Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

The mitochondrial permeability transition: A current perspective on its identity and role in ischaemia/reperfusion injury

(2015) Andrew P. Halestrap et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclophilin inhibition as potential therapy for liver diseases

(2014) Nikolai V. Naoumov   JOURNAL OF HEPATOLOGY

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis

(2013) Wei Huang et al.   GUT

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

(2013) Hong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

(2013) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and pancreatitis

(2012) Anna S. Gukovskaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Preventing Pancreatitis by Protecting the Mitochondrial Permeability Transition Pore

(2012) Markus M. Lerch et al.   GASTROENTEROLOGY

Effects of Oxidative Alcohol Metabolism on the Mitochondrial Permeability Transition Pore and Necrosis in a Mouse Model of Alcoholic Pancreatitis

(2012) Natalia Shalbueva et al.   GASTROENTEROLOGY

Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5

(2012) Shiori Sekine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin

(2012) Kamaldeen A. Muili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

(2011) Rafaz Hoque et al.   GASTROENTEROLOGY

Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

(2011) David M. Booth et al.   GASTROENTEROLOGY

Intracellular activation of trypsinogen in transgenic mice induces acute but not chronic pancreatitis

(2011) S. Gaiser et al.   GUT

Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity

(2011) S. Navina et al.   Science Translational Medicine

Dynamic Changes in Cytosolic and Mitochondrial ATP Levels in Pancreatic Acinar Cells

(2010) Svetlana G. Voronina et al.   GASTROENTEROLOGY

Organ Failure and Infection of Pancreatic Necrosis as Determinants of Mortality in Patients With Acute Pancreatitis

(2010) Maxim S. Petrov et al.   GASTROENTEROLOGY

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

(2010) John W. Elrod et al.   JOURNAL OF CLINICAL INVESTIGATION

TRO40303, a New Cardioprotective Compound, Inhibits Mitochondrial Permeability Transition

(2010) S. Schaller et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis

(2009) Kai-Feng Sung et al.   EXPERIMENTAL CELL RESEARCH

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors

(2009) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS

(2009) Laura Lossi et al.   PROGRESS IN NEUROBIOLOGY

Direct Activation of Cytosolic Ca2+ Signaling and Enzyme Secretion by Cholecystokinin in Human Pancreatic Acinar Cells

(2008) John A. Murphy et al.   GASTROENTEROLOGY

Mechanisms regulating cytochrome c release in pancreatic mitochondria

(2008) I V Odinokova et al.   GUT

Polarized Calcium Signaling in Exocrine Gland Cells

(2007) Ole H. Petersen et al.   Annual Review of Physiology