Review
Biochemistry & Molecular Biology
Eduardo Duran-Jara, Tamara Vera-Tobar, Lorena De Lourdes Lobos-Gonzalez
Summary: Lactadherin is associated with cancer development and progression, and can serve as a biomarker and therapeutic target for cancer. It plays important roles in cell adhesion, angiogenesis, and tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Junping Zhang, Xiaoping Cai, Weifeng Cui, Zheng Wei
Summary: The study found that MAP4K4 is significantly overexpressed in gastric cancer tissues compared to normal tissues, and its high expression is closely associated with tumor-related pathways. Further immune infiltration analysis showed a positive correlation between immune scores and MAP4K4 expression. The study also identified potential negative regulatory effects of miRNAs on MAP4K4.
Review
Pathology
Xuemei Zeng, Juan Xiao, Xue Bai, Yiwen Liu, Meilan Zhang, Jiangrong Liu, Zixuan Lin, Zhiwei Zhang
Summary: Gastric cancer is a common malignant tumor, and genetic and epigenetic alterations play a key role in its development and resistance to chemotherapy. Recent studies have revealed that circRNA/lncRNA indirectly regulate miRNA downstream target genes, thus influencing the malignant behavior of gastric cancer. Exosomal non-coding RNAs also play an important role in the diagnosis, prognosis, and treatment of gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Xiangliu Chen, Haiyong Wang, Yingying Huang, Yanyan Chen, Chuanzhi Chen, Wei Zhuo, Lisong Teng
Summary: This review provides new insights into the molecular signatures of GC-associated exosomes in reprogramming the tumor microenvironment and promoting peritoneal metastasis, including infiltration of the gastric wall, implantation of tumor cells onto the pre-metastatic peritoneum, and remodeling of the pre-metastatic niche. Based on this review, a more general conclusion about the functions of exosomes in GC progression and peritoneal metastasis is drawn, with a focus on future strategies targeting exosomes for prognostic biomarkers and therapy for peritoneal metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xiaolin Wang, Jiahui Zhang, Guozhen Cao, Jinghan Hua, Ge Shan, Wenchu Lin
Summary: Gastric cancer is an aggressive malignancy with a high mortality rate primarily caused by metastatic lesions. Recent studies have shown that covalently closed circular RNAs (circRNAs) play crucial roles in gastric cancer, exhibiting dysregulated patterns in invasion and metastasis. However, the specific functions of circRNAs in metastatic gastric cancer remain unclear. This review outlines the functional circRNAs related to metastatic gastric cancer and drug resistance, providing insights into their underlying mechanisms and potential for future therapeutic interventions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Dwaipayan Dey, Srestha Ghosh, Divya Mirgh, Siva Parsad Panda, Niraj Kumar Jha, Saurabh Kumar Jha
Summary: This review discusses the role of exosomes in prostate cancer and their association with male fertility.
DRUG DISCOVERY TODAY
(2023)
Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Oana Baldasici, Valentina Pileczki, Daniel Cruceriu, Laura Ioana Gavrilas, Oana Tudoran, Loredana Balacescu, Laurian Vlase, Ovidiu Balacescu
Summary: Metastasis is the leading cause of breast cancer-related mortality, and efforts are being made to identify blood-based biomarkers that can distinguish highly metastatic cancer patients. Exosomal miRNAs hold promise as prognostic biomarkers for metastatic breast cancer and have shown potential in both research and clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Linda Hofmann, Malgorzata Harasymczuk, Diana Huber, Miroslaw J. Szczepanski, Grzegorz Dworacki, Theresa L. Whiteside, Marie-Nicole Theodoraki
Summary: Arginase-1 plays an important role in the clinicopathology and prognosis of head and neck cancer. High tumor Arginase-1 levels are associated with favorable clinicopathology and prognosis, while high plasma Arginase-1 levels are associated with unfavorable clinicopathology. The presence of Arginase-1 in exosomes explains this discrepancy. High levels of exosomal Arginase-1 are associated with lymph node metastasis and shorter recurrence-free survival.
Review
Oncology
Larissa Kotelevets, Eric Chastre
Summary: Extracellular vesicles, such as exosomes, ectosomes, and apoptotic bodies, play a critical role in intercellular communication and can be used for noninvasive diagnosis of cancer. They can also be engineered for efficient delivery of therapeutic agents for tumor treatment. This review highlights the importance of extracellular vesicles in colorectal cancer progression, diagnosis, and potential therapeutic approaches.
Review
Oncology
Sreerenjini Lakshmi, Thomas A. Hughes, Sulochana Priya
Summary: Exosomes and their RNA have potential roles in breast cancer biology and treatment, participating in breast cancer tumorigenesis and progression through the transfer of miRNAs and LncRNAs. The diagnostic and therapeutic applications of exosomal miRNAs/LncRNAs in breast cancer have been highlighted in numerous publications.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Jung Hwan Yoon, Byung Joon Choi, Suk Woo Nam, Won Sang Park
Summary: This study found that exosomes derived from gastric cancer cells can affect the fate of surrounding gastric epithelial cells. Gastric cancer exosomes promote cell survival and proliferation while inhibiting cellular senescence and apoptosis. The exosomes also regulate the expression of telomere-related genes, heat-shock genes, and hedgehog genes.
Article
Oncology
Cheng Zhang, Jing Yang, Yang Chen, Fangli Jiang, Haiyan Liao, Xiang Liu, Yuan Wang, Guanyi Kong, Xiaotian Zhang, Jian Li, Jing Gao, Lin Shen
Summary: This study investigated biomarkers for organo-tropic metastasis of gastric cancer (GC) from the perspective of small extracellular vesicle (sEV)-derived miRNAs. The expression profiles of sEV-miRNAs varied greatly across different metastatic patterns, and signatures were constructed to characterize and predict organo-tropic metastasis. The study also explored the impact of these biomarker miRNAs on GC's in vitro motility and discussed their potential involvement in cancer-related biological processes and pathways.
Review
Immunology
MingHua Cui, YueHui Liu, Li Cheng, Tao Li, YongZhi Deng, Da Liu
Summary: Ovarian cancer is a highly deadly malignancy among women, and its complex pathogenesis remains largely unknown. The tumor microenvironment plays a crucial role in tumor progression and treatment. MicroRNAs have been shown to regulate ovarian cancer development by affecting the tumor microenvironment. Therefore, identifying new tumor biomarkers and therapeutic targets is of great significance for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Joshua Miguel C. Danac, Aileen Geobee G. Uy, Reynaldo L. Garcia
Summary: The journey of cancer cells from a primary tumor to distant sites involves cellular reprogramming, breaking of physical barriers, and preparation of pre-metastatic niches. Tumor-derived exosomes carrying miRNAs play important roles in the metastatic cascade, but their specific functions are still being characterized.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Rongxue Zhang, Yuan Zhu, Yang Li, Wanzhu Liu, Lei Yin, Siqi Yin, Cheng Ji, Yuyan Hu, Qiongni Wang, Xinru Zhou, Jingyan Chen, Wenrong Xu, Hui Qian
BIOTECHNOLOGY LETTERS
(2020)
Article
Biotechnology & Applied Microbiology
Wei Li, Jianling Liu, Bin Zhang, Qingli Bie, Hui Qian, Wenrong Xu
ONCOTARGETS AND THERAPY
(2020)
Article
Immunology
Gaoying Wang, Mbobda Defo Marius Joel, Jintao Yuan, Jingyan Wang, Xiu Cai, Dickson Kofi Wiredu Ocansey, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao
INFLAMMOPHARMACOLOGY
(2020)
Article
Biology
Dickson K. W. Ocansey, Li Zhang, Yifei Wang, Yongmin Yan, Hui Qian, Xu Zhang, Wenrong Xu, Fei Mao
BIOLOGICAL REVIEWS
(2020)
Article
Oncology
Meng Shao, Jiayin Zhang, Jiahui Zhang, Hui Shi, Yu Zhang, Runbi Ji, Fei Mao, Hui Qian, Wenrong Xu, Xu Zhang
CANCER CELL INTERNATIONAL
(2020)
Review
Oncology
Zhaofeng Liang, Wenhao Guo, Shikun Fang, Yue Zhang, Ling Lu, Wenrong Xu, Hui Qian
Summary: circRNAs, with their covalently closed loop structure, high stability, tissue specificity, and functional diversity, have been identified as potential biomarkers for bladder cancer. They have been shown to function in regulating gene transcription, acting as miRNA sponges, and encoding proteins.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xu Zhang, Hongbo Zhang, Jianmei Gu, Jiayin Zhang, Hui Shi, Hui Qian, Dongqing Wang, Wenrong Xu, Jianming Pan, Helder A. Santos
Summary: Extracellular vesicles (EVs) have shown great potential as a cell-free strategy for cancer therapy, with the ability to be modified and engineered to enhance their therapeutic efficiency and safety. Recent advances have focused on strategies to scale up production, improve cargo-loading, and enhance tumor-targeting of engineered EVs.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Peipei Wu, Bin Zhang, Dickson Kofi Wiredu Ocansey, Wenrong Xu, Hui Qian
Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.
Article
Cell Biology
Xinye Han, Peipei Wu, Linli Li, Hassan Mohamud Sahal, Cheng Ji, Jiahui Zhang, Yi Wang, Qichen Wang, Hui Qian, Hui Shi, Wenrong Xu
Summary: DF-Ex can reverse the damage caused by high glucose in HUVECs and accelerate diabetic cutaneous wound healing; DF-Ex exerts its effects by activating the Akt/beta-catenin pathway; This research provides a new treatment strategy for diabetic cutaneous wound healing.
Article
Cell Biology
Yan Wang, Huiting Wang, Ruiqi Zheng, Peipei Wu, Zixuan Sun, Jingyan Chen, Leilei Zhang, Chenxiao Zhang, Hui Qian, Jiajia Jiang, Wenrong Xu
Summary: In this study, circ-ITCH was found to suppress GC metastasis by acting as a sponge for miR-199a-5p and increasing Klotho expression, providing potential biomarkers and targets for the diagnosis and therapy of GC.
Review
Cell & Tissue Engineering
Qian Jin, Peipei Wu, Xinru Zhou, Hui Qian, Wenrong Xu
Summary: Exosomes, small extracellular vesicles secreted by cells, play crucial roles in intercellular communication in the CNS, contributing to CNS development and homeostasis as well as potentially influencing the progression of neurological disorders. Additionally, exosomes may serve as diagnostic biomarkers and therapeutic tools for these disorders, showing promise in the field of neurological research.
STEM CELLS INTERNATIONAL
(2021)
Article
Oncology
Hui Shi, Yaoxiang Sun, Hongru Ruan, Cheng Ji, Jiahui Zhang, Peipei Wu, Linli Li, Chihan Huang, Yuanwang Jia, Xu Zhang, Wenrong Xu, Jiajia Jiang, Hui Qian
Summary: The study found that the anti-cancer drug DIM at therapeutic concentrations upregulated the expression of tumor-related factors in GC-MSCs and promoted the proliferation, invasion, and migration of gastric cancer cells, leading to tumor growth. This mechanism provides a new insight into anti-cancer drug resistance and suggests the need to adjust the chemotherapy regimen to minimize the side effects of drugs on targeted TME cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Benshuai You, Yang Yang, Zixuan Zhou, Yongmin Yan, Leilei Zhang, Jianhua Jin, Hui Qian
Summary: EVs have shown cardioprotective effects in heart disease by activating beneficial signaling pathways. Engineering approaches have been developed to improve the therapeutic efficiency of EVs, but further optimization is needed to achieve better cardiac repair outcomes.
Review
Pharmacology & Pharmacy
Fengtian Sun, Yuntong Sun, Feng Wu, Wenrong Xu, Hui Qian
Summary: This review introduces the novel cell-free strategy of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) and their applications in the treatment of diabetes mellitus (DM) and diabetic complications. The major characteristics of MSC-EVs are summarized, and the recent advances in the use of engineered MSC-EVs for treating hyperglycemia-induced tissue damage are discussed. Additionally, the potential applications of engineered MSC-EVs in the therapy of DM-related diseases are presented, and the opportunities and challenges for clinical translation of MSC-EVs, particularly engineered MSC-EVs, are evaluated.
Article
Oncology
Cheng Ji, Jiahui Zhang, Zixuan Zhou, Hui Shi, Wanzhu Liu, Fengtian Sun, Chenxiao Zhang, Leilei Zhang, Zixuan Sun, Hui Qian
Summary: The study proposed the therapeutic use of platelet-rich plasma-stimulated mesenchymal stem cells (PRP-MSCs) for acute kidney injury (AKI), showing significant improvement in kidney damage and reduced levels of blood urea nitrogen and creatinine in both in vivo and in vitro studies. The results suggest that PRP can enhance the therapeutic effect of MSCs through a paracrine pathway, offering a promising treatment option for AKI.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
