Review
Biochemistry & Molecular Biology
Taobo Hu, Wei Hou, Enhua Xiao, Mengping Long
Summary: Stress granules are cytoplasmic foci induced by stress conditions, serving as a protective strategy to suppress overall translation. In cancer cells, stress granules formation can protect cells from apoptosis and contribute to resistance against anticancer drugs or radiation treatment. However, further research is needed to understand the clinical implications of stress granules.
Review
Oncology
Debmita Chatterjee, Oishee Chakrabarti
Summary: The interaction between senescence and SG formation plays a crucial role in tumorigenesis, potentially contributing to the development of gliomas and offering a new avenue for therapeutic intervention.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Jing Guo, Yangyang Lv, Sheng Wang, Ziyi Peng, Ying Xie, Yixuan Wang, Hongmei Jiang, Xin Li, Mengqi Wang, Meilin Hu, Jiangpeng Mu, Jingya Wang, Yangyang Xie, Xiankui Cheng, Zhigang Zhao, Zhiqiang Liu
Summary: The hypoxic bone marrow microenvironment in multiple myeloma (MM) promotes chemoresistance to proteasome inhibitors (PIs). The expression of steroid receptor coactivator 3 (SRC-3) is increased at the posttranslational level in response to hypoxia stimulus. SENP1, a key modifier of SRC-3 stability, is identified and its depletion or inhibition overcomes chemoresistance to PIs in MM cells.
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Chih-Cheng Wu, Jiaan-Der Wang, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: Elevation of intracellular cAMP levels through inhibition of phosphodiesterase using dipyridamole has shown to inhibit glioma cell proliferation, migration, and invasion. Dipyridamole induces apoptosis through Noxa-guided endoplasmic reticulum (ER) stress and impairs autophagic flux. YAP1 plays a role in the communication between ER stress and autophagy, promoting autophagy and protecting glioma cells from dipyridamole-induced apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Jeong In Lee, Sim Namkoong
Summary: Stress granules (SGs) are stress-induced subcellular compartments that protect cells from stress-related damage and death, and have an impact on cancer cell fitness and therapy.
Article
Cell Biology
Zhen Tang, Xinghui Wei, Tian Li, Wei Wang, Hao Wu, Hui Dong, Yichao Liu, Feilong Wei, Lei Shi, Xiaokang Li, Zheng Guo, Xin Xiao
Summary: The study elucidates the potential role of Sestrin2 in regulating the sensitivity of osteosarcoma to chemotherapy, demonstrating that Sestrin2 activates autophagy by inhibiting the mTOR pathway and decreases apoptosis via Bcl-2, ultimately slowing down tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Minkyeong Lee, Changwon Yang, Gwonhwa Song, Whasun Lim
Summary: Eupatilin, a natural product, inhibits growth and induces apoptosis in colon cancer cells. It affects oxidative stress, endoplasmic reticulum stress, autophagic process, and targets multiple signaling pathways, preventing cell invasion. Additionally, it synergizes with standard anticancer drugs to enhance their efficacy in colon cancer treatment.
Article
Food Science & Technology
Bogdan Jovanovic, Nina Eiermann, Deepti Talwar, Maria Boulougouri, Tobias P. Dick, Georg Stoecklin
Summary: Arsenic exerts its toxicity on cells through the inhibition of Trx1-induced SGs, which is crucial for cell survival in response to ASN exposure. The assembly of SGs plays a significant role in the toxic properties of ASN, highlighting the importance of Trx1 in cellular response to ASN exposure.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizadeh
Summary: This study developed a targeted delivery system based on nanostructured lipid carriers, which can effectively overcome the blood-brain barrier and blood-brain tumor barrier, and deliver therapeutics to glioma cells with high selectivity. It represents a promising treatment for brain cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Xiaohua Lu, Ge Yan, Sabine M. Klauck, Edmond Fleischer, Anette Klinger, Yoshikazu Sugimoto, Letian Shan, Thomas Efferth
Summary: MCC1734 demonstrates cytotoxicity towards multidrug-resistant cancer cell lines with different mechanisms, bypassing P-glycoprotein-mediated resistance. It affects cell function through various pathways, including cell cycle regulation, mitochondrial function, apoptosis signaling, and endoplasmic reticulum stress. The anti-cancer effects of MCC1734 are further supported by in vivo studies using human xenograft tumors transplanted to zebrafish.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Jonas S. Jutzi, Anna E. Marneth, Maria Jose Jimenez-Santos, Jessica Hem, Angel Guerra-Moreno, Benjamin Rolles, Shruti Bhatt, Samuel A. Myers, Steven A. Carr, Yuning Hong, Olga Pozdnyakova, Peter van Galen, Fatima Al-Shahrour, Anna S. Nam, Ann Mullally
Summary: This study identifies altered proteostasis in Calr-mutant MPN and proposes a strategy of combined targeting of proteasome and ER stress response to selectively treat Calr-mutated HSCs and megakaryocytic-lineage cells, resulting in amelioration of MPN phenotype.
Review
Biochemistry & Molecular Biology
Akanksha Verma, S. Sumi, Mahendra Seervi
Summary: Heat shock proteins (HSPs) play crucial roles in cell survival by interacting with apoptosis signaling components, maintaining protein homeostasis, and regulating the assembly and disassembly of stress granules (SGs) in the cytoplasm, which are important for cell survival under stressful conditions. Their intricate molecular signaling in and around the nexus of HSPs-SGs is essential in managing chronic diseases like cancer and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Cheng-Yi Chang, Ping-Ho Pan, Chih-Cheng Wu, Su-Lan Liao, Wen-Ying Chen, Yu-Hsiang Kuan, Wen-Yi Wang, Chun-Jung Chen
Summary: The study illustrates that gefitinib induces glioma cell apoptosis by activating ER stress and modulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Biochemistry & Molecular Biology
Dong Min Lee, Min Ji Seo, Hong Jae Lee, Hyo Joon Jin, Kyeong Sook Choi
Summary: Despite the success of proteasome inhibitors (PIs) in treating hematopoietic malignancies, their clinical efficacy is limited in solid tumors. This study investigated the involvement of the integrated stress response (ISR) in determining the fates of cells treated with the proteasome inhibitor, bortezomib (Bz). ISRIB, a small molecule that restores protein translation during ISR, reversed the ISR induced by Bz in both multiple myeloma (MM) cells and breast cancer cells, resulting in different outcomes: protecting MM cells from apoptosis and enhancing Bz sensitivity in breast cancer cells through inducing paraptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Mauricio R. Galiano, Victor E. Goitea, Marta E. Hallak
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Rodrigo O. de Castro, Luciana Previato, Victor Goitea, Anna Felberg, Michel F. Guiraldelli, Adrian Filiberti, Roberto J. Pezza
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biophysics
Cecilia Vasti, Laura V. Bonnet, Mauricio R. Galiano, Ricardo Rojas, Carla E. Giacomelli
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Neurosciences
Keiichiro Susuki, Daniel R. Zollinger, Kae-Jiun Chang, Chuansheng Zhang, Claire Yu-Mei Huang, Chang-Ru Tsai, Mauricio R. Galiano, Yanhong Liu, Savannah D. Benusa, Leonid M. Yermakov, Ryan B. Griggs, Jeffrey L. Dupree, Matthew N. Rasband
JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Jesica Belen Flores-Martin, Laura Vanesa Bonnet, Anabela Palandri, Sofia Zamanillo-Hermida, Marta Elena Hallak, Mauricio Raul Galiano
Summary: In this study, we investigated the effect of cold stress on the ubiquitin-proteasome system (UPS) in glial cells. We found that cold exposure led to a partial disassembly of the 26S proteasome, as well as a decrease in 20S proteolytic activity and an increase in polyubiquitinated proteins. We also observed the relocation of the Rpt5 subunit of the 19S proteasome to cold-stable microtubules, which was influenced by the expression of the microtubule-associated protein MAP6 and the post-translational acetylation of alpha-tubulin. This reversible association may play a role in maintaining the functionality of the proteolytic complex during cold stress.
Article
Neurosciences
Anabela Palandri, Laura Vanesa Bonnet, Maria Gimena Farias, Marta Elena Hallak, Mauricio Raul Galiano
Summary: Arginine addition can cause structural and functional changes in protein substrates mediated by Ate1. Ate1 plays a role in OL differentiation and myelination during the myelination process. The downregulation of Ate1 affects OL processes and branching complexity.
Article
Biochemistry & Molecular Biology
Klaire Yixin Fjaestad, Anne Mette Askehoj Romer, Victor Goitea, Astrid Zedlitz Johansen, Marie-Louise Thorseth, Marco Carretta, Lars Henning Engelholm, Lars Grontved, Niels Junker, Daniel Hargbol Madsen
Summary: The development of immune checkpoint inhibitors (ICI) has been an important breakthrough in cancer therapies, but only a limited number of patients benefit from them. Recently, the nonselective beta blocker propranolol has been shown to be effective in treating angiosarcoma and soft tissue sarcomas. It works by reducing tumor angiogenesis and promoting an anti-tumoral microenvironment with increased T cell infiltration. The combination of propranolol with immune checkpoint inhibitors can significantly enhance their efficacy.
Article
Cell Biology
Stine M. Praestholm, Catarina M. Correia, Victor E. Goitea, Majken S. Siersbaek, Mathilde Jorgensen, Jesper F. Havelund, Thomas A. Pedersen, Nils J. Faergeman, Lars Grontved
Summary: The transition from a fasted to a fed state leads to extensive transcriptional remodeling in hepatocytes, with a subset of hepatic feeding-induced genes requiring glucocorticoid receptor (GR) for full expression. This includes the important gene Gck, which is involved in hepatic glucose metabolism. GR cooperatively regulates hepatic Gck expression with insulin in a direct manner, affecting postprandial glucose uptake and storage in the liver.
Article
Genetics & Heredity
Rodrigo O. de Castro, Agustin Carbajal, Luciana Previato de Almeida, Victor Goitea, Courtney T. Griffin, Roberto J. Pezza
Summary: Testis development and germ cell production rely on spermatogonia stem cells. The Chd4 chromatin remodeling complex is important for gene expression and maintenance of spermatogonia stem cells during gamete development.
EPIGENETICS & CHROMATIN
(2022)
Article
Biochemistry & Molecular Biology
Anna Maria Drozd, Luca Mariani, Xiaogang Guo, Victor Goitea, Niels Alvaro Menezes, Elisabetta Ferretti
Summary: Progesterone plays a specific regulatory role in embryonic development by modulating extraembryonic and cardiac mesoderm differentiation. Its function in heart development emphasizes the need for close monitoring of progesterone administration during infertility treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)