Article
Immunology
Huanghui Wu, Han Bao, Cong Liu, Qiao Zhang, Ailing Huang, Minxue Quan, Chunhui Li, Ying Xiong, Guozhong Chen, Lichao Hou
Summary: This study investigated the role and mechanism of extracellular nucleosomes and histones, as damage-associated molecular patterns (DAMPs), in progressive neuroinflammation and chronic stress-related emotional disorders. It found that extracellular nucleosomes accelerate microglial inflammation via Clec2d and TLR9, contributing to chronic stress-induced emotional disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K. Mishra, Janet A. Willment, Gordon D. Brown, Masamichi Nagae, Sho Yamasaki
Summary: This study reports that human Dectin-1 acts as a ligand for CLEC-2 and highlights the importance of glycosylation in its function as a CLEC-2 ligand. Furthermore, it is shown that expression of human Dectin-1 can rescue the lethality and lymphatic defect resulting from a deficiency of Podoplanin.
Article
Immunology
Tianhang Li, Tianyao Liu, Zihan Zhao, Yuchen Pan, Xinyan Xu, Yulin Zhang, Shoubin Zhan, Shengkai Zhou, Wenjie Zhu, Hongqian Guo, Rong Yang
Summary: Immunotherapies offer new treatment options for urothelial bladder cancer, but their efficacy is limited by heterogeneity and therapeutic resistance. Research has shown that the commensal microbiota and its interactions with host immunity play a crucial role in bladder cancer. The urinary mycobiome and C-type lectin receptors (CLRs) may be potential targets for immunotherapy in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jan Dohnalek, Tereza Skalova
Summary: The C-type lectin-like fold (CTL fold) is a versatile structural motif found in many proteins, and its interactions play significant roles in various biological processes. Understanding the rules governing these interactions can aid in the development of new protein binders for biomedical and biotechnological applications.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Fisheries
Yang Liu, Zuzhen Wang, Wenjun Wang, Bing Liu, Chunfang Li, Yuandong Sun, Jiri Cao, Kuanyu Xia, Moci Yang, Jinpeng Yan
Summary: In this study, a novel C-type lectin (MaCTL) was cloned and characterized, which plays significant roles in innate immune response through binding to the pathogen-associated molecular patterns (PAMPs) on microorganisms. The results showed that MaCTL is widely expressed in various tissues and upregulated after LPS stimulation and Aeromonas hydrophila challenge, suggesting its involvement in innate immune response. Furthermore, MaCTL can bind to various bacteria and carbohydrates, and exhibit antimicrobial effects.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaohan Liu, Jiqing Gao, Xiao Wei, Xinze Zhang, Liping You, Yuanjin Liu, Lizhu Chen, Caili Liu, Chunxiao Sun, Xiuhui Tian, Quanli Zhou, Xiaomin Zhang
Summary: In this study, the potential mechanisms of PAMP binding and opsonic activities of a c-type lectin and a sialic acid-binding lectin from manila clam were investigated. The results showed that both lectins could bind to various pathogen-associated molecular patterns (PAMPs) and enhance the phagocytosis and encapsulation ability of hemocytes. These lectins may function as pattern recognition receptors (PRRs) involved in the innate immune responses of the clam.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Microbiology
Axel Dietschmann, Sebastian Schruefer, Stefanie Westermann, Fiona Henkel, Kirstin Castiglione, Ralf Willebrand, Jasmin Adam, Jurgen Ruland, Roland Lang, Donald C. Sheppard, Julia Esser-von-Bieren, Daniel Radtke, Sven Krappmann, David Voehringer
Summary: Eosinophilia is associated with various inflammatory diseases, such as allergic bronchopulmonary aspergillosis (ABPA). It has been shown that direct interaction between eosinophils and Aspergillus fumigatus is essential for the activation of eosinophils, which then secrete multiple proinflammatory mediators. The PI3K-AKT-mTOR pathway plays a crucial role in A. fumigatus-induced eosinophil activation.
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Cell Biology
Hiroyasu Ishikura, Yuhei Irie, Masahide Kawamura, Kota Hoshino, Yoshihiko Nakamura, Mariko Mizunuma, Junichi Maruyama, Maiko Nakashio, Katsue Suzuki-Inoue, Taisuke Kitamura
Summary: The level of C-type lectin-like receptor 2 (CLEC-2) is associated with the degree of coagulation disorder in septic patients, indicating its potential as a predictive marker for thrombotic predisposition. By calculating the sCLEC-2/platelet count ratio (C2PAC index), the coagulation status of patients can be accurately assessed.
Article
Fisheries
Crystal Guluarte, Martha Reyes-Becerril, Sergio Rosales-Mendoza, Carlos Angulo
Summary: This study analyzed the MINCLE receptor in Pacific red snapper and investigated the stimulating effects of beta-glucans and antigenic proteins on immune cells. The results showed that beta-glucans enhanced respiratory burst activity and nitric oxide production, and up-regulated receptor and pro-inflammatory cytokine gene expression. These findings highlight the significance of beta-glucans and their receptors in the innate immune response.
AQUACULTURE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ankur Midha, Guillaume Goyette-Desjardins, Felix Goerdeler, Oren Moscovitz, Peter H. Seeberger, Karsten Tedin, Luca D. Bertzbach, Bernd Lepenies, Susanne Hartmann
Summary: Ascariasis is a global health issue affecting both humans and animals, with adult Ascaris nematodes forming chronic infections in the host intestine by interacting with host cells and the microbiota. The parasite-secreted protein AsCTL-42 plays a role in the triad relationship between Ascaris, host cells, and the microbiota, by neutralizing bacterial cells without killing them and reducing invasion of intestinal epithelial cells by Salmonella.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Francois Bulteau, Michel Thepaut, Maxime Henry, Amandine Hurbin, Laetitia Vanwonterghem, Corinne Vives, Aline Le Roy, Christine Ebel, Olivier Renaudet, Franck Fieschi, Jean-Luc Coll
Summary: This study found that recombinant MGL fragments can efficiently target Tn-positive human tumors without inducing toxicity, making it a promising candidate for in vivo diagnosis and imaging of human tumors and potentially for therapeutic applications.
MOLECULAR PHARMACEUTICS
(2022)
Article
Entomology
Hao Li, Fang-Fang Liu, Li-Qing Fu, Ze Liu, Wen-Ting Zhang, Qian Wang, Xiang-Jun Rao
Summary: The study identified C-type lectins in the oriental armyworm and investigated their expression patterns in different developmental stages and immune responses, indicating their importance in the immune responses of Mythimna separata.
Article
Fisheries
Li Wang, Jie Zhang, Xianliang Zhao, Chao Pei, Li Li, Xianghui Kong
Summary: The study identified a C-type lectin receptor gene named CaCLR in Qihe crucian carp, which plays a crucial role in the immune system by enhancing the elimination capacity against A. hydrophila.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Zhiqiang Zhang, Xinchao Liu, Qi Li, Miao Xie, Yongxiong Huang, Baijian Jiang, Xing Li, Yu Huang, Jichang Jian
Summary: This study identified a hepatic lectin molecule from Nile tilapia and uncovered its functions in the tilapia immune response to bacteria. The hepatic lectin plays a crucial role in recognizing and agglutinating pathogens, and it is primarily expressed in nonspecific cytotoxic cells and monocytes/macrophages. Blocking hepatic lectin significantly affects the antibacterial immune responses in tilapia.
Article
Biochemistry & Molecular Biology
Adrian M. Seifert, Charlotte Reiche, Max Heiduk, Anna Tannert, Ann-Christin Meinecke, Stephanie Baier, Janusz von Renesse, Christoph Kahlert, Marius Distler, Thilo Welsch, Christoph Reissfelder, Daniela E. Aust, George Miller, Juergen Weitz, Lena Seifert
Article
Health Care Sciences & Services
Vishnu R. Mani, Aleksandr Kalabin, Sebastian C. Valdivieso, Max Murray-Ramcharan, Brian Donaldson
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Correction
Oncology
Wei Wang, Jill M. Marinis, Allison M. Beal, Shivraj Savadkar, Yue Wu, Mohammed Khan, Pardeep S. Taunk, Nan Wu, Wenyu Su, Jingjing Wu, Aarif Ahsan, Emma Kurz, Ting Chen, Inedouye Yaboh, Fei Li, Johana Gutierrez, Brian Diskin, Mautin Hundeyin, Michael Reilly, John D. Lich, Philip A. Harris, Mukesh K. Mahajan, James H. Thorpe, Pamela Nassau, Julie E. Mosley, Joshua Leinwand, Juan A. Kochen Rossi, Ankita Mishra, Berk Aykut, Michael Glacken, Atsuo Ochi, Narendra Verma, Jacqueline I. Kim, Varshini Vasudevaraja, Dennis Adeegbe, Christina Almonte, Ece Bagdatlioglu, Deirdre J. Cohen, Kwok-Kin Wong, John Bertin, George Miller
Correction
Multidisciplinary Sciences
Lena Seifert, Gregor Werba, Shaun Tiwari, Nancy Ngoc Giao Ly, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Rocky Barilla, Donnele Daley, Stephanie H. Greco, Alejandro Torres-Hernandez, Matthew Pergamo, Atsuo Ochi, Constantinos P. Zambirinis, Mridul Pansari, Mauricio Rendon, Daniel Tippens, Mautin Hundeyin, Vishnu R. Mani, Cristina Hajdu, Dannielle Engle, George Miller
Article
Biology
A. Thirumal Raj, Supriya Kheur, Ramesh Bhonde, Vishnu R. Mani, Hosam Ali Baeshen, Shankargouda Patil
Summary: The secretome of dental pulp mesenchymal stem cells may have pro-carcinogenic effects on oral cancer, breast cancer, and melanoma cells by upregulating growth factors and cytokines to enhance invasion and drug resistance properties of these cancer cells. Further animal model studies are needed to validate these in-vitro findings.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Correction
Biochemistry & Molecular Biology
Donnele Daley, Vishnu R. Mani, Navyatha Mohan, Neha Akkad, Atsuo Ochi, Daniel W. Heindel, Ki Buom Lee, Constantinos P. Zambirinis, Gautam S. D. Balasubramania Pandian, Shivraj Savadkar, Alejandro Torres-Hernandez, Shruti Nayak, Ding Wang, Mautin Hundeyin, Brian Diskin, Berk Aykut, Gregor Werba, Rocky M. Barilla, Robert Rodriguez, Steven Chang, Lawrence Gardner, Lara K. Mahal, Beatrix Ueberheide, George Miller
Article
Infectious Diseases
Hassan Ashktorab, Antonio Pizuorno, Folake Adeleye, Adeyinka Laiyemo, Maryam Mehdipour Dalivand, Farshad Aduli, Zaki A. Sherif, Gholamreza Oskrochi, Kibreab Angesom, Philip Oppong-Twene, Suryanarayana Reddy Challa, Nnaemeka Okorie, Esther S. Moon, Edward Romos, Boubini Jones-Wonni, Abdoul Madjid Kone, Sheldon Rankine, Camelita Thrift, Derek Scholes, Chiamaka Ekwunazu, Abigail Banson, Brianna Mitchell, Guttu Maskalo, Jillian Ross, Julencia Curtis, Rachel Kim, Chandler Gilliard, Geetha Ahuja, Joseph Mathew, Warren Gavin, Areeba Kara, Manuel Hache-Marliere, Leonidas Palaiodimos, Vishnu R. Mani, Aleksandr Kalabin, Vijay Reddy Gayam, Pavani Reddy Garlapati, Joseph Miller, Lakshmi Gayathri Chirumamilla, Fatimah Jackson, John M. Carethers, Farin Kamangar, Hassan Brim
Summary: This study used a large cohort of hospitalized COVID-19 patients to determine predictors of mortality. The findings showed higher mortality rates among African Americans compared to other races, which may be attributed to a higher frequency of comorbidities and older age. The use of glucocorticoids should be approached with caution, and special attention should be given to treating patients with elevated liver enzymes and other inflammatory biomarkers.
BMC INFECTIOUS DISEASES
(2022)
Correction
Infectious Diseases
Hassan Ashktorab, Antonio Pizuorno, Folake Adeleye, Adeyinka Laiyemo, Maryam Mehdipour Dalivand, Farshad Aduli, Zaki A. Sherif, Gholamreza Oskrochi, Kibreab Angesom, Philip Oppong-Twene, Suryanarayana Reddy Challa, Nnaemeka Okorie, Esther S. Moon, Edward Romos, Boubini Jones-Wonni, Abdoul Madjid Kone, Sheldon Rankine, Camelita Thrift, Derek Scholes, Chiamaka Ekwunazu, Abigail Banson, Brianna Mitchell, Guttu Maskalo, Jillian Ross, Julencia Curtis, Rachel Kim, Chandler Gilliard, Geeta Ahuja, Joseph Mathew, Warren Gavin, Areeba Kara, Manuel Hache-Marliere, Leonidas Palaiodimos, Vishnu R. Mani, Aleksandr Kalabin, Vijay Reddy Gayam, Pavani Reddy Garlapati, Joseph Miller, Lakshmi Gayathri Chirumamilla, Fatimah Jackson, John M. Carethers, Farin Kamangar, Hassan Brim
BMC INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Aleksandr Kalabin, Vishnu R. Mani, Robin L. Kruse, Chase Schlesselman, Kai Yu Li, Kevin F. Staveley-O'Carroll, Eric T. Kimchi
Summary: Pancreatic ductal adenocarcinoma is a common malignancy with poor prognosis. A robotic platform has recently been used for treating pancreatic cancer, but data on long-term outcomes are insufficient. This study aimed to evaluate lymph node harvest during robotic pancreaticoduodenectomy (PD) and its association with short- and long-term oncological outcomes.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Urology & Nephrology
Vishnu R. Mani, Sebastian C. Valdivieso, Adel Hanandeh, Aleksandr Kalabin, Alexius Ramcharan, Brian Donaldson
Summary: The passage highlights the increasing prevalence of transgender surgeries globally and in the United States, while also pointing out the lack of education on psychosocial needs, medical pathophysiology, surgical procedures, and complications related to transgender medicine in regular medical curriculum. It emphasizes the importance of exposing practicing physicians to transgender medicine through continuing medical education to address health disparities within the LGBTQ community.
Correction
Biochemistry & Molecular Biology
Donnele Daley, Constantinos Pantelis Zambirinis, Lena Seifert, Neha Akkad, Navyatha Mohan, Gregor Werba, Rocky Barilla, Alejandro Torres-Hernandez, Mautin Hundeyin, Vishnu Raj Kumar Mani, Antonina Avanzi, Daniel Tippens, Rajkishen Narayanan, Jung-Eun Jang, Elliot Newman, Venu Gopal Pillarisetty, Michael Loran Dustin, Dafna Bar-Sagi, Cristina Hajdu, George Miller
Meeting Abstract
Surgery
Vishnu Raj Kumar Mani, Aleksandr Kalabin, Sebastian Cristobal Valdivieso, Suresh Agarwal, Leaque Ahmed, Javier Enrique Andrade, Stephen S. Carryl
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Meeting Abstract
Surgery
Vishnu Raj Kumar Mani, Aleksandr Kalabin, Taha Rashid Mallick, Suresh Agarwal, Stephen S. Carryl, Leaque Ahmed
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2020)
Article
Medicine, General & Internal
Adel Hanandeh, Vishnu R. Mani, Paul Bauer, Alexius Ramcharan, Brian Donaldson
CUREUS JOURNAL OF MEDICAL SCIENCE
(2019)