SLAB51 Probiotic Formulation Activates SIRT1 Pathway Promoting Antioxidant and Neuroprotective Effects in an AD Mouse Model

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

(2016) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ghrelin and Neurodegenerative Disorders—a Review

(2016) Limin Shi et al.   MOLECULAR NEUROBIOLOGY

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

(2016) Valeria D. Felice et al.   PARKINSONISM & RELATED DISORDERS

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Sirtuins Link Inflammation and Metabolism

(2016) Vidula T. Vachharajani et al.   Journal of Immunology Research

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

(2016) Carles Cantó et al.   Aging-US

Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the Sirt1 pathway

(2015) YU LOU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage

(2015) Liming Shen et al.   Journal of Proteomics

The role of leptin in the sporadic form of Alzheimer's disease. Interactions with the adipokines amylin, ghrelin and the pituitary hormone prolactin

(2015) Jaume Folch et al.   LIFE SCIENCES

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

(2015) Muriel Arimon et al.   NEUROBIOLOGY OF DISEASE

Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of AMP-activated protein kinase and sirtuin 1 activities

(2015) Zifeng Liu et al.   Journal of Diabetes

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Protective Effect of Leptin and Ghrelin against Toxicity Induced by Amyloid-β Oligomers in a Hypothalamic cell Line

(2014) S. Gomes et al.   JOURNAL OF NEUROENDOCRINOLOGY

Cilostazol suppresses β-amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1-coupled retinoic acid receptor-β

(2014) Hye Rin Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ghrelin: A link between ageing, metabolism and neurodegenerative disorders

(2014) I.I. Stoyanova   NEUROBIOLOGY OF DISEASE

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP

(2014) Eleonora Distrutti et al.   PLoS One

Amyloid-β and Tau

(2014) George S. Bloom   JAMA Neurology

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex

(2013) Yolanda Olmos et al.   ANTIOXIDANTS & REDOX SIGNALING

The role of microbiome in central nervous system disorders

(2013) Yan Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

(2013) Antero Salminen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Brain Activation of SIRT1: Role in Neuropathology

(2013) Alanna Fernandes Paraíso et al.   MOLECULAR NEUROBIOLOGY

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress

(2013) Yusuke S. Hori et al.   PLoS One

Alzheimer's disease and the microbiome

(2013) Surjyadipta Bhattacharjee et al.   Frontiers in Cellular Neuroscience

Ghrelin and leptin secretion in patients with moderate Alzheimer’s disease

(2012) Anastasia Theodoropoulou et al.   Journal of Nutrition Health & Aging

Elevation of glutathione as a therapeutic strategy in Alzheimer disease

(2011) Chava B. Pocernich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53

(2011) C. Zhang et al.   CARDIOVASCULAR RESEARCH

PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation

(2011) Péter Bai et al.   Cell Metabolism

Cellular and molecular effects of sirtuins in health and disease

(2011) Yoshiyuki Horio et al.   CLINICAL SCIENCE

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

Poly(ADP-ribose) Polymerase 1 (PARP-1) Binds to 8-Oxoguanine-DNA Glycosylase (OGG1)

(2011) Nicole Noren Hooten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis

(2009) Rukhsana Sultana et al.   ACTA NEUROPATHOLOGICA

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain

(2008) Changxing Shao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials

(2008) Armando P. Signore et al.   JOURNAL OF NEUROCHEMISTRY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY