Modulatory effects of bufalin, an active ingredient from toad venom on voltage-gated sodium channels

Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening

(2016) Marc Rogers et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells

(2016) Jian Shi et al.   FASEB JOURNAL

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1

(2016) Leonid P. Shutov et al.   JOURNAL OF NEUROSCIENCE

Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells

(2016) Jian Shi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Downregulation of ClC-3 in dorsal root ganglia neurons contributes to mechanical hypersensitivity following peripheral nerve injury

(2016) Rui-Ping Pang et al.   NEUROPHARMACOLOGY

BK channels in microglia are required for morphine-induced hyperalgesia

(2016) Yoshinori Hayashi et al.   Nature Communications

Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway

(2016) Fei Liu et al.   Oncotarget

Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways

(2015) Jie Wang et al.   Gastroenterology Research and Practice

Up-Regulatory Effects of Curcumin on Large Conductance Ca2+-Activated K+ Channels

(2015) Qijing Chen et al.   PLoS One

Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

(2014) Lili Wen et al.   MEDIATORS OF INFLAMMATION

Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells

(2014) Lin Jiang et al.   TUMOR BIOLOGY

Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

(2014) Camilla Fusi et al.   Nature Communications

Recombinant Expression and Functional Characterization of Martentoxin: A Selective Inhibitor for BK Channel (α + β4)

(2014) Jie Tao et al.   Toxins

Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities

(2013) Junshan Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells

(2013) WEI GU et al.   ONCOLOGY REPORTS

Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia

(2013) Wenrui Xie et al.   PAIN

Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells

(2013) He Huang et al.   PLoS One

MicroRNA-497 and bufalin act synergistically to inhibit colorectal cancer metastasis

(2013) Yan-yan Qiu et al.   TUMOR BIOLOGY

Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator

(2013) Feng Jiang et al.   Neuroscience Bulletin

Pharmacological kinetics of BmK AS, a sodium channel site 4-specific modulator on Nav1.3

(2012) Zhi-Rui Liu et al.   Neuroscience Bulletin

Effects of resibufogenin on voltage-gated sodium channels in cultured rat hippocampal neurons

(2011) Shuang Hao et al.   NEUROSCIENCE LETTERS

Targeting A-type K+ channels in primary sensory neurons for bone cancer pain in a rat model

(2011) Kai-Zheng Duan et al.   PAIN

Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by BmK neurotoxins

(2011) Zhi-Rui Liu et al.   Protein & Cell

Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor

(2010) Fanghua Qi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

U-shaped dose-dependent effects of BmK AS, a unique scorpion polypeptide toxin, on voltage-gated sodium channels

(2009) Mang-Mang Zhu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY