Article
Oncology
Ahmad Hamad, Timothy M. Pawlik, Aslam Ejaz
Summary: Enhanced recovery after surgery protocols following pancreaticoduodenectomy aim to reduce surgical stress, minimize practice variation, and accelerate postoperative recovery. Key factors for success include patient and provider education, preoperative oral nutrition, goal-directed IV fluid management, early oral diet advancement, multimodal analgesia, early mobilization, normoglycemia, and timely removal of intra-abdominal drains.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Linxi Zhu, Taishun Li, Yifei Yang, Neng Tang, Xu Fu, Yudong Qiu
Summary: This study developed and validated a predictive nomogram for predicting the risk of post-operative abdominal infection in patients undergoing pancreaticoduodenectomy. The nomogram, based on preoperative biliary drainage, CRP, DB, and AKP levels, demonstrated good predictive ability and clinical value.
CLINICA CHIMICA ACTA
(2022)
Article
Surgery
Tzu-Hui Wei, Ping-Jui Su, Wei-Hsun Lu, Ting-Kai Liao, Chih-Jung Wang, Chao-Han Lai, Pin-Hsuan Chiu, Pei-Fang Su, Ying-Jui Chao, Yan-Shen Shan
Summary: This study compared the surgical outcomes of open pancreaticoduodenectomy (OPD) and minimally invasive pancreaticoduodenectomy (MIPD) in obese and non-obese patients. The findings showed that obese MIPD patients experienced more fluid collection, higher Clavien-Dindo (CD) grades, more major complications, and longer operative times compared to obese OPD patients. Non-obese MIPD patients had less blood loss and lower CD grades compared to non-obese OPD patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Ronit Patnaik, Mustafa Tamim Alam Khan, Ince Spencer, Hassan Aziz
Summary: This study investigated the impact of chronic kidney disease (CKD) on patients undergoing pancreaticoduodenectomy. The results demonstrated that the severity of CKD was associated with overall complications and outcomes after the surgery. Therefore, the classification of CKD should be strongly considered in preoperative risk stratification for these patients.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Jennifer A. Yonkus, Roberto Alva-Ruiz, Amro M. Abdelrahman, Susan E. Horsman, Scott A. Cunningham, Travis E. Grotz, Rory L. Smoot, Sean P. Cleary, David M. Nagorney, Michael L. Kendrick, Mark J. Truty
Summary: This prospective study compared culture differences between traditional bile duct swab and bile duct aspiration intraoperative samples in patients undergoing pancreatic head resection. The results showed that bile duct aspiration yielded a significantly higher number of organisms compared to bile duct swab, with anaerobic cultures being positive in patients with bile duct aspiration. Bile duct culture organisms correlated with postoperative surgical site infection, and preoperative biliary stenting was highly associated with positive cultures. The findings suggest that bile duct aspiration may improve the efficacy of antimicrobial prophylaxis in these patients.
Article
Oncology
Chao Wu, Sheng Zhong Hou, Zuowei Wu, Xing Huang, Zihe Wang, Bole Tian
Summary: In this study, a nomogram was constructed using data from patients with pancreatic head cancer who underwent radical pancreaticoduodenectomy, revealing that prognostic nutritional index, lymph node ratio, and staging were independent prognostic factors. The nomogram showed high accuracy in predicting the prognosis of patients with pancreatic head cancer, suggesting its potential for guiding optimal therapeutic schedules for malnourished patients and improving treatment efficacy.
Article
Immunology
Minghua Ma, Guo Li, Baoyong Zhou, Kaili Li, Zhongjun Wu, Lingwang Kong, Maoyun Liu, Miao Liu, Cheng Zhang, Huarong Yu, Shuaiqi Wang, Zuotian Huang, Kezhen Zong
Summary: This study found that postoperative inflammation-related indices and blood cell counts are associated with various complications after pancreaticoduodenectomy (PD). Neutrophil-to-lymphocyte ratio and platelet count can serve as primary indicators post-surgery for monitoring complications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Yi-Fu Chen, Chih-Po Hsu, Jun-Te Hsu, Chun-Wei Huang, Chih-Yuan Fu, I-Ming Kuo, Ming-Yang Chen, Shih-Chun Chang, Shang-Yu Wang, Chun-Nan Yeh, Tsann-Long Hwang
Summary: The study showed that a highest DFA level beyond 2014.5 U/L on postoperative day three after PD is an independent predictor for CR-POPF, and is not significantly associated with 30-day surgical mortality rate, length of stay, and need for postoperative interventions.
ASIAN JOURNAL OF SURGERY
(2021)
Review
Oncology
Yinyin Fan, Nianxing Li, Jing Zhang, Qiaomei Fu, Yudong Qiu, Yan Chen
Summary: This meta-analysis investigates the effects of immunonutrition (IMN) on the prognosis of pancreaticoduodenectomy (PD) patients. The results show that IMN significantly shortens hospital stays and reduces the incidence of infectious complications in PD patients, but has no significant impact on non-infectious complications, postoperative pancreatic fistula, delayed gastric emptying, mortality rates, duration of systemic inflammatory response syndrome, and levels of IL-6 and CRP.
Article
Oncology
Chao Dang, Min Wang, Tingmei Wang, Renyi Qin
Summary: Intraoperative pH is an independent prognostic factor for patients with periampullary carcinoma undergoing pancreaticoduodenectomy, with the low-pH group having a worse short-term prognosis. Patients who underwent laparoscopic surgery had a more alkaline pH after surgery.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Przemyslaw Witek, Marek Bolanowski, Katarzyna Szamotulska, Agnieszka Wojciechowska-Luzniak, Aleksandra Jawiarczyk-Przybylowska, Marcin Kaluzny
Summary: The study aimed to evaluate the glucose metabolism in acromegaly patients treated with pasireotide LAR, showing a decrease in GH levels but worsening of metabolic status with increased HbA1c levels, necessitating intensifying antihyperglycemic treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
T. A. K. A. H. I. R. O. Yamanaka, N. O. R. I. F. U. M. I. Harimoto, R. Y. O. Muranushi, K. O. U. K. Hoshino, K. E. Hagiwara, N. O. R. I. H. I. R. O. Ishii, M. A. R. I. K. O. Tsukagoshi, A. K. I. R. A. Watanabe, K. E. N. I. C. H. I. R. O. Araki, K. E. N. Shirabe
Summary: This study investigated the potential risk for postoperative pancreatic fistula (POPF) in patients undergoing pancreaticoduodenectomy. It found that low bone mineral density (BMD), especially in patients with soft pancreas, was an independent risk factor for POPF. Preoperative assessment of osteopenia may be useful in predicting the occurrence of POPF, and vitamin D supplementation before surgery may be considered for patients with osteopenia.
ANTICANCER RESEARCH
(2022)
Article
Surgery
DeFei Hong, HuaGen Li, XiaoLong Liu, Peiqiang Jiang, Guangsheng Yu, Xueqing Liu, Jianhua Liu, YaHui Liu, Jun Liu, Wan Yee Lau
Summary: This prospective multicenter study aimed to investigate the incidence of postoperative pancreatice fistula and the technique of pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy (LPD). The results showed that the pancreaticojejunostomy technique in LPD is safe, simple, and reproducible, with favorable clinical outcomes.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Meteorology & Atmospheric Sciences
Wei Wei, Xindong Peng, Yanluan Lin, Jianduo Li, Guo Zhang, Yang Yang, Jingchao Long
Summary: The new scale-aware algorithm (SA-UW) developed based on the University of Washington Moist Turbulence scheme adequately reproduces sub-grid turbulence transport at gray-zone scales, vastly improving the distribution and intensity of coherent structures. This new method demonstrates its scale-aware capability by recovering the conventional UW scheme when grid spacing is larger than the turbulence length scale.
JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS
(2022)
Article
Surgery
Kristin C. Potter, Thomas L. Sutton, Jack O'Grady, Erin W. Gilbert, Rodney Pommier, Skye C. Mayo, Brett C. Sheppard
Summary: Postoperative pancreatic fistulas (POPFs) are common complications that often require intervention. Pasireotide is a commonly used preventive measure, but the risk factors for POPFs in patients receiving pasireotide have not been explored. This study found that current smoking was significantly associated with clinically-relevant POPF. Additionally, shortening the course of pasireotide did not increase the risk of clinically-relevant POPF, suggesting that selective discontinuation may be suitable for low-risk patients.
AMERICAN JOURNAL OF SURGERY
(2022)
Review
Oncology
Seifeldin Awad, Ahmad M. Alkashash, Magi Amin, Samantha J. Baker, J. Bart Rose
FRONTIERS IN ONCOLOGY
(2020)
Article
Surgery
Michael T. LeCompte, Keenan J. Robbins, Greg A. Williams, Dominic E. Sanford, Chet W. Hammill, Ryan C. Fields, William G. Hawkins, Steven M. Strasberg
Summary: Subtotal fenestrating cholecystectomy is a useful technique to avoid biliary injury in difficult gallbladders, with high rates of surgical success and low incidence of complications.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Ola Ahmed, John W. Ohman, Neeta Vachharajani, Motoyo Yano, Dominic E. Sanford, Chet Hammill, Ryan C. Fields, William G. Hawkins, Steven M. Strasberg, Maria B. Doyle, William C. Chapman, Adeel S. Khan
Summary: Portal vein aneurysms typically have a stable course over time with minimal complications. Non-operative management is feasible for most patients, with surgical intervention reserved for necessary cases.
Review
Oncology
Francesco Giovinazzo, Fiammetta Soggiu, Jin-Young Jang, Eva Versteijne, Geertjan van Tienhoven, Casper H. van Eijck, Youngmin Han, Seong Ho Choi, Chang Moo Kang, Mark Zalupski, Hasham Ahmad, Sarah Yentz, Scott Helton, J. Bart Rose, Chie Takishita, Yuichi Nagakawa, Mohammad Abu Hilal
FRONTIERS IN ONCOLOGY
(2020)
Editorial Material
Surgery
Sanket Srinivasa, Chet W. Hammill, Steven M. Strasberg
ANZ JOURNAL OF SURGERY
(2021)
Article
Oncology
Tyler R. McCaw, Evelyn Inga, Herbert Chen, Renata Jaskula-Sztul, Vikas Dudeja, James A. Bibb, Bin Ren, J. Bart Rose
Summary: Gamma secretase inhibitors (GSIs), originally developed as Alzheimer's therapies, have been repurposed as anticancer agents due to their ability to inhibit Notch receptor cleavage. Despite showing promise in preclinical models, GSIs have not demonstrated significant clinical benefit in most solid tumors. Further research is needed to address limitations in understanding GSI mechanisms and improve their efficacy in cancer treatment.
Article
Endocrinology & Metabolism
Shabnam Ghazizadeh, Tracy L. Kelly, Yashodhan S. Khajanchee, Jessica Fleser, Yelena Rozenfeld, Michael Neuman, Chet W. Hammill, Lauren Orr, Shaghayegh Aliabadi-Wahle
Summary: Standardization of thyroid imaging protocol and management recommendations can reduce the number of FNAs performed and increase the percentage of positive tests in a community setting.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Surgery
Jorge G. Zarate Rodriguez, Heidy Cos, Gregory A. Williams, Cheryl A. Woolsey, Ryan C. Fields, Steven M. Strasberg, Majella B. Doyle, Adeel S. Khan, William C. Chapman, Chet W. Hammill, William G. Hawkins, Dominic E. Sanford
Summary: This study found that non-white patients undergoing pancreaticoduodenectomy are more likely to experience readmission, particularly for non-severe complications. Therefore, follow-up protocols should be tailored to address race disparities in readmission rates.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Surgery
Juliet S. Okoroh, Lauren Weaver, Martin J. Heslin, Selwyn M. Vickers, Thomas N. Wang, J. Bart Rose, Sushanth Reddy
Summary: The study on patients undergoing pancreatic resection at an academic institution revealed that most patients had insurance and hospital bill adjustments, resulting in the majority of patients not facing catastrophic health expenditure risk exceeding 10% of their estimated median household income.
AMERICAN JOURNAL OF SURGERY
(2021)
Letter
Oncology
Katharine E. Caldwell, Chet W. Hammill
CANCER PREVENTION RESEARCH
(2021)
Article
Oncology
Kristin N. Kelly, Francisco Macedo, Max Seaton, Gregory Wilson, Chet Hammill, Robert C. Martin, Ugwuji N. Maduekwe, Hong J. Kim, Shishir K. Maithel, Daniel E. Abbott, Syed A. Ahmad, David A. Kooby, Nipun B. Merchant, Jashodeep Datta
Summary: In a cohort of PDAC patients undergoing pancreaticoduodenectomy following neoadjuvant therapy, PS:R0 resection is associated with improved overall survival compared to converted-R0 or PS:R1 resection. Pursuing a negative neck margin intraoperatively if the initial margin is positive does not appear to be associated with improved survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Jorge Zarate Rodriguez, Carla Edgley, Sanghee Lee, Natasha Leigh, Rachel Wolfe, Dominic Sanford, Chet Hammill
Summary: Preoperative TAP block is associated with decreased intraoperative opiate use during minimally invasive cholecystectomy. Chronic cholecystitis is associated with increased intraoperative opiate use. Preoperative TAP block should be considered for routine use.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Endocrinology & Metabolism
Vikram S. Pothuri, Michael Anzelmo, Emily Gallaher, Yetunde Ogunlana, Shaghayegh Aliabadi-Wahle, Benjamin Tan, Jeffrey S. Crippin, Chet W. Hammill
Summary: This study aimed to evaluate the risk of hepatobiliary neoplasms in transgender males undergoing gender-affirming hormone therapy (GAHT) with testosterone. The results of this review suggest that there is currently insufficient evidence to conclude an association between GAHT and hepatobiliary neoplasms. The heterogeneity of testosterone formulations limits the ability to translate the risks of hepatobiliary neoplasms from other indications to GAHT.
ENDOCRINE PRACTICE
(2023)
Article
Gastroenterology & Hepatology
Usman Panni, Rohit Srivastava, Alice Bewley, Gregory A. Williams, Ryan C. Fields, Dominic E. Sanford, William G. Hawkins, Natasha Leigh, Chet W. Hammill
Summary: A retrospective analysis found that postoperative use of proton pump inhibitors (PPIs) after pancreatoduodenectomy is associated with an increased risk of overall complications and delayed gastric emptying, but does not affect infectious complications, postoperative pancreatic fistula, or anastomotic leaks. All cases of marginal ulcers occurred in the PPI-treated group.
Article
Oncology
Katharine E. Caldwell, Alexander P. Conway, Chet W. Hammill
Summary: Research on pancreatic cancer screening suggests limited overall survival benefits, while focusing on increasing the number of surgery candidates and improving surgical outcomes would have greater population benefits.
CANCER PREVENTION RESEARCH
(2021)