期刊
JOURNAL OF NEUROLOGY
卷 260, 期 11, 页码 2722-2727出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-013-7047-3
关键词
CSF; Biomarkers; A beta; Tau; Alzheimer's disease; Vascular dementia; Stroke
资金
- JPND program [DEMTEST (Biomarker based diagnosis of rapid progressive dementias-optimisation of diagnostic protocols) [01ED1201A]
- Federal Ministry of Education and Research grant within the German Network for Degenerative Dementia [KNDD-2]
Vascular factors are thought to contribute to the development of disease pathology in neurodegenerative dementia such as Alzheimer's disease (AD). Another entity, called vascular dementia (VaD), comprises a less defined group of dementia patients having various vascular diseases that especially emerge in the elderly population and require valid options for examination and differential diagnosis. In the context of a retrospective study, we analyzed the cerebrospinal fluid (CSF) biomarkers t-tau, p-tau and A42 of a total of 131 patients with AD (n = 47), mild cognitive impairment (MCI) (n = 22), VaD (n = 44) and stroke (n = 18). We found a remarkable alteration in CSF biomarker profile in AD, VaD and in acute ischemic events. CSF profile in AD patients was altered in a very similar way as in stroke patients, without statistical differences. In stroke, increase depend largely on size and duration after the initial event. Total tau levels were useful to differ between VaD and stroke. A42 decreased in a similar way in AD, VaD and stroke and had a trend to lower levels in MCI but not in controls.
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