Review
Nutrition & Dietetics
Anna Zasowska-Nowak, Piotr Jan Nowak, Aleksandra Cialkowska-Rysz
Summary: Carotenoids, as a group of natural compounds, may have potential benefits in relieving cancer-related symptoms, such as neuropathic pain and cancer-related cachexia, in patients receiving palliative care.
Article
Anesthesiology
Jacob Dreiher, Tatiana Talya Fleishman, Pesach Shvartzman
Summary: The study found that most maintenance hemodialysis patients were inappropriately treated for pain, with about one third receiving opioid therapy. There is a need for improvement in pain management to enhance treatment satisfaction for patients.
Article
Critical Care Medicine
Alexandre Bourdiol, Vincent Legros, Fanny Vardon-Bounes, Thomas Rimmele, Paul Abraham, Clement Hoffmann, Claire Dahyot-Fizelier, Maud Jonas, Pierre Bouju, Cedric Cirenei, Yoann Launey, Gregoire Le Gac, Samia Boubeche, Edouard Lamarche, Olivier Huet, Lucillia Bezu, Julie Darrieussecq, Magdalena Szczot, Agathe Delbove, Johan Schmitt, Sigismond Lasocki, Johann Auchabie, Ludivine Petit, Emmanuelle Kuhn-Bougouin, Karim Asehnoune, Hugo Ingles, Antoine Roquilly, Raphael Cinotti
Summary: This multicenter prospective study investigated the prevalence, risk factors, and medical management of persistent pain symptoms in patients with ICU length of stay >= 48 h. The study found that persistent pain symptoms were frequent in critical illness survivors, but specialized pain management remained infrequent.
Article
Biochemistry & Molecular Biology
Edurne Ubeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia Maria Gallego-Sendarrubias, Cesar Fernandez-de-Las-Penas, Jose Luis Arias-Buria, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigaran-Mendez
Summary: This study found a good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of the condition and hence provide synergistic information.
Article
Anesthesiology
Oystein Dunker, Margreth Grotle, Marie Bu Kvaloy, Martin Uglem, Sissel Loseth, Ina Elen Hjelland, Inge Petter Kleggetveit, Sara Maria Allen, Maria Dehli Vigeland, Rikke Munk Killingmo, Trond Sand, Kristian Bernhard Nilsen
Summary: This study aimed to investigate the diagnostic accuracy of 3 tools commonly used to differentiate between neuropathic and nonneuropathic pain. The results showed that neither DN4, painDETECT, nor S-LANSS can be confidently used to assess neuropathic pain.
Review
Oncology
Elena Ruggiero, Irene Tizianel, Mario Caccese, Giuseppe Lombardi, Ardi Pambuku, Vittorina Zagonel, Carla Scaroni, Fabio Formaglio, Filippo Ceccato
Summary: Adrenocortical cancer (ACC) is a rare malignancy with a poor prognosis. The best management approach involves a multidisciplinary team and can improve survival. Even in advanced cases, multimodal treatments and skillful management can lead to significant improvements in survival. However, patients with advanced ACC often suffer from severe physical and psychological symptoms and experience a decline in quality of life. The early integration of supportive and palliative care can alleviate the burden on cancer patients, mediate aggressive treatments, and improve their quality of life.
Article
Neurosciences
De-Li Cao, Ling-Jie Ma, Bao-Chun Jiang, Qiang Gu, Yong-Jing Gao
Summary: CYP26A1 is upregulated in the spinal cord after spinal nerve ligation and its inhibition can alleviate neuropathic pain by promoting IL-10 expression and suppressing glial activation. CYP26A1 may be a potential therapeutic target for the treatment of neuropathic pain.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: The study showed that rosmarinic acid can improve cell viability, reduce inflammatory factors, and decrease microglial senescence markers, suggesting its potential as a pharmacological target for controlling symptoms of peripheral neuropathy.
Article
Neurosciences
Hong Jiang, Jiang-Ping Liu, Ke Xi, Ling-Yu Liu, Ling-Yu Kong, Jie Cai, Si-Qing Cai, Xi-Yuan Han, Jing-Gui Song, Xiao-Mei Yang, You Wan, Guo-Gang Xing
Summary: The study revealed the crucial role of the amygdala in processing sensory and emotional-affective components of neuropathic pain, with bilateral lesions of the CeA abolishing pain hypersensitivity and aversive/depressive symptoms in rats. Furthermore, structural and functional neuroplasticity in the amygdala, along with endocytosis of GluA2-containing AMPARs, may play a role in comorbid aversive and depressive symptoms in chronic pain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Rehabilitation
Debasish Jena, Jagannatha Sahoo, Apurba Barman, Anil Gupta, Vikas Patel
Summary: This study investigated the prevalence of musculoskeletal and neurological pain symptoms among hospitalized COVID-19 patients. It found that pain symptoms are common manifestations of COVID-19, with generalized myalgia, headache, and low back pain being the most common symptoms. The study also revealed an association between pain symptoms and disease severity, male sex, higher body mass index, and a history of addiction.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Urology & Nephrology
Kelly H. Beers, C. John Sperati, David S. Weisman, Khaled Abdel-Kader, Sandeep Soman, Laura Plantinga, Michael J. Choi, Bernard G. Jaar, Raquel C. Greer
Summary: The article discusses the role, challenges, and improvement strategies of primary care for patients receiving hemodialysis, while also suggesting future research needs for enhancing primary care delivery for this high-risk population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Oncology
Jonas Sorensen, Per Sjogren, Stine Novrup Clemmensen, Tanja Vibeke Sorensen, Katja Heinecke, Geana Paula Kurita
Summary: The study compared symptom prevalence and analgesic treatment in adult in-patients at a comprehensive cancer center in 2011 and 2019. While overall symptom burden remained high, there was an improvement in pain management in 2019 with significant increase in prescription of opioid and adjuvant analgesics.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Critical Care Medicine
Christopher E. Cox, Jessie Gu, Deepshikha Charan Ashana, Elias H. Pratt, Krista Haines, Jessica Ma, Maren K. Olsen, Alice Parish, David Casarett, Mashael S. Al-Hegelan, Colleen Naglee, Jason N. Katz, Yasmin Ali O'Keefe, Robert W. Harrison, Isaretta L. Riley, Santos Bermejo, Katelyn Dempsey, Kimberly S. Johnson, Sharron L. Docherty
Summary: This study aimed to describe trajectories of palliative care needs during ICU care and determine if changes in needs over 1 week were associated with similar changes in psychological distress symptoms at 3 months. The results showed that serious palliative care needs were common and persistent among families during ICU care, but improvement in needs did not alleviate psychological distress at 3 months.
CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Sandhya Jinesh, Justin Kullgren, Gollapudi S. Shankar, Rajan Radhakrishnan
Summary: Neuropathic pain is a chronic condition affecting around 1% of the general population globally, with various underlying causes and challenging treatment options. Non-traditional analgesics are commonly used to treat this condition, with opioids being effective in some cases but carrying risks of addiction and adverse effects. Future prospects for the treatment of neuropathic pain involve further research and exploration.
INFLAMMOPHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Sasson Menahem, Tali Samson, Pesach Shvartzman
AMERICAN JOURNAL OF HOSPICE & PALLIATIVE MEDICINE
(2018)
Article
Health Care Sciences & Services
Tali Samson, Pesach Shvartzman
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2018)
Article
Anesthesiology
Maya Lavie-Ajayi, Pesach Shvartzman
Article
Cardiac & Cardiovascular Systems
Yonatan Reuven, Pesach Shvartzman, Jacob Dreiher
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Geriatrics & Gerontology
A. Mark Clarfield, Tzvi Dwolatzky, Shai Brill, Yan Press, Shimon Glick, Pesach Shvartzman, Israel (Issi) Doron
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2020)
Article
Health Care Sciences & Services
Tatiana Talya Fleishman, Jacob Dreiher, Pesach Shvartzman
QUALITY OF LIFE RESEARCH
(2020)
Article
Psychiatry
G. Eger, Y. Reuven, J. Dreiher, P. Shvartzman, M. Weiser, D. Aizenberg, A. Weizman, S. Lev-Ran
Summary: The study compares the rates of schizophrenia among 1st and 2nd generation immigrants from different backgrounds and emphasizes the increased risk among 2nd generation immigrants and pioneer groups. This highlights the importance of continuous investment in acculturation and calls for further research on the impact of country of origin and ethnic density on schizophrenia risk.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Oncology
Daniel Dayan, Sasson Menahem, Pesach Shvartzman
Summary: The study investigated the provision of subcutaneous hydration in a home care hospice unit and its potential connection to death rattle. Results showed that some patients received subcutaneous hydration, but a significant association between hydration and death rattle was not demonstrated. Males were more likely to receive hydration and had a higher incidence of death rattle compared to females.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Anesthesiology
Jacob Dreiher, Tatiana Talya Fleishman, Pesach Shvartzman
Summary: The study found that most maintenance hemodialysis patients were inappropriately treated for pain, with about one third receiving opioid therapy. There is a need for improvement in pain management to enhance treatment satisfaction for patients.
Article
Multidisciplinary Sciences
Yehudit Bloch, R. H. Belmaker, Pesach Shvartzman, Pnina Romem, Arkady Bolotin, Yuly Bersudsky, Abed N. Azab
Summary: This study demonstrates that normobaric oxygen treatment has a significant therapeutic effect on symptoms of depression, particularly in improving HRSD and CGI scores.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Maya Maor, Moflah Ataika, Pesach Shvartzman, Maya Lavie Ajayi
Summary: This study examines the distinct challenges and coping strategies faced by the Bedouin minority in Israel in dealing with type 2 diabetes. The findings highlight the physical and social inequalities experienced by the Bedouins and how they actively cope with the disease by adapting their lifestyle and utilizing elements of their local culture.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Yuval Shalev Many, Pesach Shvartzman, Ido Wolf, Barbara G. Silverman
Summary: This study analyzed clinical and demographic characteristics of 209,158 cancer deaths in Israel between 1998 and 2018. The proportion of out-of-hospital deaths increased annually, with older patients and those with solid malignancies more likely to die at home. The study highlights the importance of increasing access to end-of-life care and educating patients, families, and physicians about the benefits of palliative care.
Letter
Primary Health Care
Aya Biderman, Yosef Avni, Sody Naimer, Yosef Polachek, Hava Tabenkin, Pesach Shvartzman
Article
Health Policy & Services
Tali Samson, Pesach Shvartzman
PALLIATIVE & SUPPORTIVE CARE
(2018)