期刊
TRENDS IN IMMUNOLOGY
卷 34, 期 3, 页码 107-113出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2012.11.003
关键词
regulatory T cells; bone marrow transplantation; solid organ transplantation
类别
资金
- Wellcome Trust
- Medical Research Council UK
- British Heart Foundation
- European Union
- Royal College of Surgeons of England
- Oxford Health Services Research Committee Charitable Trust
- Restore Burn and Wound Research Trust
- MRC [G0800842] Funding Source: UKRI
- British Heart Foundation [FS/12/72/29754] Funding Source: researchfish
- Medical Research Council [G0800842] Funding Source: researchfish
Multiple cell types contribute to the peripheral regulation of T cell alloresponses in haematopoieitc cell transplantation (HCT) and solid organ transplantation (SOT). Of these, regulatory T cells (Tregs) are the principal players and have shown the greatest success in the therapeutic control of detrimental immune responses. Investigations into the induction, location, and mechanism of suppression utilised by Tregs to control alloreactive responses are ongoing. The activation and homing characteristics of Tregs are important to their regulatory capabilities, with activation and homing occurring in the same time and space as conventional T cells. This review discusses these characteristics and recent advances in the field as we move closer to the ultimate goal of utilising Tregs as treatment for allograft rejection and graft-versus-host disease (GvHD).
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