Article
Gastroenterology & Hepatology
Lusheng Song, Minkyo Song, Charles S. Rabkin, Yunro Chung, Stacy Williams, Javier Torres, Alejandro H. Corvalan, Robinson Gonzalez, Enrique Bellolio, Mahasish Shome, Joshua LaBaer, Ji Qiu, M. Constanza Camargo
Summary: Our study provides a comprehensive assessment of anti-H. pylori antibody profiles in gastric intestinal metaplasia (IM). The identified novel antibodies against target antigens, in addition to CagA, may play a role in the progression of IM. Specific H. pylori antibodies, along with other biomarkers, can help identify IM patients for surveillance.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Xinhua Liang, Wenjun Du, Ling Huang, Li Xiang, Wenxu Pan, Fangying Yang, Fengfeng Zheng, Yongwu Xie, Lanlan Geng, Sitang Gong, Wanfu Xu
Summary: This study found that Helicobacter pylori promotes gastric intestinal metaplasia through the kynurenine pathway of tryptophan metabolism, which activates CDX2 gene expression in gastric epithelial cells. Inhibition of kynurenine aminotransferase II (KAT2) activity can reverse the effect of H. pylori on CDX2 expression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Gastroenterology & Hepatology
Yongqiang Liang, Yuanhai Yang, Ruiheng Nong, Hao Huang, Xiuyun Chen, Ying Deng, Zhicong Huang, Jingyao Huang, Chunsheng Cheng, Mingzhu Ji, Yinggang Chen, Fulan Hu
Summary: H. pylori eradication significantly improves atrophic gastritis (AG) and intestinal metaplasia (IM) at an early stage. Various factors such as study design, lesion sites, regions, and follow-up time are important in determining this association.
Review
Cell Biology
Jose Jessurun
Summary: This article focuses on the various aspects of infection that challenge the universality of medical implications through the application of evolutionary science to medicine. It discusses the divergent epidemiological and clinical outcomes observed in different populations, as well as the potential beneficial aspects of the infection. The article also reviews Correa's seminal contributions to the understanding of gastric cancer and postinflammatory tumors, along with the renewed interest in intestinal metaplasia and its clinical implications.
Article
Immunology
Samaneh Saberi, Maryam Esmaeili, Mohammad Tashakoripour, Mahmoud Eshagh Hosseini, Hossein Baharvand, Marjan Mohammadi
Summary: This study evaluated the expression patterns of candidate genes induced by H. pylori infection and found that it caused regulatory changes in genes related to gastric-to-intestinal transdifferentiation. These changes included upregulation of self-renewal and pluripotency factors and aberrant expression of intestine-specific transcription factors, further promoting the process of transdifferentiation. These findings may contribute to a better understanding of the mechanism of gastric-to-intestinal transdifferentiation.
MICROBIAL PATHOGENESIS
(2022)
Article
Medicine, General & Internal
Lina Feng, Mingyu Zhang, Jialun Guan, Yu Zhang, Yujie Huang, Ruonan Dong, Kai Zhao, Suhong Xia, Fang Xiao, Jiazhi Liao
Summary: A retrospective study found that esophageal/duodenal xanthelasma may not be associated with upper gastrointestinal diseases, but gastric xanthelasma (GX) is related to atrophic gastritis, intestinal metaplasia, gastric cancer, and H.pylori infection, especially multiple GXs which may serve as easily detectable warning signs for these diseases.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Hsuan Hsieh, Hsiao-Bai Yang, Bor-Shyang Sheu, Yao-Jong Yang
Summary: This study aimed to evaluate the histopathological pattern of H. pylori atrophic gastritis in children and the extent of precancerous lesions. The results showed that the prevalence rates of gastric glandular atrophy, intestinal metaplasia, and spasmolytic peptide-expressing metaplasia (SPEM) in children with H. pylori infection were 30.4%, 4.3%, and 8.7% respectively. SPEM and high-grade atrophy were more common in female patients.
Article
Psychiatry
Hector Cabello-Rangel, Marisol Basurto-Morales, Elizabeth Botello-Aceves, Osiris Pazaran-Galicia
Summary: This study described the differences in mean platelet volume (MPV), platelet count, and neutrophil/lymphocyte ratio (NLR) between patients with schizophrenia and healthy controls, and examined their correlation with the duration of untreated psychosis (DUP). The results showed that patients with schizophrenia had higher MPV levels than healthy controls, but the difference was not statistically significant. Additionally, DUP did not have a significant correlation with the blood parameters analyzed.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Gastroenterology & Hepatology
Massimo Rugge, Ludovica Bricca, Stefano Guzzinati, Diana Sacchi, Marco Pizzi, Edoardo Savarino, Fabio Farinati, Manuel Zorzi, Matteo Fassan, Angelo Paolo Dei Tos, Peter Malfertheiner, Robert M. Genta, David Y. Graham
Summary: The study found that autoimmune gastritis (AIG) patients exhibit oxyntic-predominant-mononuclear inflammation, PPM (more than IM), and ECL-cell hyperplasia/neoplasia as histological hallmarks. Over a cumulative follow-up time of 10,541 person years, there was no excess risk of gastric or other malignancies found, except for a (marginally significant) risk of thyroid cancer.
Article
Microbiology
V. P. O'Brien, L. K. Jackson, J. P. Frick, A. E. Rodriguez Martinez, D. S. Jones, C. D. Johnston, N. R. Salama
Summary: Chronic infection with Helicobacter pylori is the primary risk factor for developing stomach cancer. In a transgenic mouse gastric metaplasia model, H. pylori strains from unrelated individuals differed in their ability to infect the stomach and colonize metaplastic glands. Genetic variation in a cell surface adhesin gene called sabB was associated with the ability to colonize the diseased stomach environment.
Article
Gastroenterology & Hepatology
Young Jae Hwang, Yonghoon Choi, Nayoung Kim, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
Summary: The study found that both endoscopic and histologic improvements of atrophic gastritis and intestinal metaplasia were observed after H. pylori eradication, with endoscopic improvement taking significantly longer time than histologic improvement.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Hong-Yan Chen, Yi Hu, Xin-Bo Xu, Yan-An Zhou, Nian-Shuang Li, Cong He, Chuan Xie, Nong-Hua Lu, Yin Zhu
Summary: The study revealed that H. pylori infection increases ACVR1 expression, promoting gastric intestinal metaplasia by regulating CDX2, which is a crucial step in H. pylori carcinogenesis.
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Biochemistry & Molecular Biology
Muhammad Miftahussurur, Ricky Indra Alfaray, Kartika Afrida Fauzia, Astri Dewayani, Dalla Doohan, Langgeng Agung Waskito, Yudith Annisa Ayu Rezkitha, Didik Huswo Utomo, Gde Somayana, Ari Fahrial Syam, Masrul Lubis, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka
Summary: In this study, the expression of genes encoding proinflammatory cytokines in gastric biopsy specimens was analyzed to understand the low incidence of intestinal metaplasia in Indonesia. The characteristics of East-Asian-type CagA in Indonesia were also investigated. The findings suggest that both the low inflammatory response of the host and the lower virulence of CagA play a role in the low incidence of intestinal metaplasia in Indonesia.
Article
Oncology
Kazuyo Kaneko, Abed M. Zaitoun, Darren P. Letley, Joanne L. Rhead, Javier Torres, Ian Spendlove, John C. Atherton, Karen Robinson
Summary: The study found that CD55 expression levels significantly increased in Helicobacter pylori-infected patients and were associated with intestinal metaplasia (IM), but not with gastric atrophy or inflammation. Infection with vacA i1-type strains was linked to increased gastric CD55 expression and IM.
JOURNAL OF PATHOLOGY
(2022)