Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment

Effect of strenuous exercise on mediators of inflammation in patients with coronary artery disease

(2018) Joanna Cwikiel et al.   CYTOKINE

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury

(2017) Tanya Bogoslovsky et al.   JOURNAL OF NEUROTRAUMA

Minocycline targets multiple secondary injury mechanisms in traumatic spinal cord injury

(2017) Yinghui Zhong et al.   Neural Regeneration Research

Cellular and molecular mechanisms of neuroprotection and plasticity after traumatic brain injury

(2017) Raghu Vemuganti et al.   NEUROCHEMISTRY INTERNATIONAL

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

(2016) Stefano Fais et al.   ACS Nano

Association of Shoulder Problems in Persons With Spinal Cord Injury at Discharge From Inpatient Rehabilitation With Activities and Participation 5 Years Later

(2016) Inge Eriks-Hoogland et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

(2016) Mijung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Q&A: What are exosomes, exactly?

(2016) James R. Edgar   BMC BIOLOGY

Active duty service members who sustain a traumatic brain injury have chronically elevated peripheral concentrations of Aβ40 and lower ratios of Aβ42/40

(2016) Natasha Lejbman et al.   BRAIN INJURY

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

(2016) Kae M. Pusic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Executive Summary: Heart Disease and Stroke Statistics—2016 Update

(2016) Dariush Mozaffarian et al.   CIRCULATION

Exosomes in Human Breast Milk Promote EMT

(2016) W. Qin et al.   CLINICAL CANCER RESEARCH

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's diseasein vitromodel

(2016) Mijung Lee et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Impaired activation of ALS monocytes by exosomes

(2016) Lisa Zondler et al.   IMMUNOLOGY AND CELL BIOLOGY

Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer’s Disease Brain

(2016) Sravani Musunuri et al.   JOURNAL OF ALZHEIMERS DISEASE

Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy

(2016) Robert A. Stern et al.   JOURNAL OF ALZHEIMERS DISEASE

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

Serum biomarkers as predictors of long-term outcome in severe traumatic brain injury: analysis from a randomized placebo-controlled Phase II clinical trial

(2016) Amol Raheja et al.   JOURNAL OF NEUROSURGERY

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

(2016) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

(2016) Kyle B. Fraser et al.   MOVEMENT DISORDERS

Loss of exosomes in progranulin-associated frontotemporal dementia

(2016) Luisa Benussi et al.   NEUROBIOLOGY OF AGING

In support of an individualized approach to assessing quality of life: comparison between Patient Generated Index and standardized measures across four health conditions

(2016) Nancy E. Mayo et al.   QUALITY OF LIFE RESEARCH

Characterization of Induced Pluripotent Stem Cell Microvesicle Genesis, Morphology and Pluripotent Content

(2016) Jing Zhou et al.   Scientific Reports

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD

(2016) Thomas Westergard et al.   Cell Reports

Optimization of a 3D Dynamic Culturing System for In Vitro Modeling of Frontotemporal Neurodegeneration-Relevant Pathologic Features

(2016) Marta Tunesi et al.   Frontiers in Aging Neuroscience

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia

(2016) Daan R.M.G. Ophelders et al.   Stem Cells Translational Medicine

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche

(2016) Alejandro Luarte et al.   Stem Cells International

Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation

(2016) Emily B. Harrison et al.   FEBS Open Bio

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Increased Brain-Specific MiR-9 and MiR-124 in the Serum Exosomes of Acute Ischemic Stroke Patients

(2016) Qiuhong Ji et al.   PLoS One

Smartphone-enabled optofluidic exosome diagnostic for concussion recovery

(2016) Jina Ko et al.   Scientific Reports

Emerging potential of exosomes and noncoding microRNAs for the treatment of neurological injury/diseases

(2015) Michael Chopp et al.   EXPERT OPINION ON EMERGING DRUGS

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease

(2015) Dimitrios Kapogiannis et al.   FASEB JOURNAL

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia

(2015) Junhong Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Exosome-mediated inflammasome signaling after central nervous system injury

(2015) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF NEUROCHEMISTRY

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

(2015) Paul M. George et al.   NEURON

The 3 Rs of Stroke Biology: Radial, Relayed, and Regenerative

(2015) S. Thomas Carmichael   Neurotherapeutics

Chromatographically isolated CD63+CD81+extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI

(2015) Dong-ki Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Exosomes in human semen restrict HIV-1 transmission by vaginal cells and block intravaginal replication of LP-BM5 murine AIDS virus complex

(2015) Marisa N. Madison et al.   VIROLOGY

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126

(2015) Fan Chen et al.   Translational Stroke Research

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Extracellular vesicles as emerging intercellular communicasomes

(2014) Yae Jin Yoon et al.   BMB Reports

Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury

(2014) Zhen Zhang et al.   BRAIN RESEARCH

Identification of Double-stranded Genomic DNA Spanning All Chromosomes with MutatedKRASandp53DNA in the Serum Exosomes of Patients with Pancreatic Cancer

(2014) Christoph Kahlert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tenascins in stem cell niches

(2014) Ruth Chiquet-Ehrismann et al.   MATRIX BIOLOGY

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Exosome platform for diagnosis and monitoring of traumatic brain injury

(2014) D. D. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Personality changes and return to work after severe traumatic brain injury: a prospective study

(2014) Alexandre P. Diaz et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

let-7 miRNAs Can Act through Notch to Regulate Human Gliogenesis

(2014) M. Patterson et al.   Stem Cell Reports

Global prevalence and incidence of traumatic spinal cord injury

(2014) Michael Fehlings et al.   Clinical Epidemiology

Pathogenesis of acute stroke and the role of inflammasomes

(2013) David Yang-Wei Fann et al.   AGEING RESEARCH REVIEWS

Current methods for the isolation of extracellular vesicles

(2013) Fatemeh Momen-Heravi et al.   BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Cerebrospinal fluid biomarkers in Alzheimer’s disease, vascular dementia and ischemic stroke patients: a critical analysis

(2013) Lisa Kaerst et al.   JOURNAL OF NEUROLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

(2013) Huan-Dong Liu et al.   NEUROCHEMICAL RESEARCH

Inhibiting PTEN Protects Hippocampal Neurons against Stretch Injury by Decreasing Membrane Translocation of AMPA Receptor GluR2 Subunit

(2013) Yuan Liu et al.   PLoS One

Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced Colitis

(2013) Chil-sung Kang et al.   PLoS One

Understanding Stroke Survivorship

(2013) Lesli E. Skolarus et al.   STROKE

miR-9: a versatile regulator of neurogenesis

(2013) Marion Coolen et al.   Frontiers in Cellular Neuroscience

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

(2012) Stephanie Adamczak et al.   JOURNAL OF NEUROSURGERY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells

(2012) Susanna Tomasoni et al.   STEM CELLS AND DEVELOPMENT

Emerging Roles of Exosomes in Neuron–Glia Communication

(2012) Carsten Frühbeis et al.   Frontiers in Physiology

Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

(2011) Yuko Ogawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cytokine changes in the pathophysiology of poststroke depression

(2011) Jian-An Su et al.   GENERAL HOSPITAL PSYCHIATRY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

MicroRNA Profiling in Subventricular Zone after Stroke: MiR-124a Regulates Proliferation of Neural Progenitor Cells through Notch Signaling Pathway

(2011) Xian Shuang Liu et al.   PLoS One

Early Biomarkers of Clinical–Diffusion Mismatch in Acute Ischemic Stroke

(2011) Manuel Rodríguez-Yáñez et al.   STROKE

Molecular Pathophysiology of Cerebral Hemorrhage

(2011) Jaroslaw Aronowski et al.   STROKE

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke

(2010) Antonino Tuttolomondo et al.   ATHEROSCLEROSIS

The Epidemiology of Traumatic Brain Injury

(2010) John D. Corrigan et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

(2010) Adan Aguirre et al.   NATURE

PICK1-mediated GluR2 endocytosis contributes to cellular injury after neuronal trauma

(2009) J D Bell et al.   CELL DEATH AND DIFFERENTIATION

Motor rehabilitation after stroke, traumatic brain, and spinal cord injury: common denominators within recent clinical trials

(2009) Bruce H Dobkin   CURRENT OPINION IN NEUROLOGY

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

(2009) Mehmet Kesimer et al.   FASEB JOURNAL

Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins

(2009) Mariana Regente et al.   FEBS LETTERS

Cerebrospinal Fluid Inflammatory Cytokines and Biomarkers of Injury Severity in Acute Human Spinal Cord Injury

(2009) Brian K. Kwon et al.   JOURNAL OF NEUROTRAUMA

Differentiating ischemic stroke subtypes: Risk factors and secondary prevention

(2009) Howard S. Kirshner   JOURNAL OF THE NEUROLOGICAL SCIENCES

Temporal–spatial expression of presenilin 1 and the production of amyloid-β after acute spinal cord injury in adult rat

(2009) S. Kobayashi et al.   NEUROCHEMISTRY INTERNATIONAL

Vesicular transport inHistoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes

(2008) Priscila Costa Albuquerque et al.   CELLULAR MICROBIOLOGY

Post-ischemic brain damage: pathophysiology and role of inflammatory mediators

(2008) Diana Amantea et al.   FEBS Journal

MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

(2008) Douglas D. Taylor et al.   GYNECOLOGIC ONCOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Heart Disease and Stroke Statistics—2008 Update

(2007) et al.   CIRCULATION