Maximizing the impact of microphysiological systems with in vitro–in vivo translation

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

(2017) Christian Maass et al.   Integrative Biology

A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties

(2017) A. M. Clark et al.   LAB ON A CHIP

Tissue chips – innovative tools for drug development and disease modeling

(2017) L. A. Low et al.   LAB ON A CHIP

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

(2017) Tomasz Kostrzewski et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Organ-On-A-Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies

(2017) Samad Ahadian et al.   Advanced Healthcare Materials

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

(2017) Tongcheng Qian et al.   Science Advances

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Physiologically based pharmacokinetic modeling in regulatory decision-making at the European Medicines Agency

(2016) E Luzon et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Idiosyncratic Drug-Induced Liver Injury: Is Drug-Cytokine Interaction the Linchpin?

(2016) Robert A. Roth et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Development of a microphysiological model of human kidney proximal tubule function

(2016) Elijah J. Weber et al.   KIDNEY INTERNATIONAL

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Facilitating the commercialization and use of organ platforms generated by the microphysiological systems (Tissue Chip) program through public–private partnerships

(2016) Christine A. Livingston et al.   Computational and Structural Biotechnology Journal

The promises of quantitative systems pharmacology modelling for drug development

(2016) V.R. Knight-Schrijver et al.   Computational and Structural Biotechnology Journal

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

(2015) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

(2015) HM Jones et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system

(2014) S E Wheeler et al.   BRITISH JOURNAL OF CANCER

Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

(2014) Christian Wagner et al.   CLINICAL PHARMACOKINETICS

The Posology of Oseltamivir in Infants With Influenza Infection Using a Population Pharmacokinetic Approach

(2014) M A Kamal et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Using physiologically-based pharmacokinetic-guided “body-on-a-chip” systems to predict mammalian response to drug and chemical exposure

(2014) Jong Hwan Sung et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Quantitative Systems Pharmacology can reduce attrition and improve productivity in pharmaceutical research and development

(2014) Tarek A. Leil et al.   Frontiers in Pharmacology

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

(2014) Jeffrey L. Woodhead et al.   Frontiers in Pharmacology

The Utility of Modeling and Simulation in Drug Development and Regulatory Review

(2013) Shiew-Mei Huang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

(2013) Jong H. Sung et al.   LAB ON A CHIP

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

(2011) Neil Parrott et al.   CLINICAL PHARMACOKINETICS

Disease–Drug–Drug Interaction Involving Tocilizumab and Simvastatin in Patients With Rheumatoid Arthritis

(2011) C Schmitt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development

(2011) Piet H. van der Graaf et al.   PHARMACEUTICAL RESEARCH

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity

(2010) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

A novel system for evaluation of drug mixtures for potential efficacy in treating multidrug resistant cancers

(2008) Daniel A. Tatosian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS