Targeting Poly (ADP-Ribose) Polymerase Partially Contributes to Bufalin-Induced Cell Death in Multiple Myeloma Cells

Bufalin, a Traditional Oriental Medicine, Induces Apoptosis in Human Cancer Cells

(2012) Noriyuki Takai et al.   Asian Pacific Journal of Cancer Prevention

Olaparib, PARP1 inhibitor in ovarian cancer

(2012) Claudia Marchetti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bufalin Induces Lung Cancer Cell Apoptosis via the Inhibition of PI3K/Akt Pathway

(2012) Zhitu Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors

(2011) P. Neri et al.   BLOOD

Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases

(2011) Jun-Xiang Zhang et al.   HEPATOLOGY

Role of bridging water molecules in GSK3β-inhibitor complexes: Insights from QM/MM, MD, and molecular docking studies

(2011) Shao-Yong Lu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage

(2011) Daniel R. Premkumar et al.   MOLECULAR CARCINOGENESIS

Vorinostat Induces Reactive Oxygen Species and DNA Damage in Acute Myeloid Leukemia Cells

(2011) Luca A. Petruccelli et al.   PLoS One

c-MYC Suppresses BIN1 to Release Poly(ADP-Ribose) Polymerase 1: A Mechanism by Which Cancer Cells Acquire Cisplatin Resistance

(2011) S. Pyndiah et al.   Science Signaling

The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy

(2011) M. Javle et al.   Therapeutic Advances in Medical Oncology

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells

(2010) Fanghua Qi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of (S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

(2010) Thomas D. Penning et al.   JOURNAL OF MEDICINAL CHEMISTRY

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

(2010) Mariam Aghajan et al.   NATURE BIOTECHNOLOGY

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

(2009) Zhiqiang Meng et al.   CANCER

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

ent-Kaurane Diterpenoids fromIsodon pharicus

(2009) Yong Zhao et al.   JOURNAL OF NATURAL PRODUCTS

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells

(2008) Dan Li et al.   ANTI-CANCER DRUGS

Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 Cells

(2008) Ailiang Chen et al.   BIOTECHNOLOGY LETTERS