Article
Food Science & Technology
Zhenzhen Deng, Ning Wu, Jing Wang, Quanbin Zhang
Summary: By extracting dietary fiber DFSJ from Saccharina japonica, significant improvements in insulin resistance and dyslipidemia in high fat diet-induced MetS mice were observed, along with a positive effect on stabilizing gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
Lin Feng, Jie Zhou, Liang Zhang, Panpan Liu, Pengcheng Zheng, Shiwei Gao, Chuankui Song, Yongchao Yu, Ziming Gong, Xiaochun Wan
Summary: The study found that QZT extract can significantly prevent weight gain and fat accumulation, while also reducing serum levels of total cholesterol and triglycerides. This is accompanied by changes in the Firmicutes-to-Bacteroidetes ratio and the relative abundance of S24-7 and Ruminococcaceae in the gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Priscila dos Santos Gomes Olivares, Ana Beatriz Furlanetto Pacheco, Luciana Nicolau Aranha, Bianca da Silva Oliveira, Allan Amorim Santos, Paula Cristina Moreira dos Santos, Jose Firmino Nogueira Neto, Glorimar Rosa, Glaucia Maria Moraes Oliveira
Summary: This study investigated the gut microbiota of individuals with different metabolic phenotypes and found that metabolically healthy individuals had lower saturated fat intake and fasting glycemia. Those with unhealthy phenotypes had inflammation-associated microbiota, lower potential for butyrate production, and reduced bacterial diversity.
Article
Food Science & Technology
Ju Kyoung Oh, Robie Vasquez, Sang Hoon Kim, Je Hyeon Lee, Eun Joo Kim, Soon-Kwang Hong, Dae-Kyung Kang
Summary: The study showed that supplementation of neoagarooligosaccharides (NAOs) in obese rats can reduce body weight, improve metabolism, and modulate the gut microbiome by enriching bacteria negatively associated with obesity. This suggests that the anti-obesity effect of NAOs may be linked to their regulatory effect on gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Siqi Li, Mengqian Wang, Chang Li, Qingjia Meng, Yantong Meng, Jian Ying, Shuqun Bai, Qun Shen, Yong Xue
Summary: This study found that partly milled highland barley (PHB) can regulate the serum glucose and lipid disorders of mice fed a high-fat diet (HFD) and has the potential to modulate gut microbiota. PHB supplementation reduced fasting blood glucose and improved oral glucose tolerance. PHB also prevented HFD-induced gut microbiota dysbiosis, enriching beneficial bacteria and reducing HFD-dependent taxa.
Review
Food Science & Technology
Martina De Siena, Pauline Raoul, Lara Costantini, Emidio Scarpellini, Marco Cintoni, Antonio Gasbarrini, Emanuele Rinninella, Maria Cristina Mele
Summary: The use of emulsifiers in processed foods and the increasing prevalence of metabolic syndrome in Western countries have sparked interest in understanding their potential impact on gut microbiota and metabolic disorders. This review provides a summary of the current clinical evidence on the effects of emulsifiers on gut microbiota composition and functions, highlighting the presence and role of common emulsifiers in daily foods. Recent studies on the impact of different emulsifiers on gut microbiota have shed light on their potential contribution to metabolic diseases, as well as their prebiotic effects. However, further research is needed to uncover the optimal consumption amounts and individual microbial responses to emulsifier intake.
Article
Plant Sciences
Man Chen, Junping Zheng, Xiaojuan Zou, Cheng Ye, Hui Xia, Ming Yang, Qinghua Gao, Qingxiong Yang, Hongtao Liu
Summary: LRE, mainly composed of ligupurpuroside A and aceteoside, alleviated insulin resistance and improved hepatic metabolism in HFD-fed mice. It also reshaped the gut microbiota structure by increasing the levels of genera Streptococcus, Lactobacillus, and Mucispirillum while decreasing the populations of Alistipes and Lachnospiraceae NK4A136 group in HFD-fed mice. The altered gut microbiota was associated with several metabolic pathways of gut bacteria, indicating the potential of LRE as a gut microbial regulator for preventing metabolic syndrome.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Briana K. Clifford, Nadia M. L. Amorim, Nadeem O. Kaakoush, Lykke Boysen, Nicodemus Tedla, David Goldstein, Edna C. Hardeman, David Simar
Summary: This study aimed to investigate the effects of irradiation and diet on the gut microbiota and metabolic or immune functions. The results showed a compounding negative impact of irradiation and a high-fat diet on the metabolic and immune profiles of adipose tissue, along with altered microbiota. These findings are important for the diagnosis and prevention of metabolic complications in cancer survivors exposed to radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yang Lin, Zi-Yuan Wang, Ma-Jie Wang, Zheng-Meng Jiang, Ya-Qiu Qin, Tian-Qing Huang, Yu Song, Hui-Ting Liang, E-Hu Liu
Summary: This study examined the effects of baicalin (BC) on high-fat diet-induced metabolic syndrome (MetS) in mice and its impact on gut microbiota composition. The results showed that BC could reduce body weight gain, hepatic fat accumulation, and abnormal blood lipids, and increase insulin sensitivity. BC also reversed the alteration of metabolites induced by high-fat diet and affected metabolic pathways. The analysis of gut microbiota demonstrated that BC altered the composition and function of gut microbiota in MetS mice. The study suggests that BC may be a potential therapeutic drug for improving MetS and the gut microbiome could be a novel mechanistic target for BC treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Food Science & Technology
Fang Zhou, Ming-zhi Zhu, Jing-yi Tang, Jian Ou-Yang, Bo-hao Shang, Chang-wei Liu, Jiang Wang, Qi Liu, Jian-an Huang, Zhong-hua Liu
Summary: This study investigates the effects of six types of tea extracts on metabolic syndrome and compares their chemical components. It is found that all six tea extracts attenuate metabolic syndrome and improve intestinal barrier function. Among them, white tea performs better in body weight control, while dark tea has more advantages in protecting intestinal barrier. Moreover, all six tea extracts also alleviate gut microbiota dysbiosis.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Tingwei Wang, Yongli Ye, Jian Ji, Shuang Zhang, Xingxing Yang, Jiayuan Xu, Jia-Sheng Wang, Zhiyuan Chen, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun
Summary: Astilbin consumption has significant anti-obesity and anti-inflammatory effects in high-fat diet mice. It improves gut microbial dysbiosis, enhances intestinal carbohydrate and lipid metabolism, and protects the integrity of the intestinal barrier. Astilbin is a potential prebiotic for the prevention of gut-liver axis damage and metabolic disruption in obese individuals.
Article
Microbiology
Jinjin Li, Jialin Li, Jiajia Ni, Caibo Zhang, Jianlei Jia, Guoying Wu, Hongzhao Sun, Shuzhen Wang
Summary: Berberine regulates the gut microbiota structure and expression of inflammatory factors, improving high-fat diet-induced inflammatory metabolic syndrome and effectively improving metabolism of high-fat foods in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Lingyun Lu, Mengjia Tang, Jiao Li, Ying Xie, Yujue Li, Jinwei Xie, Li Zhou, Yi Liu, Xijie Yu
Summary: This study identified the potential mechanisms of HFD-induced bone loss, revealing the associations between alterations in GM and serum metabolites with bone loss. These findings provide new insights into understanding HFD-related osteoporosis and suggest the need for further exploration of the regulatory effects of GM and metabolites on bone homeostasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiaozhong Huang, Qingguo Cao, Cen Chen, Zhenglin Xie, Jinshan Fan
Summary: This study investigates the effects of fermented barley extracts on obesity and inflammatory responses, and suggests that these extracts could be beneficial in improving inflammatory status and gut microflora.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Review
Chemistry, Applied
Santosh Kumar Bose, Prianka Howlader, Wenxia Wang, Heng Yin
Summary: The lack of proper postharvest management of fruits leads to economic losses, poverty, hunger, and malnutrition. To address postharvest losses, various technologies and chemical treatments are used globally, but some may pose risks to human health and the environment. Recently, oligosaccharides have gained attention for their health benefits and potential applications in agriculture, showing promising results in improving postharvest preservation of fruits by maintaining antioxidant activity and delaying cell wall degradation through hormone regulation. This review provides insights into the preservation effects of different oligosaccharides on fruits and offers future research directions for enhancing postharvest preservation.
Article
Biotechnology & Applied Microbiology
Kuikui Li, Chaofeng Jiang, Haidong Tan, Junyan Li, Yali Xu, Dejian Tang, Xiaoming Zhao, Qishun Liu, Jianguo Li, Heng Yin
Summary: The glucomannanase PpGluB shows high specificity for degrading konjac glucomannan, producing oligosaccharides with degrees of polymerisation of 2-12. It exhibits optimal activity at 45-55 degrees C and pH 5.0-6.0, as well as high pH stability over a broad pH range.
Article
Clinical Neurology
Baifei Hu, Xuefen Zhu, Junping Zheng, Yanlei Guo, Haiming Hu, Xiaojuan Zou, Xiaowei Yao, Zhanli Liu, Hongtao Liu
Summary: This study explores the relationship between serum metabolites, gut microbiota, and febrile seizures (FS) using metabolomics and 16S rDNA sequencing. The results reveal abnormalities in serum metabolic pathways in FS patients and a significant reduction in gut microbiota diversity. By detecting serum metabolites and gut microbiota, new methods for FS diagnosis and classification of seizure types can be provided.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Plant Sciences
Ruixin Li, Maolong Li, Jinxia He, Hongguo Xie, Wenxia Wang, Meng Zhang, Gustavo Cabrera-Barjas, Pierfrancesco Morganti, Heng Yin
Summary: The study found that pectin nanospheres have a promoting effect on wheat germination and seedling growth, increasing seed germination rate and net photosynthetic rate, and facilitating nutrient uptake in plants.
JOURNAL OF PLANT GROWTH REGULATION
(2022)
Article
Chemistry, Analytical
Yu Liu, Yanan Cao, Cong Zhang, Cheng Ye, Qinglai Bian, Xue Cheng, Hui Xia, Junping Zheng, Hongtao Liu
Summary: This study proposes a novel colorimetric method using gold nanoparticles (AuNPs) for the rapid and visual detection of hydrogen peroxide (H2O2) and oxidase-specific substrates. The method demonstrates high specificity, high sensitivity, and tolerance to the influence of dissolved oxygen.
ANALYTICA CHIMICA ACTA
(2022)
Article
Food Science & Technology
Yanan Cao, Cheng Ye, Cong Zhang, Guohao Zhang, Haiming Hu, Zhigang Zhang, Haitian Fang, Junping Zheng, Hongtao Liu
Summary: The integration of LAMP onto a microfluidic chip improves the simplicity and portability of food safety control, with successful rapid detection of multiple pathogens. The technology shows high specificity and sensitivity, enabling simultaneous detection of four pathogens in a short time, making it a potential tool for on-site monitoring of foodborne pathogens.
Article
Chemistry, Analytical
Xiaoyu Zhang, Baifei Hu, Guangjun Sun, Junping Zheng, Haiming Hu, Huabing Yang, Xue Cheng, Aizhen Lin, Hongtao Liu
Summary: Chitosan oligosaccharides (COS) were found to reverse the abnormal changes in sphingolipid, glycerophospholipid, tryptophan, bile acids, unsaturated fatty acids, and amino acids metabolism induced by loperamide in constipated mice. Additionally, COS treatment suppressed the abnormal expression of key genes related to these metabolic pathways in the colon samples. This study provides insight into the mechanisms by which COS ameliorates loperamide-induced constipation in mice.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Physical
Yijie Dong, Tang Li, Shiqing Zhang, Joaquin Sanchis, Heng Yin, Jie Ren, Xiang Sheng, Guangyue Li, Manfred T. Reetz
Summary: In this study, the unexpected mechanistic intricacies of Baeyer-Villiger monooxygenases (BVMOs) were discovered, providing insights for expanding their applications in synthetic organic chemistry and biotechnology. The investigation utilized complete mutational deconvolution and experimental construction of a fitness-pathway landscape to elucidate the structural changes of Criegee intermediates and their effects on the evolutionary process.
Article
Biochemistry & Molecular Biology
Ling Huang, Junping Zheng, Guangjun Sun, Huabing Yang, Xiongjie Sun, Xiaowei Yao, Aizhen Lin, Hongtao Liu
Summary: It has been found that 5-aminosalicylic acid (5-ASA) can improve colitis symptoms by modulating gut microbiota and bile acid metabolism. In a mouse model, treatment with 5-ASA alleviated colitis symptoms, increased body weight and colon length, and reduced disease activity index and spleen index. Moreover, 5-ASA protected colonic tissues by suppressing inflammation and decreasing levels of tight junction, mucin, and water-sodium transport proteins, and it reshaped the gut microbiota community structure by promoting beneficial bacteria and reducing harmful bacteria. Additionally, 5-ASA improved abnormal bile acid metabolism through specific signaling pathways. However, the protective effect of 5-ASA was only observed in mice with normal gut microbiota, emphasizing the importance of gut microbiota in colitis treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Plant Sciences
Kuikui Li, Chunlai Zhang, Wenxia Wang, Changzheng Chen, Qishun Liu, Heng Yin
Article
Chemistry, Analytical
Lilin Song, Mengru Sun, Jinhui Shi, Zhenhao Tian, Yuqing Song, Huixin Liu, Shanshan Zhao, Heng Yin, Guangbo Ge
Summary: By using computer-aided molecular design and experimental verification, octanoyl luciferin (OL) was selected as a reliable bioluminescent substrate for detecting Notum activity in complex biological systems. OL showed excellent specificity, high detection sensitivity, and high signal-to-noise ratio for human Notum. This study provides a reliable and easy-to-use tool for sensing Notum activities in biological systems, which will strongly facilitate fundamental studies, disease diagnosis, and drug discovery related to Notum.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Zhongbin Xiao, Kuikui Li, Tang Li, Fanxing Zhang, Jiayi Xue, Miao Zhao, Heng Yin
Summary: Alginate lyase VwAlg7A, a novel PL7 family exolytic alginate lyase, was successfully heterologously expressed in E. coli BL21 (DE3). VwAlg7A showed specificity towards poly-guluronate and exhibited optimal temperature and pH at 30 degrees C and 7.0, respectively. The activity of VwAlg7A could be inhibited by Ni2+, Zn2+, and NaCl, and its kinetic parameters were determined as K-m of 36.9 mg/ml and V-max of 395.6 mu M/min. ESI and HPAEC-PAD results confirmed the exolytic mode of sugar bond cleavage by VwAlg7A, and important catalytic residues were identified through molecular docking and mutagenesis experiments.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Xiaochen Jia, Hongyan Zhang, Hongqiang Qin, Kuikui Li, Xiaoyan Liu, Wenxia Wang, Mingliang Ye, Heng Yin
Summary: In this study, a functional plant AGM (AtAGM) was identified from Arabidopsis thaliana, with a significant role in UDP-GlcNAc biosynthesis pathway. AtAGM catalyzes the isomerization of GlcNAc-1-P and GlcNAc-6-P, and has broad catalytic activity on different phosphohexoses. The decrease in UDP-GlcNAc content in AtAGM mutants resulted in impaired protein O-GlcNAcylation and temperature-dependent growth defects in seedlings.
Article
Plant Sciences
Yu Wang, Peiyu Xu, Wenxia Wang, Xiaochen Jia, Liping Zhu, Heng Yin
Summary: Chitosan oligosaccharides (COS) and alginate oligosaccharides (AOS) promote the growth and biosynthesis of steviol glycosides (SGs) in stevia. They increase plant biomass by improving photosynthetic efficiency and leaf number, reducing abscisic acid content, and enhancing the expression of SGs biosynthesis-related genes. Moreover, COS and AOS increase the contents of sweet compounds such as stevioside and rebaudioside A in stevia. In addition, they induce geometric changes in stevia stems, thereby increasing its lodging resistance.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lin Zhu, Guangming Chen, Yanlei Guo, Junping Zheng, Huabing Yang, Xiongjie Sun, Yang Liu, Baifei Hu, Hongtao Liu
Summary: In this study, novel Poria cocos oligosaccharides (PCO) were prepared by enzymatic degradation and found to have a polymerization degree of 2-6. PCO showed significant suppression of lipid metabolism disorders in a mouse model with dyslipidemia. Metabolomic analysis indicated that PCO may reverse the altered metabolic pathways related to glycerophospholipids, unsaturated fatty acids, amino acids, choline, bile acids, tryptophan, sphingolipids, and glutathione. These findings highlight the potential use of PCO for treating dyslipidemia.
