Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders

Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders

(2018) Patrick Schneider et al.   BEHAVIOURAL BRAIN RESEARCH

Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission

(2016) Petr Unichenko et al.   CEREBRAL CORTEX

Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways

(2016) Johannes Vogt et al.   CEREBRAL CORTEX

PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling

(2016) Xingfeng Liu et al.   DEVELOPMENTAL CELL

Lrp4 in astrocytes modulates glutamatergic transmission

(2016) Xiang-Dong Sun et al.   NATURE NEUROSCIENCE

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP

(2015) J. Vogt et al.   EMBO Molecular Medicine

Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression

(2015) Matthew G. K. Benesch et al.   FASEB JOURNAL

Lysophosphatidic Acid Signaling in the Nervous System

(2015) Yun C. Yung et al.   NEURON

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer

(2015) Efrosini Barbayianni et al.   PROGRESS IN LIPID RESEARCH

Spontaneous Gamma Activity in Schizophrenia

(2015) Yoji Hirano et al.   JAMA Psychiatry

Neural Oscillations and Synchrony in Brain Dysfunction and Neuropsychiatric Disorders

(2015) Daniel H. Mathalon et al.   JAMA Psychiatry

Interaction of platelet-derived autotaxin with tumor integrin  V 3 controls metastasis of breast cancer cells to bone

(2014) R. Leblanc et al.   BLOOD

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice

(2014) Matthew G. K. Benesch et al.   FASEB JOURNAL

LPA receptor signaling: pharmacology, physiology, and pathophysiology

(2014) Yun C. Yung et al.   JOURNAL OF LIPID RESEARCH

Autotaxin and LPA 1 and LPA 5 Receptors Exert Disparate Functions in Tumor Cells versus the Host Tissue Microenvironment in Melanoma Invasion and Metastasis

(2014) Sue-Chin Lee et al.   MOLECULAR CANCER RESEARCH

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics

(2014) Ute Distler et al.   PROTEOMICS

Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation

(2013) Gye Young Park et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Theta Oscillations in the Medial Prefrontal Cortex Are Modulated by Spatial Working Memory and Synchronize with the Hippocampus through Its Ventral Subregion

(2013) P.-K. O'Neill et al.   JOURNAL OF NEUROSCIENCE

Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia

(2013) Julia W.Y. Kam et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Imaging Patients with Psychosis and a Mouse Model Establishes a Spreading Pattern of Hippocampal Dysfunction and Implicates Glutamate as a Driver

(2013) Scott A. Schobel et al.   NEURON

A Metabolically-Stabilized Phosphonate Analog of Lysophosphatidic Acid Attenuates Collagen-Induced Arthritis

(2013) Ioanna Nikitopoulou et al.   PLoS One

Pulmonary Autotaxin Expression Contributes to the Pathogenesis of Pulmonary Fibrosis

(2012) Nikos Oikonomou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Abnormal bihemispheric responses in schizophrenia patients following cathodal transcranial direct stimulation

(2012) Alkomiet Hasan et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks

(2012) Peter J. Uhlhaas et al.   NEURON

Too Many Cooks? Intrinsic and Synaptic Homeostatic Mechanisms in Cortical Circuit Refinement

(2011) Gina Turrigiano   Annual Review of Neuroscience

Impaired long-term depression in schizophrenia: A cathodal tDCS pilot study

(2011) Alkomiet Hasan et al.   Brain Stimulation

Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting

(2011) Johannes Vogt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors

(2011) M. Lavialle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translating Glutamate: From Pathophysiology to Treatment

(2011) D. C. Javitt et al.   Science Translational Medicine

Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein

(2010) Jens Hausmann et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Abnormal neural oscillations and synchrony in schizophrenia

(2010) Peter J. Uhlhaas et al.   NATURE REVIEWS NEUROSCIENCE

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity

(2009) Ruggero Galici et al.   BEHAVIOURAL PHARMACOLOGY

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Synaptic PRG-1 Modulates Excitatory Transmission via Lipid Phosphate-Mediated Signaling

(2009) Thorsten Trimbuch et al.   CELL

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Neurophysiological biomarkers for drug development in schizophrenia

(2007) Daniel C. Javitt et al.   NATURE REVIEWS DRUG DISCOVERY