BAG3: a new player in the heart failure paradigm

BAG3 facilitates the clearance of endogenous tau in primary neurons

(2015) Zhinian Lei et al.   NEUROBIOLOGY OF AGING

The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth

(2015) Gennaro Chiappetta et al.   Oncotarget

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

Activation of the MAPK11/12/13/14 (p38 MAPK) pathway regulates the transcription of autophagy genes in response to oxidative stress induced by a novel copper complex in HeLa cells

(2014) Wu Zhong et al.   Autophagy

Hsp70–Bag3 Interactions Regulate Cancer-Related Signaling Networks

(2014) Teresa A. Colvin et al.   CANCER RESEARCH

HIV-1 Tat protein induces glial cell autophagy through enhancement of BAG3 protein levels

(2014) Anna Paola Bruno et al.   CELL CYCLE

β-Adrenergic Receptor–Mediated Cardiac Contractility Is Inhibited via Vasopressin Type 1A-Receptor–Dependent Signaling

(2014) Douglas G. Tilley et al.   CIRCULATION

BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer

(2014) Asuka Sugio et al.   GYNECOLOGIC ONCOLOGY

Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy

(2014) Arthur M. Feldman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

WW Domain of BAG3 Is Required for the Induction of Autophagy in Glioma Cells

(2014) Nana Merabova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diagnosis of muscle diseases presenting with early respiratory failure

(2014) Gerald Pfeffer et al.   JOURNAL OF NEUROLOGY

Knockdown of BAG3 induces epithelial–mesenchymal transition in thyroid cancer cells through ZEB1 activation

(2014) X Meng et al.   Cell Death & Disease

BAG3 Protein in Advanced-Stage Heart Failure

(2014) Margot De Marco et al.   JACC-Heart Failure

Tension-induced autophagy

(2013) Anna Ulbricht et al.   Autophagy

BAG3-dependent noncanonical autophagy induced by proteasome inhibition in HepG2 cells

(2013) Bao-Qin Liu et al.   Autophagy

BAG3 is upregulated by c-Jun and stabilizes JunD

(2013) Chao Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prognostic Significance of Biomarkers in Predicting Outcome in Patients With Coronary Artery Disease and Left Ventricular Dysfunction

(2013) Arthur M. Feldman et al.   Circulation-Heart Failure

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

Polymorphisms of the antiapoptotic protein bag3 may play a role in the pathogenesis of tako-tsubo cardiomyopathy

(2013) Rodolfo Citro et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

BAG3 regulates epithelial–mesenchymal transition and angiogenesis in human hepatocellular carcinoma

(2013) Heng Xiao et al.   LABORATORY INVESTIGATION

Functions and mechanics of dynein motor proteins

(2013) Anthony J. Roberts et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detection of soluble BAG3 and anti-BAG3 antibodies in patients with chronic heart failure

(2013) M De Marco et al.   Cell Death & Disease

Expression of the Antiapoptotic Protein BAG3 Is a Feature of Pancreatic Adenocarcinoma and Its Overexpression Is Associated With Poorer Survival

(2012) Alessandra Rosati et al.   AMERICAN JOURNAL OF PATHOLOGY

NF- B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex

(2012) M. Nivon et al.   JOURNAL OF CELL SCIENCE

BAG3 controls angiogenesis through regulation of ERK phosphorylation

(2012) A Falco et al.   ONCOGENE

PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial−mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells

(2012) N Li et al.   ONCOGENE

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

BAG3 Protein Is Overexpressed in Human Glioblastoma and Is a Potential Target for Therapy

(2011) Michelina Festa et al.   AMERICAN JOURNAL OF PATHOLOGY

BAG3-related myofibrillar myopathy in a Chinese family

(2011) HC Lee et al.   CLINICAL GENETICS

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Involvement of JNK and NF-κB pathways in lipopolysaccharide (LPS)-induced BAG3 expression in human monocytic cells

(2011) Hua-Qin Wang et al.   EXPERIMENTAL CELL RESEARCH

Dilated cardiomyopathy-associatedBAG3mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

(2011) Takuro Arimura et al.   HUMAN MUTATION

Expression of the Anti-Apoptotic Protein BAG3 in Human Melanomas

(2011) Renato Franco et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins

(2011) Martin Gamerdinger et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

(2011) K. Seidel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

BAG3 Directly Interacts with Mutated alphaB-Crystallin to Suppress Its Aggregation and Toxicity

(2011) Akinori Hishiya et al.   PLoS One

BAG3: a multifaceted protein that regulates major cell pathways

(2011) A Rosati et al.   Cell Death & Disease

Down-modulation of Bis sensitizes cell death in C6 glioma cells induced by oxygen–glucose deprivation

(2010) Seung Eun Jung et al.   BRAIN RESEARCH

BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

(2010) Akinori Hishiya et al.   CIRCULATION RESEARCH

Manipulation of Death Pathways in Desmin-Related Cardiomyopathy

(2010) Alina Maloyan et al.   CIRCULATION RESEARCH

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

Nebulin regulates actin filament lengths by a stabilization mechanism

(2010) Christopher T. Pappas et al.   JOURNAL OF CELL BIOLOGY

WT1 protein is a transcriptional activator of the antiapoptotic bag3 gene

(2010) E Cesaro et al.   LEUKEMIA

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

(2010) Zagaa Odgerel et al.   NEUROMUSCULAR DISORDERS

IKK  protein is a target of BAG3 regulatory activity in human tumor growth

(2010) M. Ammirante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caught in the middle: the role of Bag3 in disease: Figure 1

(2009) Andrea K. McCollum et al.   BIOCHEMICAL JOURNAL

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

(2009) Margit Fuchs et al.   BIOCHEMICAL JOURNAL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Autoregulation of co-chaperone BAG3 gene transcription

(2009) Antonio Gentilella et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Caspase-dependent cleavage of BAG3 in proteasome inhibitors-induced apoptosis in thyroid cancer cells

(2008) Zhen-Xian Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Acute Effects of Haemodialysis on Pro-/Anti- Apoptotic Genes in Peripheral Blood Leukocytes

(2008) Björn Friedrich et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

bag3 gene expression is regulated by heat shock factor 1

(2008) Silvia Franceschelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nebulin Interacts with CapZ and Regulates Thin Filament Architecture within the Z-Disc

(2008) Christopher T. Pappas et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of BAG3 by Egr-1 in response to FGF-2 in neuroblastoma cells

(2008) A Gentilella et al.   ONCOGENE

Transcriptional upregulation of BAG3 upon proteasome inhibition

(2007) Hua-Qin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS