Article
Biochemical Research Methods
Hsin-Yu Liao, Chin-Yi Wang, Ching-Hua Lee, Hsien-Li Kao, Wei-Kai Wu, Ching-Hua Kuo
Summary: A sensitive and effective LC-MS/MS method was developed to simultaneously quantify gut microbiota-related metabolites in human plasma. The study revealed a significant decrease in plasma butyrate levels in CVD patients, suggesting a potentially protective role in CVD.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Microbiology
Xinyue Li, Xiaochen Wang, Ziming Wang, Mingyi Zhang, Song Wang, Zuofu Xiang, Huijuan Pan, Ming Li
Summary: Gut microbiome and bile acids (BAs) are influenced by diet and play an important role in nutrient absorption in primates. Different dietary groups of primates have distinct gut microbiome communities and BA profiles. The composition of gut microbiome and the levels of BAs are related to the specific dietary adaptations of primates.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Jennifer M. Lang, Leslie R. Sedgeman, Lei Cai, Joseph D. Layne, Zhen Wang, Calvin Pan, Richard Lee, Ryan E. Temel, Aldons J. Lusis
Summary: The study indicates that high-fat diets significantly reduce gut microbiome diversity, while dietary cholesterol levels do not affect the microbiome.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Cong Liu, Zhuang Li, Zikuan Song, Xiayue Fan, Hua Shao, Milena Schonke, Mariette R. Boon, Patrick C. N. Rensen, Yanan Wang
Summary: In APOE*3-Leiden.CETP mice, neither choline nor butyrate affected the development of atherosclerosis, although both beneficially modulated the gut microbiome.
Review
Biochemistry & Molecular Biology
Giulia Gibiino, Martina De Siena, Monica Sbrancia, Cecilia Binda, Vittorio Sambri, Antonio Gasbarrini, Carlo Fabbri
Summary: Diet plays a crucial role in influencing our intestinal microbiota and ecosystem balance, but a clearly defined dietary regime to ensure its health is still lacking. The Mediterranean diet may potentially have significant benefits for our health through direct interaction with our microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Zilu Cheng, Li Zhang, Ling Yang, Huikuan Chu
Summary: Obesity is a global epidemic that significantly affects the health state of individuals and strains the socioeconomic system. The prevalence of obesity is rising at alarming rates, and its etiology involves complicated interactions of diet, genetics, and environment. The gut microbiota has been confirmed to be correlated with obesity, but the specific relationship and mechanisms are not fully understood. Altered gut microbiota and associated metabolites contribute to the progression of obesity by disrupting energy homeostasis, promoting lipid synthesis and storage, modulating central appetite and feeding behavior, as well as triggering chronic inflammation. Intentional manipulation of the gut microbiota holds promise as novel therapies for obesity, including the use of probiotics, prebiotics, and fecal microbiota transplantation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Silke Rath, Katharina Rox, Sven Kleine Bardenhorst, Ulf Schminke, Marcus Doerr, Julia Mayerle, Fabian Frost, Markus M. Lerch, Andre Karch, Mark Broenstrup, Dietmar H. Pieper, Marius Vital
Summary: The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is associated with an increased risk for cardiovascular diseases. While meat intake did not directly predict TMAO plasma levels, it was linked to TMA-forming bacteria. Additionally, advancing age was strongly associated with TMAO levels, demonstrating a functional role of gut microbiota in the aging process.
Review
Pharmacology & Pharmacy
Feng Zhu, Shudan Zheng, Mei Zhao, Fan Shi, Lihong Zheng, Haiqiang Wang
Summary: Bile acids play a crucial role in maintaining bile acid balance, intestinal barrier function, and regulating the enterohepatic circulation. Changes in intestinal microbiota composition due to cirrhosis can be related to altered bile acid composition. These changes can lead to dysbiosis of intestinal microbiota, pathogenic bacterial overgrowth, inflammation, and impairment of the intestinal barrier, which worsen the progression of cirrhosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Monica Dinu, Barbara Colombini, Giuditta Pagliai, Ilaria Giangrandi, Francesca Cesari, Annamaria Gori, Betti Giusti, Rossella Marcucci, Francesco Sofi
Summary: In a group of subjects with medium-to-low cardiovascular risk profile, a 3-month lacto-ovo-vegetarian diet resulted in significant improvements in kidney function markers, while no significant changes were observed in the Mediterranean diet group. The effects of the two diets on kidney function markers showed opposite trends. More trials are needed to confirm these results.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Dong D. Wang, Qibin Qi, Zheng Wang, Mykhaylo Usyk, Daniela Sotres-Alvarez, Josiemer Mattei, Martha Tamez, Marc D. Gellman, Martha Daviglus, Frank B. Hu, Meir J. Stampfer, Curtis Huttenhower, Rob Knight, Robert D. Burk, Robert C. Kaplan
Summary: This study reveals that adherence to the Mediterranean diet can affect gut microbiome composition and functions. The association between the Mediterranean diet and diabetes prevalence varies depending on individual gut microbial composition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Oncology
Yujing Liu, Shengan Zhang, Wenjun Zhou, Dan Hu, Hanchen Xu, Guang Ji
Summary: Colorectal cancer is a common and deadly cancer associated with inflammation. High-fat diet and overweight are linked to its incidence, with bile acids playing a crucial role in its pathogenesis. Intestinal flora also plays an important role in the development of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Nutrition & Dietetics
Ana Laffond, Cristina Rivera-Picon, Pedro Manuel Rodriguez-Munoz, Raul Juarez-Vela, Regina Ruiz de Vinaspre-Hernandez, Noelia Navas-Echazarreta, Juan Luis Sanchez-Gonzalez
Summary: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and the Mediterranean Diet (MD) may offer protection against them. Higher adherence to the MD is associated with reduced overall mortality and lower risk of CVDs. While gender differences exist, they may be influenced by lower cardiovascular risk profile in women.
Review
Nutrition & Dietetics
Alexander Pohl, Frederik Schuenemann, Kaethe Bersiner, Sebastian Gehlert
Summary: Muscular adaptations can be influenced by diet, with vegan and vegetarian diets potentially advantageous for endurance performance but disadvantageous for strength performance. Current research does not consistently show performance differences between diets, but there is a trend towards improved performance in endurance and strength exercise after vegetarian and vegan diets. Diet can modulate skeletal muscle adaptation through molecular signaling pathways involving leucine, creatine, DHA, EPA, and production of short-chain fatty acids by changing the gut microbiome.
Review
Pharmacology & Pharmacy
Kevin M. Tveter, Esther Mezhibovsky, Yue Wu, Diana E. Roopchand
Summary: Beyond their role as emulsifiers of lipophilic compounds, bile acids (BAs) are signaling endocrine molecules that show differential affinity and specificity for a variety of canonical and non-canonical BA receptors. Dysregulation of BA metabolism or signaling has emerged as a feature of chronic disease. Dietary polyphenols are associated with decreased risk of metabolic syndrome, type-2 diabetes, hepatobiliary and cardiovascular disease by altering the gut microbial community, the BA pool, and BA signaling. This review provides an overview of BA metabolism and summarizes studies linking the cardiometabolic improvements of dietary polyphenols to their modulation of BA metabolism and signaling pathways, and the gut microbiota.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Microbiology
Guillaume Dejean, Heloise Tudela, Lisa Bruno, Deborah Kissi, Georges Rawadi, Sandrine P. Claus
Summary: Christensenella minuta, a key member of the gut microbiome, was found to have a novel strain (strain DSM33407) that enhances microbiota diversity and stimulates deconjugation of primary bile acids. A protein carrying potent BSH activity was identified and cloned from the genome of C. minuta, showing preference for deconjugating glycine-conjugated bile acids. The phylogenetic tree of BSH-related enzymes in the human microbiome revealed that C. minuta's BSH sequence is distinct from others with a threshold of 70% identity.
Article
Nutrition & Dietetics
Li Wang, Ling Tao, Lei Hao, Todd H. Stanley, Kuan-Hsun Huang, Joshua D. Lambert, Penny M. Kris-Etherton
JOURNAL OF NUTRITION
(2020)
Article
Nutrition & Dietetics
Mario G. Ferruzzi, Jirayu Tanprasertsuk, Penny Kris-Etherton, Connie M. Weaver, Elizabeth J. Johnson
ADVANCES IN NUTRITION
(2020)
Article
Nutrition & Dietetics
E. A. Johnston, K. S. Petersen, P. M. Kris-Etherton
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Cardiac & Cardiovascular Systems
Jo Ann S. Carson, Alice H. Lichtenstein, Cheryl A. M. Anderson, Lawrence J. Appel, Penny M. Kris-Etherton, Katie A. Meyer, Kristina Petersen, Tamar Polonsky, Linda Van Horn
Review
Food Science & Technology
Andrew W. Brown, Kathryn A. Kaiser, Andrew Keitt, Kevin Fontaine, Madeline Gibson, Barbara A. Gower, James M. Shikany, Colby J. Vorland, Donald C. Beitz, Dennis M. Bier, J. Thomas Brenna, David R. Jacobs, Penny Kris-Etherton, Kevin Maki, Michael Miller, Marie-Pierre St-Onge, Margarita Teran-Garcia, David B. Allison
Summary: Studies have shown potential effects of dairy on cardiovascular diseases, but experts are divided on whether the intake of full-fat dairy products should be limited. Research also found variations in the dairy-CVD relationship depending on factors such as fat content, study design, and intake methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Endocrinology & Metabolism
Aesha Shah, William C. Dodson, Penny M. Kris-Etherton, Allen R. Kunselman, Christy M. Stetter, Carol L. Gnatuk, Stephanie J. Estes, Kelly C. Allison, David B. Sarwer, Patrick M. Sluss, Christos Coutifaris, Anuja Dokras, Richard S. Legro
Summary: Oral contraceptive pills have a significant impact on the hormones of patients with polycystic ovary syndrome, but this does not correlate with live birth.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Jennifer A. Fleming, Penny M. Kris-Etherton, Kristina S. Petersen, David J. Baer
Summary: Incorporating lean beef into a Mediterranean-style diet does not attenuate the reduction in lipid and lipoprotein concentrations as compared to an average American diet.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Microbiology
Zhaoyong Ba, Yujin Lee, Huicui Meng, Penny M. Kris-Etherton, Connie J. Rogers, Zachery T. Lewis, David A. Mills, Emily J. Furumoto, M. Laura Rolon, Jennifer A. Fleming, Robert F. Roberts
Summary: This study compared the effects of delivering Bifidobacterium animas subsp. lactis BB-12 through a yogurt smoothie or a capsule on healthy adults. The results showed that daily consumption of BB-12 did not significantly alter the composition of the gut microbiota, gut transit times, or fecal SCFA concentration in the study cohort.
Article
Nutrition & Dietetics
Muzi Na, Yanxiu Wang, Xinyuan Zhang, Christopher Sarpong, Penny M. Kris-Etherton, Ming Gao, Aijun Xing, Shouling Wu, Xiang Gao
Summary: The DASH dietary pattern is associated with lower nighttime blood pressure variability in elderly adults, independent of sleep parameters and other factors.
JOURNAL OF NUTRITION
(2022)
Article
Obstetrics & Gynecology
Tricia L. Hart, Kristina S. Petersen, Penny M. Kris-Etherton
Summary: A healthy eating pattern is crucial for optimal pregnancy outcomes and successful lactation. The preconception period is a critical time during which good nutrition benefits both the mother and the offspring. The presence of overweight and obesity, combined with poor nutrition, poses risks to maternal and infant health.
FERTILITY AND STERILITY
(2022)
Review
Peripheral Vascular Disease
Penny M. Kris-Etherton, Philip A. Sapp, Terrance M. Riley, Kristin M. Davis, Tricia Hart, Olivia Lawler
Summary: The recent rise in cardiovascular disease deaths in the USA has led to interest in identifying and implementing effective strategies to reverse this trend. Healthy lifestyle behaviors are crucial for CVD prevention, and even small changes can lower the risk. However, unhealthy behaviors may attenuate the effects of changing other lifestyle behaviors.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Letter
Cardiac & Cardiovascular Systems
Kamil F. Faridi, Penny M. Kris-Etherton, Karen E. Aspry
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Tricia L. Hart, Kristina S. Petersen, Penny M. Kris-Etherton
Summary: This study conducted a systematic review of the effects of cottonseed oil on lipid metabolism and found that cottonseed oil can improve lipid/lipoprotein levels compared with olive oil. The predictive equations suggest that cottonseed oil can be incorporated into a healthy dietary pattern without significantly affecting lipids/lipoproteins.
Article
Nutrition & Dietetics
Valerie K. Sullivan, Kristina S. Petersen, Victor L. Fulgoni, Fulya Eren, Martha E. Cassens, Michael T. Bunczek, Penny M. Kris-Etherton
Summary: This study found that higher quality diets are primarily distinguished by the types of fats and grain-based foods consumed, with whole fruits, seafood, and plant proteins being most favorably associated with cardiometabolic risk factors.
CURRENT DEVELOPMENTS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Kristina S. Petersen, Connie J. Rogers, Sheila G. West, David N. Proctor, Penny M. Kris-Etherton