HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

SERINC5 protein inhibits HIV-1 fusion pore formation by promoting functional inactivation of envelope glycoproteins

(2017) Chetan Sood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction

(2017) Xianfeng Zhang et al.   JOURNAL OF VIROLOGY

The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

(2016) Anke Heigele et al.   Cell Host & Microbe

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation

(2016) Sherry T. Shu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

(2016) Birthe Trautz et al.   JOURNAL OF VIROLOGY

S2 from equine infectious anemia virus is an infectivity factor which counteracts the retroviral inhibitors SERINC5 and SERINC3

(2016) Ajit Chande et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Interplay Between Murine Leukemia Virus Glycogag, Serinc5, and Surface Glycoprotein Governs Virus Entry, with Opposite Effects on Gammaretroviral and Ebolavirus Glycoproteins

(2016) Yadvinder S. Ahi et al.   mBio

HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

(2016) Brennan S. Dirk et al.   Scientific Reports

SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef

(2015) Yoshiko Usami et al.   NATURE

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation

(2015) Annachiara Rosa et al.   NATURE

Adaptor protein complexes and intracellular transport

(2014) Sang Yoon Park et al.   BIOSCIENCE REPORTS

Interaction of HIV-1 Nef Protein with the Host Protein Alix Promotes Lysosomal Targeting of CD4 Receptor

(2014) Nathaly A. Amorim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with the Src Homology (SH3-SH2) Region of the Src-family Kinase Hck Structures the HIV-1 Nef Dimer for Kinase Activation and Effector Recruitment

(2014) John Jeff Alvarado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4

(2014) Xuefeng Ren et al.   eLife

An interdomain binding site on HIV-1 Nef interacts with PACS-1 and PACS-2 on endosomes to down-regulate MHC-I

(2012) Jimmy D. Dikeakos et al.   MOLECULAR BIOLOGY OF THE CELL

MicroRNAs: big influence in brain evolution

(2012) Sian Lewis   NATURE REVIEWS NEUROSCIENCE

Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef

(2012) Xiaofei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

(2011) Eric B. Dammer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Rab GTPases in Membrane Traffic and Cell Physiology

(2011) Alex H. Hutagalung et al.   PHYSIOLOGICAL REVIEWS

HIV-1 Nef Dimerization Is Required for Nef-Mediated Receptor Downregulation and Viral Replication

(2009) Jerrod A. Poe et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Immunodeficiency Virus Type 1 Nef Protein Targets CD4 to the Multivesicular Body Pathway

(2009) L. L. P. daSilva et al.   JOURNAL OF VIROLOGY

Interactions between SIVNef, SIVGagPol and Alix correlate with viral replication and progression to AIDS in rhesus macaques

(2009) Luciana Jesus da Costa et al.   VIROLOGY

Bimolecular Fluorescence Complementation (BiFC) Analysis as a Probe of Protein Interactions in Living Cells

(2008) Tom K. Kerppola   Annual Review of Biophysics

HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation

(2008) Katelyn M. Atkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Nef Induces a Rab11-Dependent Routing of Endocytosed Immune Costimulatory Proteins CD80 and CD86 to the Golgi

(2008) Ashutosh Chaudhry et al.   TRAFFIC