IDH1 mutation in human glioma induces chemical alterations that are amenable to optical Raman spectroscopy

Noninvasive assessment of isocitrate dehydrogenase mutation status in cerebral gliomas by magnetic resonance spectroscopy in a clinical setting

(2018) Anna Tietze et al.   JOURNAL OF NEUROSURGERY

The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis

(2017) Maarten M J Wijnenga et al.   NEURO-ONCOLOGY

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

(2017) Parker L. Sulkowski et al.   Science Translational Medicine

Clinical application of infrared fibre-optic probes for the discrimination of colorectal cancer tissues and cancer grades

(2017) Julian Ollesch et al.   VIBRATIONAL SPECTROSCOPY

Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma

(2017) Llewellyn E. Jalbert et al.   Scientific Reports

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

IDH mutations in cancer and progress toward development of targeted therapeutics

(2016) L. Dang et al.   ANNALS OF ONCOLOGY

Shining light on neurosurgery diagnostics using Raman spectroscopy

(2016) Brandy Broadbent et al.   JOURNAL OF NEURO-ONCOLOGY

The Evolving Landscape in the Development of Isocitrate Dehydrogenase Mutant Inhibitors

(2016) Jiao Chen et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Improving the accuracy of brain tumor surgery via Raman-based technology

(2016) Todd Hollon et al.   Neurosurgical Focus

Identification of regions of normal grey matter and white matter from pathologic glioblastoma and necrosis in frozen sections using Raman imaging

(2015) Rachel Kast et al.   JOURNAL OF NEURO-ONCOLOGY

Intraoperative brain cancer detection with Raman spectroscopy in humans

(2015) Michael Jermyn et al.   Science Translational Medicine

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

(2015) Elisabet Cuyàs et al.   Oncotarget

Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma

(2015) Serena Pellegatta et al.   Acta Neuropathologica Communications

Raman Spectroscopy of Biological Tissues

(2014) Abdullah Chandra Sekhar Talari et al.   APPLIED SPECTROSCOPY REVIEWS

Raman spectroscopy to distinguish grey matter, necrosis, and glioblastoma multiforme in frozen tissue sections

(2014) Steven N. Kalkanis et al.   JOURNAL OF NEURO-ONCOLOGY

A vaccine targeting mutant IDH1 induces antitumour immunity

(2014) Theresa Schumacher et al.   NATURE

Label-Free Delineation of Brain Tumors by Coherent Anti-Stokes Raman Scattering Microscopy in an Orthotopic Mouse Model and Human Glioblastoma

(2014) Ortrud Uckermann et al.   PLoS One

Assessment of Tumor Cells in a Mouse Model of Diffuse Infiltrative Glioma by Raman Spectroscopy

(2014) Kuniaki Tanahashi et al.   Biomed Research International

Hyperspectral unmixing of Raman micro-images for assessment of morphological and chemical parameters in non-dried brain tumor specimens

(2013) Norbert Bergner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

(2013) Tareq A. Juratli et al.   NEURO-ONCOLOGY

Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry

(2013) A. N. Tran et al.   NEURO-ONCOLOGY

IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection

(2013) Jason Beiko et al.   NEURO-ONCOLOGY

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Unsupervised unmixing of Raman microspectroscopic images for morphochemical analysis of non-dried brain tumor specimens

(2012) Norbert Bergner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

(2012) Masato Sasaki et al.   NATURE

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Clonal Analysis in Recurrent Astrocytic, Oligoastrocytic and Oligodendroglial Tumors Implicates IDH1- Mutation as Common Tumor Initiating Event

(2012) Ulrike Lass et al.   PLoS One

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas

(2012) A. Elkhaled et al.   Science Translational Medicine

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo

(2011) Linda B. C. Bralten et al.   ANNALS OF NEUROLOGY

IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma

(2011) Qi SongTao et al.   CANCER SCIENCE

Ex vivo and in vivo diagnosis of C6 glioblastoma development by Raman spectroscopy coupled to a microprobe

(2010) Abdelilah Beljebbar et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas

(2010) C. Houillier et al.   NEUROLOGY

Fiber-optic probes enable cancer detection with FTIR spectroscopy

(2010) Mark A. Mackanos et al.   TRENDS IN BIOTECHNOLOGY

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA