Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

(2018) Gannie Tzoneva et al.   NATURE

ETV6/RUNX1 -like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype

(2017) Marketa Zaliova et al.   GENES CHROMOSOMES & CANCER

Mutational profiling of acute lymphoblastic leukemia with testicular relapse

(2017) Ling-Wen Ding et al.   Journal of Hematology & Oncology

Arpeggio: A Web Server for Calculating and Visualising Interatomic Interactions in Protein Structures

(2017) Harry C Jubb et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia

(2017) P Richter-Pechańska et al.   Blood Cancer Journal

The cytosolic 5’-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells

(2017) Gabriel Bricard et al.   Oncotarget

Distinct bilineal leukemia immunophenotypes are not genetically determined

(2016) M. Kotrova et al.   BLOOD

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia

(2016) Aleš Hnízda et al.   BMC BIOLOGY

Single-particle cryo-electron microscopy

(2016) Allison Doerr   NATURE METHODS

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

Identification of Noncompetitive Inhibitors of Cytosolic 5′-Nucleotidase II Using a Fragment-Based Approach

(2015) Zsuzsanna Marton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating

(2015) Rosanna P. Baker et al.   NATURE

Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

(2015) Benshang Li et al.   NATURE MEDICINE

Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation

(2015) J. B. Kunz et al.   HAEMATOLOGICA

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Resistance revealed in acute lymphoblastic leukemia

(2013) Jon C. Aster et al.   NATURE MEDICINE

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

Structural Model of Lymphocyte Receptor NKR-P1C Revealed by Mass Spectrometry and Molecular Modeling

(2012) Daniel Rozbesky et al.   ANALYTICAL CHEMISTRY

Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin

(2012) Uwe Mueller et al.   JOURNAL OF SYNCHROTRON RADIATION

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II

(2011) Karin Walldén et al.   JOURNAL OF MOLECULAR BIOLOGY

Biochemical and structural analysis of 14 mutant adsl enzyme complexes and correlation to phenotypic heterogeneity of adenylosuccinate lyase deficiency

(2010) Marie Zikanova et al.   HUMAN MUTATION

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

The Role of Oligomerization and Cooperative Regulation in Protein Function: The Case of Tryptophan Synthase

(2010) M. Qaiser Fatmi et al.   PLoS Computational Biology