Article
Urology & Nephrology
Kyongtae T. Bae, Cheng Tao, Robert Feldman, Alan S. L. Yu, Vicente E. Torres, Ronald D. Perrone, Arlene B. Chapman, Godela Brosnahan, Theodore I. Steinman, William E. Braun, Michal Mrug, William M. Bennett, Peter C. Harris, Avantika Srivastava, Douglas P. Landsittel, Kaleab Z. Abebe
Summary: This study aimed to evaluate the associations of polycystic liver progression with other disease progression variables and classify liver progression on the basis of patient's age, height-adjusted liver cystic volume, and height-adjusted liver volume. The use of height-adjusted liver cystic volume showed greater separations in volumetric progression of polycystic liver disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Katharina Hopp, Victoria A. Catenacci, Nidhi Dwivedi, Timothy L. Kline, Wei Wang, Zhiying You, Dustin T. Nguyen, Kristen Bing, Bhavya Poudyal, Ginger C. Johnson, Matthew R. Jackman, Marsha Miller, Cortney N. Steele, Natalie J. Serkova, Paul S. MacLean, Raphael A. Nemenoff, Berenice Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: This study demonstrates that both daily caloric restriction (DCR) and intermittent fasting (IMF) can lead to significant weight loss and slow cyst growth in ADPKD patients. DCR has better efficacy in weight loss compared to IMF, and patients showed higher adherence and tolerability to DCR.
Review
Nutrition & Dietetics
Borja Quiroga, Roser Torra
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited kidney disease, with tolvaptan as the only approved treatment. Dietary modifications, along with other strategies, can help mitigate the adverse effects of tolvaptan and slow disease progression.
Review
Pediatrics
Eric G. Benz, Erum A. Hartung
Summary: ADPKD and ARPKD are characterized by bilateral cystic kidney disease with distinct liver manifestations. The clinical presentation and severity of both diseases are wider than previously recognized, and pediatric and adult nephrologists may care for individuals with these diseases in their lifetimes. Genetic, clinical, and imaging predictors can help forecast disease progression, and pharmacologic therapies are available to prevent progression.
PEDIATRIC NEPHROLOGY
(2021)
Article
Cell Biology
Ismail Kocyigit, Serpil Taheri, Cihan Uysal, Mehmet Memis, Salih Guntug Ozayturk, Gokmen Zararsiz, Minoo Rassoulzadegan
Summary: The study aims to find markers for the development of Autosomal Dominant Polycystic Kidney Disease (ADPKD) to track the disease's epigenetic changes. The study found that the length of telomeres was shortened and the expression levels of TERRA increased in ADPKD patients with PKD1 and PKD2 mutations compared to controls. Furthermore, ADPKD patients with rapid disease progression had higher expression levels of TERRA engaged in the R-loop and shorter telomeres.
Article
Medicine, General & Internal
Anish Raj, Fabian Tollens, Laura Hansen, Alena-Kathrin Golla, Lothar R. Schad, Dominik Noerenberg, Frank G. Zoellner
Summary: This study aims to improve TKV estimation based on U-Net by incorporating attention mechanisms, cosine loss function, and sharpness aware minimization technique, enhancing the accuracy of kidney segmentation. Experimental results demonstrate significant performance improvements using these methods with only 100 MRI datasets.
Review
Nutrition & Dietetics
Lauren Pickel, Ioan-Andrei Iliuta, James Scholey, York Pei, Hoon-Ki Sung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive growth of renal cysts and loss of functional nephrons. Evidence suggests that dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diets have the potential to slow disease progression and confer metabolic benefits.
ADVANCES IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Guangying Shao, Shuai Zhu, Baoxue Yang
Summary: ADPKD is a common hereditary kidney disease characterized by progressively enlarged cysts that destroy renal function, potentially leading to ESRD. Herbal medicines have shown potential in inhibiting cyst development and ADPKD progression, providing new insights for clinical therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Javier Naranjo, Monica Furlano, Ferran Torres, Jonathan Hernandez, Marc Pybus, Laia Ejarque, Christian Cordoba, Lluis Guirado, Elisabet Ars, Roser Torra
Summary: This study compares different predictive tools in ADPKD and finds that MC by ultrasonography could be a viable option, especially in hospitals with limited access to MRI. Integrating different tools to determine RP should facilitate the identification of rapid progressors among patients with ADPKD.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Adrian Cordido, Laura Nunez-Gonzalez, Julio M. Martinez-Moreno, Olaya Lamas-Gonzalez, Laura Rodriguez-Osorio, Maria Vanessa Perez-Gomez, Diego Martin-Sanchez, Patricia Outeda, Marco Chiaravalli, Terry Watnick, Alessandra Boletta, Candido Diaz, Angel Carracedo, Ana B. Sanz, Alberto Ortiz, Miguel A. Garcia-Gonzalez
Summary: The TWEAK signaling pathway plays a crucial role in cystogenesis and cystic growth in ADPKD. High levels of TWEAK and Fn14 were observed in cysts from mouse ADPKD models and in urine/cystic fluid from ADPKD patients. Administration of TWEAK induced cystogenesis and worsened the phenotype, while anti-TWEAK antibodies slowed disease progression and improved outcomes.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Jin Liu, Xiaorui Yin, Hreedi Dev, Xianfu Luo, Jon D. D. Blumenfeld, Hanna Rennert, Martin R. R. Prince
Summary: This study investigates the association between autosomal dominant polycystic kidney disease (ADPKD) and pleural effusion. Pleural effusions were observed in 21% of ADPKD subjects compared to 8% in controls. In a subpopulation controlling for renal function, 25% of ADPKD subjects had pleural effusions compared to 5% of controls.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Jessica T. T. Camargo, Camilo A. Gonzalez, Lina Herrera, Nancy Yomayusa-Gonzalez, Milciades Ibanez, Ana M. M. Valbuena-Garcia, Lizbeth Acuna-Merchan
Summary: This study investigated the prevalence, geographical location, and ethnic groups of ADPKD patients undergoing dialysis or kidney transplant in Colombia between 2015 and 2019. The prevalence of ADPKD was lower compared to Europe and the US, and further genetic prevalence studies may be needed in some states with higher prevalence.
Article
Medicine, General & Internal
Alexander R. Chang, Bryn S. Moore, Jonathan Z. Luo, Gino Sartori, Brian Fang, Steven Jacobs, Yoosif Abdalla, Mohammed Taher, David J. Carey, William J. Triffo, Gurmukteshwar Singh, Tooraj Mirshahi
Summary: This study reveals substantial genetic and phenotypic variability in autosomal dominant polycystic kidney disease (ADPKD) among patients within a regional health system in the US. In addition to PKD1 and PKD2, LOF variants in IFT140, GANAB, and HNF1B were associated with ADPKD diagnosis. Patients with a family history of ADPKD had a higher yield for genetic determinants of the disease.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Urology & Nephrology
Cheng Xue, Bo Yang, Jing Xu, Chenchen Zhou, Liming Zhang, Xiang Gao, Bing Dai, Shengqiang Yu, Zhiguo Mao, Changlin Mei, Chenggang Xu
Summary: Rituximab (RTX) may be an effective and relatively safe alternative for the treatment of adult frequent-relapsing or steroid-dependent nephrotic syndrome patients. Patients with minimal change disease have a higher complete remission rate with RTX, while those with focal segmental glomerulosclerosis have a lower remission rate and further investigation is needed on long-term adverse events.
CLINICAL KIDNEY JOURNAL
(2021)
Letter
Urology & Nephrology
Cheng Xue, Changlin Mei, Jing Xu, Liming Zhang, Zhiguo Mao
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Hematology
Linxi Huang, Cheng Xue, Sixiu Chen, Shoulian Zhou, Bo Yang, Mengna Ruan, Yixin Qian, Jun Wu, Yuqiang Zhang, Xuezhi Zhao, Changlin Mei, Jing Xu, Zhiguo Mao
Summary: This meta-analysis suggests that blind percutaneous insertion methods show better performance in overall mechanical complications and malposition compared to open surgery. The blind percutaneous group has a higher risk of leakage, while the guided percutaneous group shows similar outcomes to the surgical methods. Percutaneous methods also have a lower infection risk.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Zewei Chen, Jing Xu, Jun Wu, Cheng Xue, Mengna Ruan, Changlin Mei, Zhiguo Mao
Summary: This study investigated the clinical and pathological factors influencing the renal outcomes of different types of CrGN and found that the outcomes at 3 months could partially reflect the outcomes at 5 years. The severity of crescents had an unfavorable effect on renal survival.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Cheng Xue, Congdie Liang, Liming Zhang, Chenchen Zhou, Changlin Mei
Article
Medicine, Research & Experimental
Xiaohua Hu, Cheng Xue, Bibo Wu, Hua Yu, Congdie Liang, Liming Zhang
Summary: This article reports a case of slowly occurring venous rupture after reinsertion of a left internal jugular vein catheter. The patient eventually recovered and underwent regular hemodialysis using an arteriovenous fistula. Left internal jugular vein catheterization should be closely monitored and carefully placed to prevent serious complications.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Medicine, General & Internal
Jing Xu, Cheng Xue, Xiaodong Wang, Lei Zhang, Changlin Mei, Zhiguo Mao
Summary: ADPKD, the most common inherited kidney disease worldwide, is mainly influenced by genes PKD1 and PKD2. Epigenetic modifications, particularly chromatin methylation and histone modifications, play a significant role in the development and progression of ADPKD. More research is needed to better understand and potentially treat the methylation abnormalities in ADPKD.
FRONTIERS IN MEDICINE
(2022)
Letter
Urology & Nephrology
Cheng Xue, Bo Yang, Jing Xu, Zhiguo Mao
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Article
Urology & Nephrology
Linxi Huang, Junjie Hu, Cheng Xue, Jiarong Ding, Zhiyong Guo, Bing Yu
Summary: A meta-analysis showed a significant association between vascular calcification and kidney stone disease, suggesting that individuals with vascular calcification have an increased risk of developing kidney stones.
Letter
Pediatrics
Cheng Xue, Bing Dai
PEDIATRIC NEPHROLOGY
(2023)
Article
Computer Science, Information Systems
Haoyang Cui, Yiyi Ma, Ming Yang, Yang Lu, Mingzi Zhang, Lili Fu, Chicheng Fu, Beilin Su, Chuan He, Cheng Xue, Changlin Mei, Shuwei Song
Summary: Polycystic kidney disease is the most common genetic disease of the kidney, and accurately measuring the total kidney volume is crucial for studying its progression. Currently, the manual outlining of kidney boundaries on radiological images is time-consuming, labor-intensive, and subjective. In this research, a hybrid U-shape segmentation method called HUNet is proposed, which incorporates wavelet pooling, cascade residual, and efficient multi-head self-attention. The method was trained and tested on a polycystic kidney dataset, achieving a high Dice similarity coefficient and a minimal difference in total kidney volume values compared to manual segmentation. This approach enables fast and accurate measurement of total kidney volume.
Article
Hematology
Jing Xu, Cheng Xue, Fangzheng Cui, Jiayi Lv, Yanqing Jie, Lingling Liu, Qianwen Zheng, Haigu Fang, Xiangdong Li, Bing Dai, Jing Chen, Zhiguo Mao
Summary: This study recruited MHD patients with a high risk of SARS-CoV-2 transmission and used 4-hour continuous renal replacement therapy as an alternative method for routine MHD during COVID-19 transitional period.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Urology & Nephrology
Cheng Xue, Chenchen Zhou, Bo Yang, Xiaofei Ye, Jing Xu, Yunhui Lu, Xiaohua Hu, Jia Chen, Xiaoling Luo, Liming Zhang, Changlin Mei, Zhiguo Mao
Summary: A nomogram and online calculator were developed and validated to assess the risk of hyperkalemia within 6 months in patients with advanced CKD. Risk factors included age >75 years, higher CKD stages, previous serum potassium >5.0 mmol/L event within 3 months, and comorbidities such as heart failure, diabetes, or metabolic acidosis. The model showed good performance in both internal and external validation sets.
Review
Oncology
Shu Sun, Zhijia Liu, Changqing Chen, Zhisong Wang, Hailong Jin, Xiaoyun Meng, Bing Dai, Liming Zhang, Chenchen Zhou, Cheng Xue, Xiang Li
Summary: The study suggests that plasma FGF23 levels can effectively predict incident AKI in critically ill patients. FGF23 shows good sensitivity and specificity, making it a valuable biomarker for AKI detection. Comparisons with other biomarkers for AKI require further studies for confirmation.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Urology & Nephrology
Jing Xu, Mengna Ruan, Jun Wu, Linxi Huang, Cheng Xue, Sixiu Chen, Changlin Mei, Zhiguo Mao
Summary: This study highlighted the association between renal outcomes of patients with community-acquired acute kidney injury and clinical and pathological factors, emphasizing the importance of renal biopsy in prognostic prediction.
