Article
Geriatrics & Gerontology
John P. Haran, Abigail Zeamer, Doyle Ward, Protiva Dutta, Vanni Bucci, Beth A. McCormick
Summary: The gut microbiome of older adults in nursing homes is heavily influenced by medications, age, and frailty. Dysbiosis becomes evident after 12 months of residency, but there is relative stability over time beyond that point.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Yiyang Yuan, Kate L. Lapane, Jennifer Tjia, Jonggyu Baek, Shao-Hsien Liu, Christine M. Ulbricht
Summary: The study identified three physical frailty subgroups in older nursing home residents: mild, moderate, and severe. Those with moderate or severe physical frailty were more likely to have cognitive impairment and need assistance in daily activities. The findings suggest a complex interplay between physical frailty and cognitive impairment in this population.
Article
Geriatrics & Gerontology
Sarah Damanti, Philipe de Souto Barreto, Yves Rolland, Paolo Astrone, Matteo Cesari
Summary: The study found that higher MNA-SF scores were associated with better physical performance, particularly gait speed. Factors such as food intake deficiency, mobility impairment, and recent psychological stress or acute disease were found to be most related to SPPB. In nursing home residents, MNA-SF and three of its sub-items were significantly correlated with physical performance, specifically with the gait speed subtask of the SPPB.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Domenico Azzolino, Emanuele Marzetti, Marco Proietti, Riccardo Calvani, Philipe de Souto Barreto, Yves Rolland, Matteo Cesari
Summary: The study found a close association between lack of energy and malnutrition among nursing home residents. Reporting lack of energy should prompt a comprehensive assessment of the aging individual to address potentially reversible causes.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Nutrition & Dietetics
Yu-Mi Kim, Narae Yang, Kirang Kim
Summary: This study found that the perceived food store environment in the local community can significantly influence the occurrence of malnutrition and frailty in vulnerable, urban older adults.Factors such as food store sufficiency, freshness of foods, variety in foods, and small purchase of foods were identified as significant factors affecting the risk of malnutrition and frailty.
Article
Geriatrics & Gerontology
Sin Yee Chew
Summary: This study aimed to investigate the prevalence of loneliness among nursing home residents in Singapore and its associations with variables such as health statuses and social contacts. The results showed that approximately 60% of nursing home residents experienced loneliness, with significant associations found between frailty and loneliness, and history of falls and loneliness.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2022)
Article
Endocrinology & Metabolism
Andrew R. Zullo, Matthew S. Duprey, Robert J. Smith, Roee Gutman, Sarah D. Berry, Medha N. Munshi, David D. Dore
Summary: This study evaluated the effects of DPP4Is versus SUs on cognitive and physical functioning in nursing home residents. Results showed that DPP4I users had lower rates of cognitive and functional decline within 180 days, but the estimates were imprecise, calling for larger studies to provide more precise effect estimates.
DIABETES OBESITY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Wojciech Tanski, Justyna Wojciga, Beata Jankowska-Polanska
Summary: Rheumatoid arthritis is a progressive joint disease that can affect multiple organs in addition to causing joint damage. Elderly patients with RA often experience pain, fatigue, mood disorders, and other complications, which can significantly impact their quality of life. Malnutrition can worsen frailty, cognitive function, and daily functioning in these patients. Frailty is a major factor contributing to poorer quality of life in elderly RA patients.
Article
Health Care Sciences & Services
Aurelio Lo Buglio, Francesco Bellanti, Cristiano Capurso, Gianluigi Vendemiale
Summary: The Controlling Nutritional Status (CONUT) score is a simple screening tool that can detect nutritional status and predict adverse clinical outcomes in specific populations. This study aimed to investigate the predictive role of the CONUT score on mortality and length of stay (LOS) in frail patients admitted to an Internal Medicine Department. The results showed that high CONUT scores were associated with longer LOS, but did not significantly predict mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nutrition & Dietetics
Lijuan Wang, Pengxue Li, Yifu Hu, Bo Cheng, Lili Ding, Lei Li, Jinghai Song, Junmin Wei, Jingyong Xu
Summary: This study analyzed the correlation between preoperative nutritional status, frailty, sarcopenia, body composition, and anthropometry in geriatric inpatients undergoing major pancreatic and biliary surgery. The study found a high prevalence and overlap rates of malnutrition, frailty, and sarcopenia in elderly inpatients, with body composition and function deteriorating with aging. Age and malignancy affected the nutrition diagnosis.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Che-Yu Lee, Jiun-Rong Chen, Min-Yu Ding, Feng-Qi Liang, Suh-Ching Yang
Summary: The purpose of this study was to compare the effects of nutritional supplement drinks (NSDs) and nutritional education (NE) on the nutritional status and physical performance of older nursing home residents who were at risk of malnutrition. After 12 weeks of NE combined with NSD intervention, improvements were observed in body weight, body-mass index, mini nutritional assessment-short form (MNA-SF) score, walking speed, and SF-36 questionnaire score in older nursing home residents at risk of malnutrition.
Article
Geriatrics & Gerontology
Andrew R. R. Zullo, Melissa R. R. Riester, Kaleen N. N. Hayes, Medha N. N. Munshi, Sarah D. D. Berry
Summary: We compared the effects of three sulfonylureas (SUs) and initial SUs doses on adverse glycemic and cardiovascular events among nursing home residents. Our findings suggest that new use of glimepiride and standard SU doses may increase the risk of severe hypoglycemic events, while cardiovascular outcomes may not be affected by the choice of SU medication or dose.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Gulistan Bahat, B. Ilhan, A. Tufan, H. Dogan, M. A. Karan
Summary: The study found that a simplified modified Fried frailty scale can predict mortality among nursing home residents. Results suggest that frailty is an independent predictor of death, even after adjusting for other factors.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Nutrition & Dietetics
Mathuramat Seesen, Wachiranun Sirikul, Jetsada Ruangsuriya, Jiranan Griffiths, Penprapa Siviroj
Summary: The study found a correlation between malnutrition and cognitive frailty among Thai elderly, with MNA-SF category and score being independently associated factors, while serum prealbumin level and anthropometric measurements showed no correlation with cognitive frailty. Advanced age and low educational level were also identified as risk factors for cognitive frailty.
Article
Nutrition & Dietetics
Selma Cvijetic, Irena Keser, Dario Boschiero, Jasminka Z. Ilich
Summary: The aim of this study was to evaluate body composition and prevalence of osteosarcopenic adiposity (OSA) in nursing home residents (NHR) and to assess their nutritional status. The findings revealed a high prevalence of OSA and poor nutritional status in the NHR population. The study also showed a strong association between osteosarcopenic adiposity and malnutrition/risk of malnutrition in this population.
Article
Multidisciplinary Sciences
Takeshi Tanoue, Satoru Morita, Damian R. Plichta, Ashwin N. Skelly, Wataru Suda, Yuki Sugiura, Seiko Narushima, Hera Vlamakis, Iori Motoo, Kayoko Sugita, Atsushi Shiota, Kozue Takeshita, Keiko Yasuma-Mitobe, Dieter Riethmacher, Tsuneyasu Kaisho, Jason M. Norman, Daniel Mucida, Makoto Suematsu, Tomonori Yaguchi, Vanni Bucci, Takashi Inoue, Yutaka Kawakami, Bernat Olle, Bruce Roberts, Masahira Hattori, Ramnik J. Xavier, Koji Atarashi, Kenya Honda
Article
Microbiology
John P. Haran, Shakti K. Bhattarai, Sage E. Foley, Protiva Dutta, Doyle V. Ward, Vanni Bucci, Beth A. McCormick
Article
Hematology
Matthew S. Kelly, Doyle V. Ward, Christopher J. Severyn, Mehreen Arshad, Sarah M. Heston, Kirsten Jenkins, Paul L. Martin, Lauren McGill, Andre Stokhuyzen, Shakti K. Bhattarai, Vanni Bucci, Patrick C. Seed
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2019)
Review
Engineering, Environmental
Ferdi L. Hellweger, Carsten Vick, Fiona Rueckbeil, Vanni Bucci
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Chemistry, Medicinal
Jacob D. Palmer, Benedikt M. Mortzfeld, Emma Piattelli, Mark W. Silby, Beth A. McCormick, Vanni Bucci
ACS INFECTIOUS DISEASES
(2020)
Article
Hematology
John Tanaka, Rebecca Young, Sarah M. Heston, Kirsten Jenkins, Lisa Spees, Anthony D. Sung, Kelly Corbet, Jillian C. Thompson, Lauren Bohannon, Paul L. Martin, Andre Stokhuyzen, Richard Vinesett, Doyle Ward, Shakti K. Bhattarai, Vanni Bucci, Mehreen Arshad, Patrick C. Seed, Matthew S. Kelly
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2020)
Article
Gastroenterology & Hepatology
John P. Haran, Beth A. McCormick
Summary: The human gut microbiome, consisting of bacteria, protozoa, fungi, and viruses, plays essential roles in protecting, metabolizing, and maintaining human health. Imbalances within the intestinal microbial community structure are increasingly recognized as being involved in disease processes across various organ systems, particularly due to untoward inflammatory responses. Recent advances in understanding the microbiome's role in aging have opened the door for potential novel therapeutics targeting a less dysbiotic microbiome to prevent or treat age-related diseases.
Letter
Medicine, Research & Experimental
John P. Haran, Jose C. Pinero, Yan Zheng, Norma Alonzo Palma, Mark Wingertzahn
Summary: The two parallel studies aim to evaluate the safety and impact of KB109 in addition to supportive self-care compared to self-care alone in outpatients with mild to moderate COVID-19. These studies also assess the effect of KB109 on gut microbiota and various health indicators in patients receiving different treatment regimens.
Article
Medicine, Research & Experimental
John P. Haran, Evan Bradley, Abigail L. Zeamer, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Mario Meza-Segura, Ann M. Moormann, Doyle Ward, Beth A. McCormick, Vanni Bucci
Summary: In a study, it was found that patients with long COVID had higher abundance of bacteria in the oral microbiome that can induce inflammation, such as Prevotella and Veillonella genera. These microbes may be related to the development of ongoing symptoms in patients, and the oral microbiome of long COVID patients resembled that of patients with chronic fatigue syndrome.
Article
Cell Biology
Catherine C. Neto, Benedikt M. Mortzfeld, John R. Turbitt, Shakti K. Bhattarai, Vladimir Yeliseyev, Nicholas DiBenedetto, Lynn Bry, Vanni Bucci
Summary: Cranberry consumption has health benefits including anti-inflammatory and anti-tumor properties. Research suggests that the effects of cranberry on health could be related to its ability to modulate the microbiome, but more studies are needed to investigate the impact, especially regarding PACs. The study on the short-term dynamics of a human-derived bacterial community after a PAC-rich cranberry juice extract intervention showed distinct dynamic patterns in bacterial abundances, indicating that termination of the intervention can induce significant changes in the microbiota.
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Article
Gastroenterology & Hepatology
Benedikt M. Mortzfeld, Jacob D. Palmer, Shakti K. Bhattarai, Haley L. Dupre, Regino Mercado-Lubio, Mark W. Silby, Corinna Bang, Beth A. McCormick, Vanni Bucci
Summary: This study discovered a potent antimicrobial called MccI47 against specific drug-resistant bacteria. The researchers genetically modified the probiotic Escherichia coli bacterium to produce MccI47, and demonstrated that the engineered strain significantly reduced the abundance of carbapenem-resistant Klebsiella pneumoniae in a clinical model without disrupting the resident microbiota. This study lays the foundation for using engineered live biotherapeutic products to selectively remove multidrug-resistant pathogens from the gastrointestinal tract.
Article
Microbiology
Vanni Bucci, Doyle V. Ward, Shakti Bhattarai, Mayra Rojas-Correa, Ayan Purkayastha, Devon Holler, Ming Da Qu, William G. Mitchell, Jason Yang, Samuel Fountain, Abigail Zeamer, Catherine S. Forconi, Gavin Fujimori, Boaz Odwar, Caitlin Cawley, Ann M. Moormann, Mireya Wessolossky, Ana Maldonado-Contreras
Summary: SARS-CoV-2-positive patients exhibit gut and oral microbiome dysbiosis, which is associated with various aspects of COVID-19 disease. Gut microbiota, but not oral microbiota, is a reliable predictor of both COVID-19-related fatality and severity in hospitalized patients, with a higher predictive value than most clinical variables. Perturbations of the gut microbiota due to enteral feeding do not associate with species that were predictive of COVID-19 severity.
Article
Gastroenterology & Hepatology
John P. Haran, Doyle V. Ward, Shakti K. Bhattarai, Ethan Loew, Protiva Dutta, Amanda Higgins, Beth A. McCormick, Vanni Bucci
Summary: C. difficile is prevalent among elderly living in nursing homes, with dysbiotic gut microbiome being associated with its colonization. The use of proton pump inhibitors is linked to a lower prevalence of C. difficile.
Article
Microbiology
Tyler Rommeel, Kazuhiko Kurosawa, Lucy M. McCully, Mark W. Silby, Vanni Bucci, Christopher J. Brigham
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)