The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization

Coordinate effects of P2X7 and extracellular acidification in microglial cells

(2018) Ponarulselvam Sekar et al.   Oncotarget

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation

(2017) Myungjin Jo et al.   JOURNAL OF NEUROSCIENCE

The pattern recognition receptor, Mincle, is essential for maintaining the M1 macrophage phenotype in acute renal inflammation

(2017) Lin L. Lv et al.   KIDNEY INTERNATIONAL

Immunization with Bacillus Calmette-Guérin (BCG) alleviates neuroinflammation and cognitive deficits in APP/PS1 mice via the recruitment of inflammation-resolving monocytes to the brain

(2017) Zejie Zuo et al.   NEUROBIOLOGY OF DISEASE

Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk

(2017) Chisato Honjoh et al.   Scientific Reports

Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells

(2016) Hui Yin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life

(2016) Junhua Yang et al.   BRAIN RESEARCH BULLETIN

An atypical role for the myeloid receptor Mincle in central nervous system injury

(2016) Thiruma V Arumugam et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mincle suppresses Toll-like receptor 4 activation

(2016) Stephanie H. Greco et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neonatal Bacillus Calmette-Guérin vaccination alleviates lipopolysaccharide-induced neurobehavioral impairments and neuroinflammation in adult mice

(2016) Junhua Yang et al.   Molecular Medicine Reports

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

(2016) Li Du et al.   MOLECULAR NEUROBIOLOGY

Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution

(2016) Wook-Bin Lee et al.   Nature Communications

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

C-type lectins in immunity: recent developments

(2015) Ivy M Dambuza et al.   CURRENT OPINION IN IMMUNOLOGY

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization

(2015) Ying-Cing Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mincle Signaling in the Innate Immune Response after Traumatic Brain Injury

(2015) Juan Carlos de Rivero Vaccari et al.   JOURNAL OF NEUROTRAUMA

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats

(2015) Yue He et al.   STROKE

Neonatal vaccination with bacille Calmette-Guérin promotes the dendritic development of hippocampal neurons

(2015) Qingqing Li et al.   Human Vaccines & Immunotherapeutics

C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation

(2014) Xue-Qiang Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1

(2014) Woo Seok Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mycobacterium bovis Bacille Calmette-Guerin Infection in the CNS Suppresses Experimental Autoimmune Encephalomyelitis and Th17 Responses in an IFN- -Independent Manner

(2014) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBPβ and HIF1α

(2014) Hanne Schoenen et al.   JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS

(2014) S. R. Brenner et al.   NEUROLOGY

A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human

(2014) Jaap T. van Dissel et al.   VACCINE

Therapeutic Vaccination Using Cationic Liposome-Adjuvanted HIV Type 1 Peptides Representing HLA-Supertype-Restricted Subdominant T Cell Epitopes: Safety, Immunogenicity, and Feasibility in Guinea-Bissau

(2013) Victor Raúl Gómez Román et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

AMPKα1 Regulates Macrophage Skewing at the Time of Resolution of Inflammation during Skeletal Muscle Regeneration

(2013) Rémi Mounier et al.   Cell Metabolism

Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

(2013) Goran Laćan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3

(2013) Y.-C. Lin et al.   Science Signaling

Involvement of Mincle and Syk in the changes to innate immunity after ischemic stroke

(2013) Yukiya Suzuki et al.   Scientific Reports

Ginsenoside Rg1 Attenuates Lipopolysaccharide-Induced Inflammatory Responses Via the Phospholipase C-γ1 Signaling Pathway in Murine BV-2 Microglial Cells

(2012) Y. Zong et al.   CURRENT MEDICINAL CHEMISTRY

Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity

(2012) Dominikus Strasser et al.   IMMUNITY

Calcium/Calmodulin-dependent Protein Kinase Kinase 2 Regulates Macrophage-mediated Inflammatory Responses

(2012) Luigi Racioppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small Cationic DDA:TDB Liposomes as Protein Vaccine Adjuvants Obviate the Need for TLR Agonists in Inducing Cellular and Humoral Responses

(2012) Anita Milicic et al.   PLoS One

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

(2012) Rongze Lu et al.   PLoS Pathogens

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Bioenergy sensing in the brain

(2011) Stephen Amato et al.   CELL CYCLE

Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages

(2011) Chen-Chun Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

(2010) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Ultrasound stimulates NF-κB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts

(2009) Chun-Han Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adjuvanticity of a synthetic cord factor analogue for subunitMycobacterium tuberculosisvaccination requires FcRγ–Syk–Card9–dependent innate immune activation

(2009) Kerstin Werninghaus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis

(2009) N. Nath et al.   JOURNAL OF IMMUNOLOGY

Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells

(2008) Regina A. Oyesanya et al.   FASEB JOURNAL

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

(2008) Else Marie Agger et al.   PLoS One