Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2 tm1.1Bird Mouse, a Model for Rett Syndrome

Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice

(2017) Mahalakshmi Shankaran et al.   NEUROBIOLOGY OF DISEASE

Development of a Novel AAV Gene Therapy Cassette with Improved Safety Features and Efficacy in a Mouse Model of Rett Syndrome

(2017) Kamal K.E. Gadalla et al.   Molecular Therapy-Methods & Clinical Development

Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels

(2017) Paula J. Jansen et al.   JOURNAL OF ALZHEIMERS DISEASE

Characterization of Rett Syndrome-like phenotypes in Mecp2-knockout rats

(2016) Yang Wu et al.   Journal of Neurodevelopmental Disorders

LXR Regulation of Brain Cholesterol: From Development to Disease

(2016) Rebecca Courtney et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lovastatin fails to improve motor performance and survival in methyl-CpG-binding protein2-null mice

(2016) Claudia Villani et al.   eLife

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

(2016) Maria Fiorentino et al.   Molecular Autism

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MECP2 disorders: from the clinic to mice and back

(2015) Laura Marie Lombardi et al.   JOURNAL OF CLINICAL INVESTIGATION

Rett syndrome: a complex disorder with simple roots

(2015) Matthew J. Lyst et al.   NATURE REVIEWS GENETICS

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome

(2014) Claudio De Felice et al.   NEUROBIOLOGY OF DISEASE

Cholesterol Metabolism Is Altered in Rett Syndrome: A Study on Plasma and Primary Cultured Fibroblasts Derived from Patients

(2014) Marco Segatto et al.   PLoS One

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic andCyp27a1−/−mice

(2013) Zeina Ali et al.   JOURNAL OF LIPID RESEARCH

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier

(2013) Ahmed Saeed et al.   JOURNAL OF LIPID RESEARCH

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

(2013) Christie M Buchovecky et al.   NATURE GENETICS

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

(2013) Ryo Suzuki et al.   PLOS BIOLOGY

Cholesterol homeostasis: a key to prevent or slow down neurodegeneration

(2013) Laura Anchisi et al.   Frontiers in Physiology

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

(2012) J. E. Vance   Disease Models & Mechanisms

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

(2012) Anna Meljon et al.   JOURNAL OF LIPID RESEARCH

Dietary intake of plant sterols stably increases plant sterol levels in the murine brain

(2012) Tim Vanmierlo et al.   JOURNAL OF LIPID RESEARCH

MeCP2 Is Critical for Maintaining Mature Neuronal Networks and Global Brain Anatomy during Late Stages of Postnatal Brain Development and in the Mature Adult Brain

(2012) M. V. C. Nguyen et al.   JOURNAL OF NEUROSCIENCE

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

(2011) A. Aqul et al.   JOURNAL OF NEUROSCIENCE

Alterations of cholesterol precursor levels in Alzheimer's disease

(2010) Heike Kölsch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol Oxidation Products Are Sensitive and Specific Blood-Based Biomarkers for Niemann-Pick C1 Disease

(2010) F. D. Porter et al.   Science Translational Medicine

Mouse models of MeCP2 disorders share gene expression changes in the cerebellum and hypothalamus

(2009) Shay Ben-Shachar et al.   HUMAN MOLECULAR GENETICS

Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

(2009) Benny Liu et al.   JOURNAL OF LIPID RESEARCH

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease

(2008) Valerio Leoni et al.   BRAIN

Comparative study of brain morphology inMecp2mutant mouse models of Rett syndrome

(2008) Nadia P. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Brain Lipid Analysis in Mice with Rett Syndrome

(2008) Thomas N. Seyfried et al.   NEUROCHEMICAL RESEARCH