating strong lipid peroxidation inhibition, Fe2+ chelating, and antioxidant actions. Geraniin does not form radical adducts due to its bulky HHDP (or DHHDP) group, making it a safe and effective ferroptosis inhibitor.
Article
Chemistry, Multidisciplinary
Yangping Liu, Xican Li, Yujie Hua, Wenhui Zhang, Xianxi Zhou, Jianfeng He, Dongfeng Chen
Summary: This study comparatively evaluated the ferroptosis-inhibitory activities of tannic acid and beta-PGG, revealing that tannic acid could inhibit ferroptosis in bmMSCs through radical trapping and ferrous complexation pathways. The 3'-O-galloylation reaction of tannic acid enhanced its radical trapping and indirect radical trapping to enhance ferroptosis inhibition.
Article
Medicine, Research & Experimental
Sen Ye, Jun Zhong, Jiapei Huang, Lichun Chen, Lan Yi, Xican Li, Jianping Lv, Jifei Miao, Hui Li, Dongfeng Chen, Caixia Li
Summary: The study demonstrated that Plastrum testudinis extract (PTE) and its active ingredient ethyl stearate can upregulate tyrosine hydroxylase (TH) expression in dopaminergic neurons, while reducing alpha-synuclein levels to protect against Parkinson's disease. The mechanisms may involve increasing methylation levels of the Snca intron 1 region, potentially disrupting abnormal aggregation of DNA methyltransferase 1 (DNMT1) with alpha-synuclein and ultimately decreasing alpha-synuclein expression.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lin Yang, Yangping Liu, Wenhui Zhang, Yujie Hua, Ban Chen, Quanzhou Wu, Dongfeng Chen, Shuqin Liu, Xican Li
Summary: The study found that hydrolyzable tannins, namely chebulagic acid and chebulinic acid, can serve as natural ferroptosis inhibitors. Their ferroptosis inhibition is mediated through conventional antioxidant pathways (ROS scavenging and iron chelation) instead of the redox-based catalytic recycling pathway exhibited by Fer-1. The HHDP moiety in chebulagic acid enables ferroptosis-inhibitory action of hydrolyzable tannins through antioxidant pathways.
Article
Chemistry, Multidisciplinary
Yujie Hua, Xican Li, Wenhui Zhang, Ban Chen, Yamei Liu, Xiaojun Zhao, Hong Xie, Dongfeng Chen
Summary: Folium Hibisci Mutabilis contains eight antioxidant flavonoids, with tiliroside and vitexin showing higher antioxidant activity. These flavonoids can produce coupling products during the antioxidant process. Specifically, tiliroside forms a coupling product using para-coumaroyl as a linker.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Shuqin Liu, Xican Li, Ban Chen, Xiaojian Ouyang, Yulu Xie, Dongfeng Chen
Summary: Phytophenol dimerization is a crucial coupling reaction in lignin biosynthesis and other fields. The products and structure-function relationship of this reaction have been investigated, revealing four basic rules and explaining the diastereoselectivity and the role of catalysts.
Article
Agriculture, Multidisciplinary
Xican Li, Xiaojian Ouyang, Ban Chen, Shuqin Liu, Jingyuan Zeng
Summary: The present study developed a smart and novel strategy to elucidate the linkage and stereochemistry characters during phenolic antioxidant product formation. A series of phenolic isomers or analogues were treated with 2-phenyl-4,4,5,5tetramethylimidazoline-1-oxyl-3-oxide radical, resulting in 16 antioxidant dimerization reactions in aqueous solution. The products were rapidly identified using ultraperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass-spectrometry. Through a systematic function-structure relationship analysis of these reactions and theoretical calculations, it was concluded that the phenolic antioxidant product is formed via linear linkage or furanocyclic linkage. The furanocyclic linkage is characterized by a,fi diastereoselectivity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Physical
Xican Li, Shuqin Liu, Jingyuan Zeng, Rongxing Cai, Chunhou Li, Ban Chen, Dongfeng Chen
Summary: This study explored the substrate specificity and diastereoselective process of laccase from Trametes versicolor (Lac TV) in transforming phytophenol into furanocyclic dimers. Through analysis, it was found that phytophenol furanocyclic dimerization requires a specific substrate structure with a C=C bond at the para position of -OH and conjugation with the phenolic core. The coumaran and 3,7-dioxabicyclo[3.3.0]octane linkage dimers exhibited distinct diastereoselective characteristics. These findings provide insights into the efficient utilization of Lac TV in phytophenol biosynthesis in chemistry fields.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Jiangtao Su, Dan Li, Yuchen Hu, Xiangyu You, Xiaoxia Guo, Xican Li, Ban Chen
Summary: A novel C6-sulfonated celastrol analog (CENFN) was designed and synthesized, and its tyrosinase and melanin inhibitory effects were compared to celastrol (CE) using in silico and in vitro experiments. The results confirmed the rationality of the synthetic reactions and showed that CENFN has a higher level of tyrosinase and melanin inhibition compared to CE. These findings provide insights for the design and synthesis of celastrol analogs as tyrosinase and melanin inhibitors.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Ban Chen, Jiangtao Su, Yuchen Hu, Shuqin Liu, Xiaojian Ouyang, Rongxin Cai, Xiangyu You, Xican Li
Summary: This study compared the antioxidant processes of four different structural types of 4',5,7-trihydroxyflavonoids. The results showed that the structural type can affect the antioxidant ability, site, and speed. After hydrogen abstraction at C-4'-OH, different types of compounds will produce antioxidant products via C-3'-radical linking.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Wenhui Zhang, Xican Li, Yujie Hua, Zhen Li, Ban Chen, Aijun Liu, Wenbiao Lu, Xiaojun Zhao, Yuanming Diao, Dongfeng Chen
Summary: This study identified eight antioxidant phytophenols in Hulu Tea, which can generate three types of antioxidant products through interactions with cellular reactive oxygen species.
NEW JOURNAL OF CHEMISTRY
(2021)