Article
Chemistry, Multidisciplinary
Xuehui Zheng, Lingxin Liu, Jing Liu, Chen Zhang, Jie Zhang, Yan Qi, Lin Xie, Chunmei Zhang, Guoqing Yao, Peili Bu
Summary: The study shows that adverse remodeling after myocardial infarction (MI) is associated with heart failure and sudden cardiac death. Fibulin7 (FBLN7) is a critical profibrotic regulator of post-MI cardiac remodeling. FBLN7 binds to the epidermal growth factor receptor (EGFR) and induces autophosphorylation of EGFR, leading to fibroblast-to-myofibroblast transdifferentiation and myocardial fibrosis.
Article
Medicine, Research & Experimental
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Veronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S. P. Lam, Mark Y. Chan, Dominique P. V. de Kleijn, Jiong-Wei Wang
Summary: The study found that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling by regulating inflammation and angiogenesis. Targeted inhibition of TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling.
Article
Engineering, Biomedical
Yanxin Zhang, Xin Li, Zhaowenbin Zhang, Huili Li, Dongmin Chen, Yiren Jiao, Chen Fan, Zhen Zeng, Jiang Chang, Yuhong Xu, Baowei Peng, Chen Yang, Yumei Que
Summary: This study developed a Zn2SiO4 bioceramic that can release bioactive SiO32- and Zn2+ ions simultaneously, which have synergistic effects on promoting endothelial cell angiogenesis, inhibiting cardiomyocyte apoptosis, and protecting myocardial mitochondria against reactive oxygen species-induced injury. In vivo outcomes from a murine MI model demonstrated that systemic administration or local application of the Zn2SiO4 extract or composite hydrogel promoted cardiac function and reduced cardiac fibrosis, aiding myocardial repair.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Bin Zeng, Xiaoting Liao, Lei Liu, Caixia Zhang, Huaiyu Ruan, Bo Yang
Summary: The study found that T3 pretreatment significantly reduces myocardial infarct area, inhibits cardiomyocyte apoptosis and fibrosis, and improves left ventricular function post-MI. Furthermore, T3 can also promote angiogenesis, reduce inflammatory cytokines, and protect the heart from damage after MI.
Article
Engineering, Biomedical
Yong Wu, Tianqi Chang, Weiqian Chen, Xiaoyu Wang, Jingjing Li, Yueqiu Chen, You Yu, Zhenya Shen, Qian Yu, Yanxia Zhang
Summary: Myocardial infarction is a serious cardiovascular disease with complex pathophysiology. Treatment with injectable composite hydrogel for dual-release of VEGF and BMP9 shows a collaborative effect in promoting angiogenesis and inhibiting myocardial fibrosis, demonstrating significant potential for cardiac clinical application.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
Can Wu, Yuxin Zhang, Yuanyuan Xu, Linyu Long, Xuefeng Hu, Jieyu Zhang, Yunbing Wang
Summary: In this study, an injectable conductive hydrogel (Alg-P-AAV hydrogel) with excellent antioxidative and angiogenic ability was developed by incorporating lignosulfonate-doped polyaniline (PANI/LS) nanorods and adeno-associated virus encoding vascular endothelial growth factor (AAV9-VEGF) in the calcium-crosslinked alginate hydrogel. The therapeutic effect of this multi-functional hydrogel for myocardial infarction (MI) treatment was remarkable.
Article
Cardiac & Cardiovascular Systems
Yu Huang, Liangpeng Li, Hongmei Chen, Qiao Liao, Xiaoli Yang, Dezhong Yang, Xuewei Xia, Hongyong Wang, Wei Eric Wang, Lianglong Chen, Chunyu Zeng
Summary: YY1 expression in the heart was significantly stimulated following myocardial infarction. Overexpression of YY1 improved survival rate, cardiac function, scar size, and left ventricular volume in mice, while silencing YY1 had the opposite effects. YY1 alleviated cardiac apoptosis and fibrosis, promoted angiogenesis, T helper 2 cytokine production, M2 macrophage polarization, and enhanced endothelial cell tube formation and migration ability. Enhanced Akt phosphorylation and vascular endothelial growth factor production were observed in the presence of YY1 overexpression. These effects suggest YY1 as a potential therapeutic target for myocardial infarction.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jianqiu Pei, Lin Cai, Fang Wang, Chuansheng Xu, Shengqiang Pei, Hongwei Guo, Xiaogang Sun, Jerold Chun, Xiangfeng Cong, Weiquan Zhu, Zhe Zheng, Xi Chen
Summary: This study found that the level of lysophosphatidic acid (LPA) was increased in the peripheral blood of mice after myocardial infarction (MI), and the expression of its receptor LPA(2) was also increased in the heart. Deficiency of Lpar2 led to impaired heart function, increased scar size, and reduced vascular density. Mechanistic studies demonstrated that LPA-LPA(2) signaling promoted angiogenesis and maintained vascular homeostasis through multiple signaling pathways.
CIRCULATION RESEARCH
(2022)
Review
Chemistry, Medicinal
Zohreh Varasteh, Wolfgang A. Weber, Christoph Rischpler
Summary: Molecular imaging technologies play a vital role in the detection and treatment of cardiovascular disease, providing unique insights into pathobiological processes and enabling personalized therapy.
Article
Cardiac & Cardiovascular Systems
Xueyi Chen, Pavel Zhabyeyev, Abul K. Azad, Bart Vanhaesebroeck, Chad E. Grueter, Allan G. Murray, Zamaneh Kassiri, Gavin Y. Oudit
Summary: PI3K alpha plays a crucial role in cell survival, hypertrophic response, and angiogenesis, and inhibition of PI3K alpha after myocardial infarction may result in adverse consequences.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ahmet Demirkiran, Rob J. van der Geest, Luuk H. G. A. Hopman, Lourens F. H. J. Robbers, M. Louis Handoko, Robin Nijveldt, John P. Greenwood, Sven Plein, Pankaj Garg
Summary: LV hemodynamic assessment by LV blood flow kinetic energetics in STEMI patients shows a significant inverse association with adverse LV-remodeling. Late-diastolic LV blood flow kinetic energetics early after acute MI is independently associated with adverse LV-remodeling.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Giorgia Panichella, Andrea Barison, Silvia Maffei, Matteo Cameli, Stefano Coiro, Flavio D'Ascenzi, Carlo Di Mario, Riccardo Liga, Rossella Marcucci, Doralisa Morrone, Iacopo Olivotto, Isabella Tritto, Michele Emdin
Summary: Gender differences exist in the epidemiology, clinical features, and outcome of myocardial infarction, with women showing lower propensity to develop spherical geometry and left ventricular dysfunction after MI, attributed to various physiological factors including hormonal influences. Future studies should focus on clarifying these sex differences and potential therapeutic targets.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Engineering, Biomedical
Yuejun Yao, Aoqi Li, Shuqin Wang, Yuwen Lu, Jieqi Xie, Haolan Zhang, Deteng Zhang, Jie Ding, Zhaoyi Wang, Chenxi Tu, Liyin Shen, Lenan Zhuang, Yang Zhu, Changyou Gao
Summary: Myocardial infarction (MI) is a major cause of death and disability globally. A multifunctional cardiac patch has been developed to provide mechanical support to the infarcted myocardium and improve therapeutic outcomes by mediating biological and mechanical treatments.
Review
Nanoscience & Nanotechnology
Jiacheng Fang, Yuxuan Zhang, Delong Chen, Yiyue Zheng, Jun Jiang
Summary: This article summarizes the pathological mechanisms of ventricular remodeling following myocardial infarction and the role of exosomes in these processes, with a focus on the importance of exosomal cargos such as proteins and ncRNAs. It also highlights the potential diagnostic and therapeutic strategies in this field.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nihar Masurkar, Marion Bouvet, Damien Logeart, Charlene Jouve, Fatou Drame, Olivier Claude, Maguelonne Roux, Clement Delacroix, Damien Bergerot, Jean-Jacques Mercadier, Marc Sirol, Barnabas Gellen, Marine Livrozet, Antoine Fayol, Estelle Robidel, David-Alexandre Tregouet, Giovanna Marazzi, David Sassoon, Mariana Valente, Jean-Sebastien Hulot
Summary: After myocardial infarction, the secretion of GDF3 by cardiac stromal cells promotes fibroblast proliferation, leading to adverse fibrotic remodeling.
Article
Cell & Tissue Engineering
Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan, Diego Correa
Summary: The study found that IFP-MSC manufactured as 3D spheroids exhibit enhanced anti-inflammatory and anti-fibrotic effects both in vitro and in vivo, without the need for cell priming. This streamlines cell product manufacturing protocols.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Giacomo Lanzoni, Elina Linetsky, Diego Correa, Shari Messinger Cayetano, Roger A. Alvarez, Dimitrios Kouroupis, Ana Alvarez Gil, Raffaella Poggioli, Phillip Ruiz, Antonio C. Marttos, Khemraj Hirani, Crystal A. Bell, Halina Kusack, Lisa Rafkin, David Baidal, Andrew Pastewski, Kunal Gawri, Clarissa Lenero, Alejandro M. A. Mantero, Sarah W. Metalonis, Xiaojing Wang, Luis Roque, Burlett Masters, Norma S. Kenyon, Enrique Ginzburg, Xiumin Xu, Jianming Tan, Arnold Caplan, Marilyn K. Glassberg, Rodolfo Alejandro, Camillo Ricordi
Summary: The study confirmed safety of UC-MSC infusions in patients with COVID-19 ARDS. By reducing inflammatory cytokines, significant improvement was observed in UC-MSC-treated patients on day 6. The treatment markedly increased patient survival rate, SAE-free survival, and time to recovery.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Dimitrios Kouroupis, Diego Correa
Summary: The detrimental effects of conventional 2D MSC expansion have led to the development of novel techniques, such as 3D culturing, to enhance the functionality and efficacy of MSCs. MSC 3D spheroids exhibit enhanced medicinal signaling activities and improved homing and survival capacities, demonstrating safety and efficacy in preclinical studies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Correction
Cell & Tissue Engineering
Dimitrios Kouroupis, Melissa A. Willman, Thomas M. Best, Lee D. Kaplan, Diego Correa
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Clarissa Lenero, Annie C. Bowles, Diego Correa, Dimitrios Kouroupis
Summary: This study investigated the molecular responses of human endometrial-derived mesenchymal stem/stromal cells (eMSCs) to different culture passages and inflammatory environments, revealing that the response of eMSCs to inflammation significantly affected their functional attributes.
Article
Biotechnology & Applied Microbiology
Carlotta Perucca Orfei, Annie C. Bowles, Dimitrios Kouroupis, Melissa A. Willman, Enrico Ragni, Lee D. Kaplan, Thomas M. Best, Diego Correa, Laura de Girolamo
Summary: The study identified distinct morphological and functional characteristics of TSPCs under different culture densities. TSPCs cultured at low density exhibited better immunomodulatory responses, while TSPCs at high density showed greater differentiation potential. TSPCs demonstrated specific immunophenotypic profiles and immunomodulatory potential in response to inflammatory stimuli.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Medicine, General & Internal
Polyxeni Mantzouratou, Angelo Michele Lavecchia, Christodoulos Xinaris
Summary: The study assesses the role of thyroid hormone signaling in human evolution and finds that it played a critical role in facilitating adaptive responses to changing environments in early humans. These ancient roles have been conserved in modern humans and offer potential therapeutic targets for present-day environmental and pathophysiological stresses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Clarissa Lenero, Lee D. Kaplan, Thomas M. Best, Dimitrios Kouroupis
Summary: This study discovered that endometrial mesenchymal stem/stromal cells (eMSC) and their CD146+ subpopulation possess exosomal secretomes with potent immunomodulatory miRNA attributes. These exosomes are involved in macrophage polarization, T cell activation, and regulation of inflammatory cytokines. The findings suggest that eMSC EXOs could be used for therapeutic purposes in resolving detrimental aspects of tissue inflammation.
Review
Cell Biology
Michael G. G. Rizzo, Thomas M. M. Best, Johnny Huard, Marc Philippon, Francis Hornicek, Zhenfeng Duan, Anthony J. J. Griswold, Lee D. D. Kaplan, Joshua M. M. Hare, Dimitrios Kouroupis
Summary: Osteoarthritis (OA) is the leading cause of disability among the elderly and is increasingly affecting younger individuals. Recent advancements in understanding the pathology of OA have led to the identification of potential therapeutic approaches targeting specific molecular pathways, such as inflammation and cellular senescence. Stem cell therapies and senolytics show promise in controlling patient symptoms and slowing disease progression.
Review
Biochemistry & Molecular Biology
Polyxeni Mantzouratou, Eleftheria Malaxianaki, Domenico Cerullo, Angelo Michele Lavecchia, Constantinos Pantos, Christodoulos Xinaris, Iordanis Mourouzis
Summary: Heart failure affects a large number of people worldwide, leading to significant impact on their survival and quality of life. Understanding the pathophysiology and molecular bases of this condition is crucial for the development of new therapeutic approaches. Thyroid hormone signaling plays a key role in development and metabolism, and its dysregulation is associated with structural remodeling and phenotypical changes in the cardiomyocytes. This review examines the evidence on the role of thyroid hormone in myocardial recovery in heart failure patients and its potential therapeutic implications.
Article
Cell Biology
Dimitrios Kouroupis, Lee D. D. Kaplan, Johnny Huard, Thomas M. M. Best
Summary: The activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory signaling plays a significant role in human inflammatory joint diseases. Intra-articularly injected IFP-derived mesenchymal stem/stromal cells (IFP-MSC) acquire immunomodulatory effects and degrade substance P (SP) via CD10. This study suggests that CD10-bound small extracellular vesicles (IFP-MSC sEVs) have immunomodulatory and chondroprotective effects, providing potential therapeutic options for immune-mediated inflammatory joint changes associated with osteoarthritis (OA).
Editorial Material
Biotechnology & Applied Microbiology
Dimitrios Kouroupis, Lee D. Kaplan, Camillo Ricordi, Thomas M. Best
BIOENGINEERING-BASEL
(2023)
Review
Biotechnology & Applied Microbiology
Max Baron, Philip Drohat, Brooke Crawford, Francis J. Hornicek, Thomas M. Best, Dimitrios Kouroupis
Summary: Osteosarcoma is a type of bone cancer that mainly affects children and young adults. The current standard treatment is a combination of chemotherapy and surgical removal of the tumor, but bone regeneration after surgery remains a challenge. Mesenchymal stem/stromal cells (MSCs) have the potential to enhance bone regeneration, especially when used in conjunction with other methods. Both bone marrow-derived MSCs and adipose tissue-derived MSCs show great potential for stimulating bone regeneration.
BIOENGINEERING-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Dimitrios Kouroupis, Thomas M. Best, Lee D. Kaplan, Diego Correa, Anthony J. Griswold
Summary: In an acute inflammation model, macrophages in the infrapatellar fat pad (IFP) of knee joints exhibited a pro-inflammatory M1 phenotype, which was shifted towards an anti-inflammatory M2 status with IFP-MSC therapy, potentially alleviating joint inflammation progression.
BIOENGINEERING-BASEL
(2021)
Article
Pharmacology & Pharmacy
D. Kouroupis, G. Lanzoni, E. Linetsky, S. Messinger Cayetano, S. Wishnek Metalonis, C. Lenero, L. D. Stone, P. Ruiz, D. Correa, C. Ricordi
Summary: This study aimed to elucidate the therapeutic effect mechanism of Umbilical Cord Mesenchymal Stem Cells (UCMSC) in patients with COVID-19 Acute Respiratory Distress Syndrome (ARDS). Results showed that UCMSC treatment led to significantly increased levels of plasma sTNFR2 and decreased levels of TNF alpha and TNF beta, indicating a decrease in inflammation in COVID-19 ARDS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
