Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress

Lannea coromandelica (Houtt.) Merr. Induces Heme Oxygenase 1 (HO-1) Expression and Reduces Oxidative Stress via the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway

(2017) Md Alam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)

(2017) Roberto Mioso et al.   MOLECULES

Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms

(2017) Zeina Habli et al.   MOLECULES

Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity

(2017) Anna Lewinska et al.   TOXICOLOGY LETTERS

Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway

(2017) Hsin-Hwa Tsai et al.   Oncotarget

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy

(2017) Nikolaos D. Georgakopoulos et al.   Scientific Reports

Synergy of 2-deoxy-d-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis

(2016) H. Dorota Halicka et al.   APOPTOSIS

A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT-116 colon cancer cells

(2016) Ashok Kumar et al.   CELL BIOCHEMISTRY AND FUNCTION

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

(2016) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prophylactic role of some plants and phytochemicals against radio-genotoxicity in human lymphocytes

(2016) Alireza Shirazi et al.   Journal of Cancer Research and Therapeutics

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells

(2016) Ming-Ju Hsieh et al.   PHYTOMEDICINE

Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance

(2016) WEI-LIANG SUN   Oncology Letters

SH003 suppresses breast cancer growth by accumulating p62 in autolysosomes

(2016) Youn Kyung Choi et al.   Oncotarget

SH003 represses tumor angiogenesis by blocking VEGF binding to VEGFR2

(2016) Hyeong Sim Choi et al.   Oncotarget

Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90

(2016) Kuei-Hung Lai et al.   Scientific Reports

The Cytotoxic and Mechanistic Effects of Aaptamine on Hepatocellular Carcinoma

(2015) Qiao-lu Li et al.   Anti-Cancer Agents in Medicinal Chemistry

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

(2015) Jeong Yong Jeon et al.   BMC CANCER

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

(2015) Hélène C. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tackling the Cytotoxic Effect of a Marine Polycyclic Quinone-Type Metabolite: Halenaquinone Induces Molt 4 Cells Apoptosis via Oxidative Stress Combined with the Inhibition of HDAC and Topoisomerase Activities

(2015) Shou-Ping Shih et al.   Marine Drugs

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

(2015) Xinbing Sui et al.   MOLECULAR PHARMACEUTICS

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

(2015) In-geun Ryoo et al.   Oncotarget

Anti-photoaging effect of aaptamine in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes

(2014) Min-Ji Kim et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Aaptamine Derivatives with Antifungal and Anti-HIV-1 Activities from the South China Sea Sponge Aaptos aaptos

(2014) Hao-Bing Yu et al.   Marine Drugs

Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)

(2014) Kamini Singh et al.   Molecular Cancer

Sequestosome 1/p62 facilitates HER2-induced mammary tumorigenesis through multiple signaling pathways

(2014) X Cai-McRae et al.   ONCOGENE

Aaptamines from the Marine SpongeAaptossp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mouse JB6 Cl41 Cells

(2014) Sergey A. Dyshlovoy et al.   Biomed Research International

Cancer wars: natural products strike back

(2014) Christine Basmadjian et al.   Frontiers in Chemistry

Cellular and molecular mechanisms in the hypoxic tissue: role of HIF-1 and ROS

(2013) Andrea B. Zepeda et al.   CELL BIOCHEMISTRY AND FUNCTION

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer

(2013) Sergey A. Dyshlovoy et al.   Journal of Proteomics

Towards the Small and the Beautiful: A Small Dibromotyrosine Derivative from Pseudoceratina sp. Sponge Exhibits Potent Apoptotic Effect through Targeting IKK/NFκB Signaling Pathway

(2013) Jui-Hsin Su et al.   Marine Drugs

21st Century natural product research and drug development and traditional medicines

(2013) Linh T. Ngo et al.   NATURAL PRODUCT REPORTS

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation

(2013) X Guo et al.   Cell Death & Disease

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Synthesis of Two Unnatural Oxygenated Aaptaminoids

(2012) Giorgio Abbiati et al.   JOURNAL OF ORGANIC CHEMISTRY

Marine natural products

(2012) John W. Blunt et al.   NATURAL PRODUCT REPORTS

The cytoprotective role of the Keap1–Nrf2 pathway

(2011) Liam Baird et al.   ARCHIVES OF TOXICOLOGY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Reactive oxygen species-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to polydatin-induced apoptosis in human nasopharyngeal carcinoma CNE cells

(2011) Huanhai Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aaptamine, an alkaloid from the sponge Aaptos suberitoides, functions as a proteasome inhibitor

(2010) Sachiko Tsukamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of p62 by cdk1 Controls the Timely Transit of Cells through Mitosis and Tumor Cell Proliferation

(2010) J. F. Linares et al.   MOLECULAR AND CELLULAR BIOLOGY

ErbB receptors and signaling pathways in cancer

(2009) Nancy E Hynes et al.   CURRENT OPINION IN CELL BIOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Antiviral and Anticancer Optimization Studies of the DNA-binding Marine Natural Product Aaptamine

(2008) John J. Bowling et al.   Chemical Biology & Drug Design

Cytotoxic Aaptamines from Malaysian Aaptos aaptos

(2008) Khozirah Shaari et al.   Marine Drugs

Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores

(2007) Jeffrey A. Diers et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR