Necroptosis: a regulated inflammatory mode of cell death

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death

(2017) Isabel Jaco et al.   MOLECULAR CELL

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

(2017) Yingying Zhang et al.   Nature Communications

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Axonal Degeneration: RIPK1 Multitasking in ALS

(2016) Kristin Politi et al.   CURRENT BIOLOGY

Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors

(2016) Andrea Barabino et al.   DEVELOPMENT

Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice

(2016) Seung‐Hoon Yang et al.   EMBO Molecular Medicine

NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration

(2016) Ishaq A. Viringipurampeer et al.   HUMAN MOLECULAR GENETICS

Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome

(2016) Kenta Moriwaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive astrocytes undergo M1 microglia/macrohpages-induced necroptosis in spinal cord injury

(2016) Hong Fan et al.   Molecular Neurodegeneration

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

Upregulation of PSMB4 is Associated with the Necroptosis after Spinal Cord Injury

(2016) Chunshuai Wu et al.   NEUROCHEMICAL RESEARCH

Neuroprotective effect of NecroX-5 against retinal degeneration in rodents

(2016) Hyung Il Kim et al.   NEUROREPORT

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

RIP1/RIP3 Binding to HSV-1 ICP6 Initiates Necroptosis to Restrict Virus Propagation in Mice

(2015) Zhe Huang et al.   Cell Host & Microbe

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing

(2015) Kenta Moriwaki et al.   JOURNAL OF IMMUNOLOGY

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

(2015) George D. Kalliolias et al.   Nature Reviews Rheumatology

Necrostatin-1 protection of dopaminergic neurons

(2015) Yan-bo Cheng et al.   Neural Regeneration Research

Oligogenic inheritance of optineurin (OPTN) andC9ORF72mutations in ALS highlights localisation of OPTN in the TDP-43-negative inclusions ofC9ORF72-ALS

(2015) Joanna J. Bury et al.   NEUROPATHOLOGY

Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury

(2015) H. Fan et al.   NEUROSCIENCE

Transcriptional dysregulation in Huntington’s disease: The role of histone deacetylases

(2015) Sorabh Sharma et al.   PHARMACOLOGICAL RESEARCH

RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality

(2015) Lingjun Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage

(2015) Kipyegon Kitur et al.   PLoS Pathogens

Diverse functions of 24(S)-hydroxycholesterol in the brain

(2014) Noriko Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner

(2014) W. W.-L. Wong et al.   BLOOD

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

(2014) X-N Wu et al.   CELL DEATH AND DIFFERENTIATION

RIPK1- and RIPK3-induced cell death mode is determined by target availability

(2014) W D Cook et al.   CELL DEATH AND DIFFERENTIATION

RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

(2014) S Orozco et al.   CELL DEATH AND DIFFERENTIATION

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis

(2014) Gaurav D. Gaiha et al.   IMMUNITY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spinal cord contusion

(2014) Gong Ju et al.   Neural Regeneration Research

Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS

(2014) Diane B. Re et al.   NEURON

Motor Neuron Death in ALS: Programmed by Astrocytes?

(2014) Sheila K. Pirooznia et al.   NEURON

Necroptosis Takes Place in Human Immunodeficiency Virus Type-1 (HIV-1)-Infected CD4+ T Lymphocytes

(2014) Ting Pan et al.   PLoS One

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

(2014) Joanne M. Hildebrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

(2014) Monica Yabal et al.   Cell Reports

The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways

(2013) Di Wang et al.   APOPTOSIS

Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis

(2013) Thomas McQuade et al.   BIOCHEMICAL JOURNAL

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

(2013) Y Dondelinger et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Combination of necroptosis and apoptosis inhibition enhances cardioprotection against myocardial ischemia–reperfusion injury

(2013) Shizuka Koshinuma et al.   Journal of Anesthesia

Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

(2013) William J. Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

(2013) S. M. Man et al.   JOURNAL OF IMMUNOLOGY

Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1  via Caspase-8 in Dendritic Cells

(2013) C. Antonopoulos et al.   JOURNAL OF IMMUNOLOGY

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains

(2013) Shan Li et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clostridium perfringens Beta-Toxin Induces Necrostatin-Inhibitable, Calpain-Dependent Necrosis in Primary Porcine Endothelial Cells

(2013) Delphine Autheman et al.   PLoS One

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis

(2013) Stephen W.G. Tait et al.   Cell Reports

A Role of RIP3-Mediated Macrophage Necrosis in Atherosclerosis Development

(2013) Juan Lin et al.   Cell Reports

Structural Insights into RIP3-Mediated Necroptotic Signaling

(2013) Tian Xie et al.   Cell Reports

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6

(2012) B J van Raam et al.   CELL DEATH AND DIFFERENTIATION

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury

(2012) Sanjoy Roychowdhury et al.   HEPATOLOGY

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

(2011) Cristina Pop et al.   BIOCHEMICAL JOURNAL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

(2009) D.-W. Zhang et al.   SCIENCE

Cytomegalovirus M45 Cell Death Suppression Requires Receptor-interacting Protein (RIP) Homotypic Interaction Motif (RHIM)-dependent Interaction with RIP1

(2008) Jason W. Upton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY