Article
Immunology
Hanne Beeckmans, Gene P. L. Ambrocio, Saskia Bos, Astrid Vermaut, Vincent Geudens, Arno Vanstapel, Bart M. Vanaudenaerde, Frans De Baets, Thomas L. A. Malfait, Marie-Paule Emonds, Dirk E. Van Raemdonck, Helene M. Schoemans, Robin Vos, Leuven Lung Transplant Grp
Summary: Pulmonary alveolar proteinosis (PAP) is a rare lung disorder characterized by surfactant accumulation, and lung transplantation followed by hematopoietic stem cell transplantation may be an effective treatment for end-stage hereditary PAP-induced pulmonary fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Izabella Skulimowska, Justyna Sosniak, Monika Gonka, Agata Szade, Alicja Jozkowicz, Krzysztof Szade
Summary: Recent studies on hematopoietic stem cells (HSCs) have shown promising opportunities and challenges for their clinical applications. The heterogenic pool of HSCs dynamically changes with aging, involving complex interactions with the bone marrow niche. These findings may lead to overcoming current limitations in HSC transplantation and expanding the patient group that can benefit from the clinical potential of HSCs.
Article
Oncology
Elena Kum, Gabriele Jagelaviciute, Edward Li, Kenneth Williams, Santhosh Thyagu, Warren Fingrut
Summary: The article tells the story of a Canadian stem cell recipient who underwent transplantation from a matched unrelated donor for refractory chronic myelogenous leukemia, showcasing different perspectives and encouraging people to become donors.
Review
Nutrition & Dietetics
Siyuan Sun, Yingxue Han, Yumei Lei, Yifei Yu, Yanbin Dong, Juan Chen
Summary: This review comprehensively summarizes the intrinsic factors involved in the regulation of hematopoietic stem cells (HSCs), including RNA-binding protein, modulators in epigenetics, and enhancer-promotor-mediated transcription. It also explores their roles in bone marrow transplantation therapies and autoimmune diseases. Additionally, it discusses the effects of high-fat diets and nutrients (such as vitamins, amino acids, probiotics, and prebiotics) on HSC regulation, providing valuable insights for future HSC research.
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Yan Man, Zhixiang Lu, Xiangmei Yao, Yuemin Gong, Tonghua Yang, Yajie Wang
Summary: PGF is a life-threatening complication that occurs after transplantation and predicting and preventing it remains challenging. This study finds that CD34(+) cells, bone marrow microenvironment, and factors like viral infection and iron overload are closely related to the occurrence of PGF. The article summarizes the common risk factors and potential mechanism of PGF, as well as discusses the safety and efficacy of new strategies for treating it.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Shiela McCollam, James S. Lewis, Joseph Bubalo, Amber Diaz
Summary: This study aimed to evaluate the efficacy and safety of 300-mg once-monthly intravenous (IV) pentamidine prophylaxis in 702 adult allogeneic hematopoietic stem cell transplant (HSCT) patients. The results showed that IV pentamidine administration effectively prevented Pneumocystis jirovecii pneumonia (PJP), but breakthrough Nocardia and Toxoplasma infections were observed in a certain percentage of patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Laura Breda, Tyler E. Papp, Michael P. Triebwasser, Amir Yadegari, Megan T. Fedorky, Naoto Tanaka, Osheiza Abdulmalik, Giulia Pavani, Yongping Wang, Stephan A. Grupp, Stella T. Chou, Houping Ni, Barbara L. Mui, Ying K. Tam, Drew Weissman, Stefano Rivella, Hamideh Parhiz
Summary: This study developed a nanoparticle system that can target hematopoietic stem cells in vivo and achieved correction of diseased cells through mRNA delivery. Furthermore, this system enables non-genotoxic conditioning for stem cells, providing a new approach for HSCT.
Article
Allergy
Rebecca A. Marsh, Kyle Hebert, Soyoung Kim, Christopher C. Dvorak, Victor M. Aquino, K. Scott Baker, Deepak Chellapandian, Blachy Davila Saldana, Christine N. Duncan, Michael J. Eckrich, George E. Georges, Timothy S. Olson, Michael A. Pulsipher, Shalini Shenoy, Elizabeth Stenger, Mark Vander Lugt, Lolie C. Yu, Andrew R. Gennery, Mary Eapen
Summary: Allogeneic hematopoietic cell transplantation for hemophagocytic lymphohistiocytosis (HLH) disorders is associated with substantial morbidity and mortality. The study found that conditioning regimens using flu/melphalan and flu/melphalan/thiotepa had better outcomes compared to other regimens in terms of post-transplant complications and survival rates in HLH patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Cell Biology
Julia Froebel, Theresa Landspersky, Guelce Percin, Christina Schreck, Susann Rahmig, Alessandro Ori, Daniel Nowak, Marieke Essers, Claudia Waskow, Robert A. J. Oostendorp
Summary: The bone marrow environment, known as the niche, plays a vital role in maintaining blood cell formation throughout life. Different types of stress can disrupt the niche, leading to deregulation of hematopoietic stem cells and their function. Both acute and chronic insults can alter the cellular composition and structure of the niche, ultimately affecting hematopoiesis and increasing susceptibility to diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Elad Jacoby, Omer Bar-Yosef, Noah Gruber, Einat Lahav, Nira Varda-Bloom, Yoav Bolkier, Diana Bar, Moriya Ben-Yakir Blumkin, Sharon Barak, Etzyona Eisenstein, Jaana Ahonniska-Assa, Tamar Silberg, Tal Krasovsky, Orly Bar, Neta Erez, Bella Bielorai, Hana Golan, Benjamin Dekel, Michal J. Besser, Gat Pozner, Hanan Khoury, Alan Jacobs, John Campbell, Eli Herskovitz, Noa Sher, Natalie Yivgi-Ohana, Yair Anikster, Amos Toren
Summary: This study developed a method to treat patients with mtDNA disorders by enriching hematopoietic cells with exogenous mitochondria. The treatment showed promising results in improving the patients' condition, including reducing heteroplasmy and increasing mtDNA content. This lays the foundation for future clinical trials of mitochondrial augmentation therapy (MAT).
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Cell & Tissue Engineering
Tomoya Terashima, Miwako Katagi, Natsuko Ohashi
Summary: Diabetic neuropathy is a significant complication of diabetes mellitus that is associated with hyperglycemia. Despite glycemic control, neuropathy continues to progress slowly. The involvement of bone marrow-derived cells (BMDCs) in the pathogenesis of diabetic neuropathy has been reported, with cell fusion leading to neuronal dysfunction and apoptosis. This finding provides new directions for therapeutic methods and understanding the irreversibility of diabetic neuropathy.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Cornelia Lee-Thedieck, Peter Schertl, Gerd Klein
Summary: This review provides a comprehensive overview of the extracellular matrix (ECM) in hematopoietic stem cell (HSC) niches and highlights its importance in regulating cellular function and niche structure. The role of different classes of ECM molecules and their interactions with cells are discussed, along with the significance of matrix remodeling and biophysics in HSC niche function. The review also examines the application of current knowledge of ECM in artificial HSC niches for HSC expansion, targeted differentiation, and drug testing.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Lisa Gross, Dirk Sibbing, Christian Schulz, Florian Gaertner, Joachim Pircher, Steffen Massberg, Tobias Petzold
CLINICAL RESEARCH IN CARDIOLOGY
(2018)
Article
Multidisciplinary Sciences
Julia Novotny, Sue Chandraratne, Tobias Weinberger, Vanessa Philippi, Konstantin Stark, Andreas Ehrlich, Joachim Pircher, Ildiko Konrad, Paul Oberdieck, Anna Titova, Qendresa Hoti, Irene Schubert, Kyle R. Legate, Nicole Urtz, Michael Lorenz, Jaroslav Pelisek, Steffen Massberg, Marie-Luise von Bruehl, Christian Schulz
Article
Multidisciplinary Sciences
Joachim Pircher, Thomas Czermak, Andreas Ehrlich, Clemens Eberle, Erik Gaitzsch, Andreas Margraf, Jochen Grommes, Prakash Saha, Anna Titova, Hellen Ishikawa-Ankerhold, Konstantin Stark, Tobias Petzold, Thomas Stocker, Ludwig T. Weckbach, Julia Novotny, Markus Sperandio, Bernhard Nieswandt, Alberto Smith, Hanna Mannell, Barbara Walzog, David Horst, Oliver Soehnlein, Steffen Massberg, Christian Schulz
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
Elisa Gomez Perdiguero, Christian Schulz, Frederic Geissmann
Review
Cell Biology
Andreas Meinhardt, Ming Wang, Christian Schulz, Sudhanshu Bhushan
JOURNAL OF LEUKOCYTE BIOLOGY
(2018)
Article
Hematology
Christian Schulz, Ulrich H. Von Andrian, Steffen Massberg
Article
Hematology
Thomas J. Stocker, Joachim Pircher, Artid Skenderi, Andreas Ehrlich, Clemens Eberle, Remco T. A. Megens, Tobias Petzold, Zhe Zhang, Barbara Walzog, Annette Mueller-Taubenberger, Christian Weber, Steffen Massberg, Hellen Ishikawa-Ankerhold, Christian Schulz
THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Hematology
Christian Schulz, Olga von Beckerath, Rainer Okrojek, Nicolas von Beckerath, Steffen Massberg
THROMBOSIS JOURNAL
(2010)
Article
Hematology
Christian Schulz, Ildiko Konrad, Susanne Sauer, Lena Orschiedt, Maria Koellnberger, Reinhard Lorenz, Ulrich Walter, Steffen Massberg
THROMBOSIS AND HAEMOSTASIS
(2008)
Article
Hematology
Andreas Schaefer, Christian Schulz, Daniela Fraccarollo, Piet Tas, Meike Leutke, Martin Eigenthaler, Stefan Seidl, Peter Heider, Georg Ertl, Steffen Massberg, Johann Bauersachs
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2007)
Article
Hematology
S Massberg, S Gruner, I Konrad, MIG Arguinzonis, M Eigenthaler, K Hemler, J Kersting, C Schulz, I Muller, F Besta, B Nieswandt, U Heinzmann, U Walter, M Gawaz