Article
Biotechnology & Applied Microbiology
Peng Zhang, Yusheng Sun, Haizhen Yang, Dong Liu, Feng Zhang, Yu Zhang, Wentao Zhong, Baoqi Zuo, Zhiqiang Zhou
Summary: In this study, a vancomycin delivery system for the treatment of chronic osteomyelitis was developed by entrapping silk fibroin microspheres loaded with vancomycin in an injectable silk hydrogel. The hydrogel exhibited sustained release of vancomycin for up to 25 days and showed strong antibacterial activity against both Escherichia coli and Staphylococcus aureus for 10 days without decrease in efficacy. Injection of the vancomycin-loaded silk fibroin microspheres entrapped in the hydrogel into the infected site of rat tibia resulted in reduced bone infection and improved bone regeneration as compared to other treatment groups.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Tao Wang, Yuqi Li, Jian Liu, Yan Fang, Wenjun Guo, Yu Liu, Xiangyu Li, Gang Li, Xiuli Wang, Zhaozhu Zheng, Xiaoqin Wang, David L. Kaplan
Summary: A silk fibroin hydrogel with high elasticity, anti-fatigue properties, and stable structure and mechanical strength in aqueous solution was prepared using a chemical crosslinker. The hydrogel showed biocompatibility and served as a bio-lubricant for the treatment of osteoarthritis.
Article
Engineering, Biomedical
Can Wu, Yuxin Zhang, Yuanyuan Xu, Linyu Long, Xuefeng Hu, Jieyu Zhang, Yunbing Wang
Summary: In this study, an injectable conductive hydrogel (Alg-P-AAV hydrogel) with excellent antioxidative and angiogenic ability was developed by incorporating lignosulfonate-doped polyaniline (PANI/LS) nanorods and adeno-associated virus encoding vascular endothelial growth factor (AAV9-VEGF) in the calcium-crosslinked alginate hydrogel. The therapeutic effect of this multi-functional hydrogel for myocardial infarction (MI) treatment was remarkable.
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ziyang Sun, Haoran Liu, Dandan Dai, Hao Lyu, Ruochuan Huang, Wenzhao Wang, Chengchen Guo
Summary: This study presents a promising injectable cell-laden hydrogel system based on silk acid, which exhibits good cytocompatibility and injectability. The hydrogel has potential applications in 3D cell culture, targeted cell delivery, and tissue engineering.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Yusheng Sun, Peng Zhang, Feng Zhang, Mengyang Pu, Wentao Zhong, Yu Zhang, Yingchao Shen, Baoqi Zuo
Summary: In this study, silk fibroin nanofiber hydrogels mimicking the extracellular matrix structure were prepared and characterized. The nanofiber solution was processed into an injectable hydrogel and loaded with the antibiotic vancomycin, exhibiting superior antibacterial properties. This study demonstrates the potential of silk fibroin nanofiber hydrogels in tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Kui Wu, Yuanyuan Wang, Hong Yang, Yihuan Chen, Kunyan Lu, Yong Wu, Chunxia Liu, Haixin Zhang, Hanyu Meng, Qian Yu, Yanxia Zhang, Zhenya Shen
Summary: An injectable hydrogel based on a decellularized porcine extracellular matrix (dECM) is developed to encapsulate and deliver cardiomyocytes locally to the infarct area of the heart. This hydrogel exhibits good biocompatibility and chemotactic effects for endogenous cells and endothelial cells, improving cardiac function through promoting angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
V. H. Giang Phan, Mohanapriya Murugesan, P. P. Thanh Nguyen, Cuong Hung Luu, Ngoc-Han Hoai Le, Huong Thi Nguyen, Panchanathan Manivasagan, Eue-Soon Jang, Yi Li, Thavasyappan Thambi
Summary: This study developed an injectable silk fibroin/hyaluronic acid hydrogel scaffold for repairing articular cartilage injuries. The hydrogel scaffold, similar to the natural extracellular microenvironment, had a highly porous network and controlled release of methylprednisolone for tissue regeneration and reducing inflammation. The results showed that the hydrogel scaffold did not affect angiogenesis and could form a gel in vivo, demonstrating its potential for cartilage regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Fang Lei, Jiangfeng Cai, Ruyin Lyu, Honglan Shen, Yalan Xu, Jie Wang, Yajun Shuai, Zongpu Xu, Chuanbin Mao, Mingying Yang
Summary: The study developed an injectable macroporous silk fibroin (SF) microsphere vaccine that can suppress established tumors with a single injection. The macroporous structure of the vaccine facilitates immune cell recruitment and activates dendritic cells, resulting in a favorable immune microenvironment and strong immune response against the tumor.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Linquan Zhou, Zhenyu Wang, Dehui Chen, Jiemin Lin, Wenwen Li, Shengyu Guo, Rongcan Wu, Xin Zhao, Taotao Lin, Gang Chen, Wenge Liu
Summary: This study developed a photocurable silk fibroin hydrogel to deliver basic fibroblast growth factor (bFGF) for spinal cord injury treatment. The hydrogel exhibited slow release of bFGF, promoting nerve axon regeneration, inhibiting glial cell proliferation, improving neuronal mitochondrial function, and suppressing local inflammation and oxidative stress. This novel method provides a new treatment strategy for spinal cord injury.
MATERIALS & DESIGN
(2022)
Article
Engineering, Environmental
Lianlian Wang, Zhijie Chen, Yufei Yan, Chuan He, Xinming Li
Summary: The study presents a new bioactive hydrogel composed of silk fibroin and a self-assembling peptide, which can induce cell adhesion, growth, and migration, as well as stimulate collagen deposition and expression of angiogenesis-related genes/proteins. This bioactive hydrogel shows promise for applications in vascular regeneration and wound healing.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Seongwon Lee, Joohee Choi, Jina Youn, Younghun Lee, Wooyoup Kim, Seungho Choe, Jeongeun Song, Rui L. Reis, Gilson Khang
Summary: This study investigated a ternary hydrogel composed of gellan gum, silk fibroin, and chondroitin sulfate as a biomaterial for cartilage tissue engineering. The hydrogel showed enhanced mechanical properties with higher gellan gum content, but exhibited harsh conditions for cell encapsulation at certain concentrations. The ternary hydrogel exhibited positive cell growth and expression of cartilage-specific ECM and genes, indicating its potential for promoting articular cartilage defect repair in cartilage tissue engineering.
Article
Engineering, Environmental
Yang Liu, Rui Guo, Tengling Wu, Yuanning Lyu, Meng Xiao, Binbin He, Guanwei Fan, Jianhai Yang, Wenguang Liu
Summary: A cell-free and therapeutic drug-free injectable zwitterionic hydrogel with antioxidant ability and intrinsic conductive properties was fabricated, showing positive effects such as promoting cardiovascular growth and reducing cardiac fibrosis after injection into the infarcted region of rats.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing Jiang, Ying-ying Tong, Guang-hua Yang, Li Yang, Yun-bing Wang
Summary: In this study, an injectable self-doping conductive hydrogel was developed for delivering human umbilical cord mesenchymal stem cell secretome to protect cardiac function after myocardial infarction. The conductive hydrogel showed good biocompatibility and conductivity consistent with the natural myocardium, and the secretome was able to promote cell proliferation, migration, and angiogenesis. In a rat MI model, hydrogel injection improved ejection fraction and fraction shortening, and decreased susceptibility to arrhythmia.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Liangyan Sun, Minqi Lu, Ling Chen, Bingjiao Zhao, Jinrong Yao, Zhengzhong Shao, Xin Chen, Yuehua Liu
Summary: Silk fibroin is a promising biomaterial in bone tissue regeneration. The introduction of Laponite (R) into regenerated silk fibroin has resulted in an RSF/LAP hybrid hydrogel that promotes osteogenic differentiation. The hydrogel has demonstrated excellent biocompatibility and improved new bone formation in a rat calvarial defect model.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Kui Wu, Yuanyuan Wang, Hong Yang, Yihuan Chen, Kunyan Lu, Yong Wu, Chunxia Liu, Haixin Zhang, Hanyu Meng, Qian Yu, Yanxia Zhang, Zhenya Shen
Summary: An injectable hydrogel based on a decellularized porcine extracellular matrix (dECM) is developed to encapsulate and deliver cardiomyocytes locally to the infarct area of the heart. This hydrogel exhibits good biocompatibility and chemotactic effects for endogenous cells and endothelial cells, improving cardiac function through promoting angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yuancheng Lin, Haixin Zhang, Yi Zou, Kunyan Lu, Luohuizi Li, Yan Wu, Jingjing Cheng, Yanxia Zhang, Hong Chen, Qian Yu
Summary: In this study, a superhydrophobic photothermal coating was developed to prevent biofilm formation. The coating demonstrated both anti-adhesive and photothermal bactericidal properties, and could be deposited on various substrates, showing great potential for diverse practical applications.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Jianping Yuan, Hong Yang, Chunxia Liu, Lianbo Shao, Haixin Zhang, Kunyan Lu, Jingjing Wang, Yuanyuan Wang, Qian Yu, Yanxia Zhang, Yunsheng Yu, Zhenya Shen
Summary: Myocardial infarction (MI) is a severe cardiovascular disease that leads to uncontrolled and excessive cardiac fibrosis. A biocompatible microneedle patch loaded with exosomes containing miR-29b mimics is developed to prevent fibrosis after MI. The patch effectively delivers the exosomes to cardiac fibroblasts, upregulating miR-29b expression and downregulating fibrosis-related proteins, resulting in reduced inflammation, infarct size, fibrosis, and improved cardiac function in a mouse MI model.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Jiana Chen, Meina Lv, Wenlin Xu, Feilong Zhang, Nianxu Huang, Xia Chen, Wang Zhang, Wei Hu, Jun Su, Hengfen Dai, Ping Gu, Xiaohong Huang, Xiaoming Du, Ruijuan Li, Qiaowei Zheng, Xiangsheng Lin, Yanxia Zhang, Yuxin Liu, Min Zhang, Xiumei Liu, Zhu Zhu, Jianjun Sun, Jinhua Zhang
Summary: The purpose of this study was to identify factors associated with major bleeding in patients with atrial fibrillation on direct oral anticoagulants and construct a predictive model for clinical assessment. The study found that age, bleeding history, anemia, vascular disease, antiplatelet therapy/non-steroidal anti-inflammatory drugs, and rivaroxaban were independent risk factors for major bleeding, while gastrointestinal protective agents were a protective factor. The developed model, named Alfalfa-MB, showed good discriminatory power and calibration in external validation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Chunxia Liu, Yong Wu, Hong Yang, Kunyan Lu, Haixin Zhang, Yuanyuan Wang, Jingjing Wang, Linan Ruan, Zhenya Shen, Qian Yu, Yanxia Zhang
Summary: Myocardial infarction (MI) is a common cardiovascular disease and a major cause of global mortality. Transplantation of exogenous cardiomyocytes (CMs) has emerged as a promising treatment option due to the limited regenerative capacity of endogenous CMs. In this study, an injectable hydrogel composed of alginate and fibrin was developed for localized delivery of neonatal CMs and the angiogenesis agent vascular endothelial growth factor (VEGF) to the infarcted area of the heart. The hydrogel exhibited good biocompatibility, enabling the retention and integration of transplanted CMs in the host myocardium. Additionally, the delivered VEGF promoted blood recovery, mitigating the ischemic microenvironment and improving the survival of transplanted CMs. Intramyocardial injection of this hydrogel resulted in angiogenesis, inhibition of fibrosis, and improved cardiac function, highlighting its potential for MI treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Astronomy & Astrophysics
Siqi Liu, A-Li Luo, Wei Zhang, Yan-Xia Zhang, Xiao Kong, Yong-Heng Zhao
Summary: Green Pea galaxies, compact with high star formation rates, have limited H I 21 cm measurements. This study investigates the scaling relation between NUV-r color and M-H I/M-star for 38 Green Pea galaxies. The H I gas fraction of Green Pea galaxies deviates from the existing polynomial form, but follows a better prediction using linear combinations of color and other physical quantities.
RESEARCH IN ASTRONOMY AND ASTROPHYSICS
(2023)
Article
Immunology
Lingxi Liu, Yanxia Zhang, Liping Zhong
Summary: This study revealed the molecular mechanisms of the long noncoding RNA (lncRNA) TUG1 in a human renal mesangial cell (HRMC) model of lupus nephritis. The results showed that miR-153-3p directly targeted lncRNA TUG1 and its expression was increased in LPS-treated HRMCs. Transfection with TUG1-plasmid relieved LPS-induced HRMC injury, and these findings were reversed by miR-153-3p mimic. Additionally, miR-153-3p directly targeted Bcl-2 and negatively regulated its expression in HRMCs.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Nanoscience & Nanotechnology
Kunyan Lu, Yuancheng Lin, Haixin Zhang, Jingjing Cheng, Yangcui Qu, Yan Wu, Yuheng Zhang, Yi Zou, Yanxia Zhang, Qian Yu, Hong Chen
Summary: This research develops a multifunctional platform based on candle soot modification, which can efficiently deliver bioactive macromolecules into cells and nondestructively harvest engineered cells through temperature and sugar-responsive components.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Yi Zou, Haixin Zhang, Yuheng Zhang, Yan Wu, Jingjing Cheng, Dongxu Jia, Chunxia Liu, Hong Chen, Yanxia Zhang, Qian Yu
Summary: A near-infrared light-triggered nano-domino system has been proposed for efficient eradication of bacterial biofilms and promoting the healing of MRSA biofilm-infected wounds.
ACTA BIOMATERIALIA
(2023)
Review
Integrative & Complementary Medicine
Zhihao Shuai, Qionghua Xiao, Yutong Ling, Yong Zhang, Yanxia Zhang
Summary: This systematic review aimed to evaluate the efficacy of Baduanjin exercise in patients with stable chronic obstructive pulmonary disease (COPD). The results showed that Baduanjin exercise may have the potential to improve lung function, exercise capacity, health status, mental status, and quality of life in patients with stable COPD.
COMPLEMENTARY THERAPIES IN MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Yan Wu, Dongxu Jia, Kunyan Lu, Haixin Zhang, Chunxia Liu, Yuancheng Lin, Jingjing Cheng, Yi Zou, Hu Xu, Hong Chen, Yanxia Zhang, Qian Yu
Summary: A multifunctional dressing based on bacterial cellulose (BC) deposited with a tannic acid/Cu2 + ion/Mg2 + ion (TCM) complex film is developed in this study. The TCM complex exhibits robust interfacial adhesion and good photothermal properties to effectively eradicate bacteria in the wound area under near-infrared (NIR) irradiation. The released Cu2 + and Mg2 + ions from the TCM complex are favorable for endothelial cell proliferation, migration, and tube formation in vitro, promoting angiogenesis and collagen deposition in bacteria-infected wounds.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yuanyuan Wang, Jingjing Wang, Chunxia Liu, Jingjing Li, Kunyan Lu, Qian Yu, Yanxia Zhang, Zhenya Shen
Summary: An injectable composite hydrogel, composed of natural biomaterials, exosomes, and bioactive molecules, was developed to prevent or alleviate cardiac fibrosis after myocardial infarction. The encapsulation of curcumin, a natural molecule with antifibrotic activity, in exosomes derived from bone marrow-derived mesenchymal stem cells was shown to enhance its solubility and bioavailability. The composite exosomes effectively inhibited the transition of fibroblasts to myofibroblasts in vitro. The delivery of these composite exosomes using decellularized porcine cardiac extracellular matrix (dECM) hydrogel not only improved exosome retention but also provided mechanical support and structural protection. Injection of this hydrogel into a mouse myocardial infarction model resulted in decreased collagen deposition, alleviation of fibrosis, reduction of infarct size, and improvement in cardiac function. This study demonstrates the potential of the dECM hydrogel as a suitable platform for local delivery of antifibrotic biomolecule-encapsulating exosomes to prevent myocardial fibrosis and for the treatment of myocardial infarction in clinical settings.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Yinhao Jiang, Ziying Yang, Lianbo Shao, Han Shen, Xiaomei Teng, Yihuan Chen, Yinglong Ding, Jiaming Fan, You Yu, Zhenya Shen
Summary: Bone marrow stem cell (BMSC) transplantation is an innovative treatment for ischemic heart disease (IHD). Our meta-analysis shows that IHD patients with heart failure with reduced ejection fraction (HFrEF) who undergo coronary artery bypass graft (CABG) with additional BMSC transplantation can significantly improve left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), and left ventricular end-diastolic volume (LVEDV).
CELL TRANSPLANTATION
(2023)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)