TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

CystAnalyser: A new software tool for the automatic detection and quantification of cysts in Polycystic Kidney and Liver Disease, and other cystic disorders

(2020) Adrián Cordido et al.   PLoS Computational Biology

Autosomal dominant polycystic kidney disease

(2019) Emilie Cornec-Le Gall et al.   LANCET

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth inPkd1-Deficient Mice

(2018) Yang Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prevalence Estimates of Polycystic Kidney and Liver Disease by Population Sequencing

(2018) Matthew B. Lanktree et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mcp1 Promotes Macrophage-Dependent Cyst Expansion in Autosomal Dominant Polycystic Kidney Disease

(2018) Marcelo F. Cassini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

(2017) Linda Xiaoyan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Serum TWEAK as a biomarker for disease activity of systemic lupus erythematosus

(2016) Jung-Yoon Choe et al.   INFLAMMATION RESEARCH

TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-κB pathway and ERK activation

(2015) Sergio Berzal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

2-Deoxy-D-Glucose Ameliorates PKD Progression

(2015) M. Chiaravalli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascular Endothelial Growth Factor C for Polycystic Kidney Diseases

(2015) J. L. Huang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling

(2015) Evan M Cherry et al.   Molecular Cancer

Molecular Pathways and Therapies in Autosomal-Dominant Polycystic Kidney Disease

(2015) Takamitsu Saigusa et al.   PHYSIOLOGY

An mTOR anti-sense oligonucleotide decreases polycystic kidney disease in mice with a targeted mutation in Pkd2

(2014) Kameswaran Ravichandran et al.   HUMAN MOLECULAR GENETICS

The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair

(2014) Kenta Moriwaki et al.   IMMUNITY

Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury

(2014) J. Belliere et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TWEAK and the progression of renal disease: clinical translation

(2014) A. B. Sanz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast

(2013) Alvaro C. Ucero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fn14 in podocytes and proteinuric kidney disease

(2013) Maria Dolores Sanchez-Niño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Anti-TWEAK Monoclonal Antibody in Patients With Rheumatoid Arthritis

(2013) Nicolas Wisniacki et al.   CLINICAL THERAPEUTICS

Macrophages promote polycystic kidney disease progression

(2013) Katherine I Swenson-Fields et al.   KIDNEY INTERNATIONAL

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Role of interstitial inflammation in the pathogenesis of polycystic kidney disease

(2013) Michelle HT Ta et al.   NEPHROLOGY

Parallel Analysis of mRNA and microRNA Microarray Profiles to Explore Functional Regulatory Patterns in Polycystic Kidney Disease: Using PKD/Mhm Rat Model

(2013) Harsh Dweep et al.   PLoS One

TWEAK/Fn14 and Non-Canonical NF-kappaB Signaling in Kidney Disease

(2013) Jonay Poveda et al.   Frontiers in Immunology

Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease

(2012) Z. Novalic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TWEAK (tumor necrosis factor–like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation

(2012) María Concepción Izquierdo et al.   KIDNEY INTERNATIONAL

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophages Promote Cyst Growth in Polycystic Kidney Disease

(2011) A. Karihaloo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Primary Cilia Upregulates Renal Hypertrophic Signaling and Promotes Cystogenesis

(2011) P. D. Bell et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TWEAK, a multifunctional cytokine in kidney injury

(2011) Ana Belen Sanz et al.   KIDNEY INTERNATIONAL

Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

(2010) Iram Zafar et al.   KIDNEY INTERNATIONAL

Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury

(2010) Kiyohiko Hotta et al.   KIDNEY INTERNATIONAL

TWEAK Activates the Non-Canonical NFκB Pathway in Murine Renal Tubular Cells: Modulation of CCL21

(2010) Ana B. Sanz et al.   PLoS One

Soluble TWEAK Plasma Levels as a Novel Biomarker of Endothelial Function in Patients with Chronic Kidney Disease

(2009) M. I. Yilmaz et al.   Clinical Journal of the American Society of Nephrology

TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells

(2009) Hua-Xin Gao et al.   CYTOKINE

Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways

(2009) H. Happe et al.   HUMAN MOLECULAR GENETICS

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease

(2009) Ayumi Takakura et al.   HUMAN MOLECULAR GENETICS

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks

(2009) Xuewen Song et al.   HUMAN MOLECULAR GENETICS

Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*

(2009) Cristina Vincent et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tweak induces proliferation in renal tubular epithelium: a role in uninephrectomy induced renal hyperplasia

(2009) Ana B. Sanz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pkd1 Haploinsufficiency Increases Renal Damage and Induces Microcyst Formation following Ischemia/Reperfusion

(2009) A. P. Bastos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Microarray-based approach identifies microRNAs and their target functional patterns in polycystic kidney disease

(2008) Priyanka Pandey et al.   BMC GENOMICS

Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia

(2008) Vishal Patel et al.   HUMAN MOLECULAR GENETICS

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

The Cytokine TWEAK Modulates Renal Tubulointerstitial Inflammation

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

(2008) Milena Traykova-Brauch et al.   NATURE MEDICINE

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

(2008) Jeffrey A. Winkles   NATURE REVIEWS DRUG DISCOVERY