Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cell Biology
Sabrina Quaresima, Arif Istiaq, Hirofumi Jono, Emanuele Cacci, Kunimasa Ohta, Giuseppe Lupo
Summary: This article reviews recent advances in the study of the complex interactions between V-SVZ NSCs and their cellular niche. The focus is on the extracellular cues produced by ependymal and vascular cells that regulate NSC behavior in the mouse postnatal V-SVZ, and the potential implications of these molecular signals in pathological conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
He Wang, Mengmeng Xing, Weiliang Deng, Meng Qian, Fei Wang, Kai Wang, Adam C. Midgley, Qiang Zhao
Summary: By immobilizing stem cell antigen-1 (Sca-1) antibody, the vascular graft can promote the role of vascular stem/progenitor cells (SPCs) in vascular regeneration and induce rapid vascular regeneration from local tissues and bone marrow.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Kimberly J. Berry, Uma Chandran, Fangping Mu, Dinesh K. Deochand, T. Lei, Miriam Pagin, Silvia K. Nicolis, A. Paula Monaghan-Nichols, Inez Rogatsky, Donald B. DeFranco
Summary: Prenatal exposure to synthetic glucocorticoids (sGCs) can reprogram brain development and increase the risk of adverse neurodevelopmental outcomes in the fetus. In a mouse model, researchers found that sGCs caused sexually dimorphic changes in the transcriptome of neural stem and progenitor cells (NSPCs) in the embryonic brain. By analyzing multiple genome-wide assays, they discovered that glucocorticoid receptor (GR) preferentially binds to specific regions of accessible chromatin to influence gene programming and cell fate decisions in NSPCs. They also identified SOX2 as a transcription factor that affects the genomic response of certain GR target genes to sGCs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Cell Biology
Jose Manuel Inacio, Joao von Gilsa Lopes, Ana Mafalda Silva, Fernando Cristo, Sara Marques, Matthias E. Futschik, Jose Antonio Belo
Summary: Deciphering the clues of a regenerative mechanism for the mammalian adult heart, particularly focusing on the role of DAND5, could potentially lead to the development of more effective treatment options for heart failure. Further research on the transcriptional profiling sequencing and quantitative RT-PCR assays of DAND5 may provide insights into the generation and expansion of pluripotent stem cell-derived cardiomyocytes systems for clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiexiang Zhao, Ping Lu, Cong Wan, Yaping Huang, Manman Cui, Xinyan Yang, Yuqiong Hu, Yi Zheng, Ji Dong, Mei Wang, Shu Zhang, Zhaoting Liu, Shuhui Bian, Xiaoman Wang, Rui Wang, Shaofang Ren, Dazhuang Wang, Zhaokai Yao, Gang Chang, Fuchou Tang, Xiao-Yang Zhao
Summary: Through single-cell sequencing, the study investigates the transcriptome landscapes of mouse male germ cells throughout development and identifies critical regulators for prenatal cell-fate determination.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Diego Herrero, Guillermo Albericio, Marina Higuera, Maria Herranz-Lopez, Miguel A. Garcia-Brenes, Alejandra Cordero, Enrique Roche, Pilar Sepulveda, Carmen Mora, Antonio Bernad
Summary: Research on the interaction of adult cardiac progenitor cells with other cardiac cell populations can define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and manipulating this niche may offer new hope in the cardiac regeneration field.
Article
Multidisciplinary Sciences
Rhonda L. Mcfleder, Anastasiia Makhotkina, Janos Groh, Ursula Keber, Fabian Imdahl, Josefina Pena Mosca, Alina Peteranderl, Jingjing Wu, Sawako Tabuchi, Jan Hoffmann, Ann-Kathrin Karl, Axel Pagenstecher, Jorg Vogel, Andreas Beilhack, James B. Koprich, Jonathan M. Brotchie, Antoine-Emmanuel Saliba, Jens Volkmann, Chi Wang Ip
Summary: Inflammation in the brain and gut plays a crucial role in neurological diseases like Parkinson's disease (PD). The aggregation of the pre-synaptic protein, alpha-synuclein (alpha Syn), triggers the immune system in PD. Understanding how alpha Syn aggregates spread between the brain and gut is important for developing treatments for the disease.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Lingyan Fang, Takaaki Kuniya, Yujin Harada, Osamu Yasuda, Nobuyo Maeda, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh
Summary: Adult neural stem cells (NSCs) in the mouse subventricular zone (SVZ) arise from a slowly dividing subpopulation of embryonic neural stem-progenitor cells (NPCs). The maintenance of these slowly dividing embryonic NPCs until adulthood and their role in the establishment of adult NSCs is poorly understood. This study explores the potential involvement of tissue inhibitors of metalloproteinases (TIMPs), regulators of extracellular matrix (ECM) remodeling, in the establishment and maintenance of adult NSCs. The findings suggest that TIMP3 plays a crucial role in maintaining the undifferentiated state of embryonic NPCs, leading to the establishment and maintenance of adult NSCs.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell & Tissue Engineering
Naoya Yuizumi, Yujin Harada, Takaaki Kuniya, Takehiko Sunabori, Masato Koike, Masaki Wakabayashi, Yasushi Ishihama, Yutaka Suzuki, Daichi Kawaguchi, Yukiko Gotoh
Summary: Lysosomes play a crucial role in regulating the differentiation of neural stem-progenitor cells in the embryonic brain, with TFEB and TFE3 potentially maintaining the undifferentiated state of NPCs through controlling lysosomal biosynthesis. The abundance of lysosomes is associated with cell division activity and the embryonic origin of adult NSCs. TFEB-AA overexpression suppresses neuronal differentiation and the cell cycle of neocortical NPCs.
Article
Medicine, Research & Experimental
Dan Huang, Guohuan Sun, Xiaoxin Hao, Xiaoxiao He, Zhaofeng Zheng, Chiqi Chen, Zhuo Yu, Li Xie, Shihui Ma, Ligen Liu, Bo O. Zhou, Hui Cheng, Junke Zheng, Tao Cheng
Summary: Reducing SEV production from endothelial cells significantly delays leukemia progression, without affecting normal hematopoiesis. These findings reveal a role of niche-specific SEVs in cancer development and suggest that targeting ANGPTL2-SEVs released from endothelial cells may be a potential strategy to interfere with certain types of AML.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Diana Sa da Bandeira, Alastair Morris Kilpatrick, Madalena Marques, Mario Gomez-Salazar, Telma Ventura, Zaniah Nashira Gonzalez, Dorota Stefancova, Fiona Rossi, Matthieu Vermeren, Chris Sebastiaan Vink, Mariana Beltran, Neil Cowan Henderson, Bongnam Jung, Reinier van der Linden, Harmen Jan George van de Werken, Wilfred F. J. van Ijcken, Christer Betsholtz, Stuart John Forbes, Henar Cuervo, Mihaela Crisan
Summary: This study reveals the expression of PDGFRβ in distinct perivascular stromal cell layers in mice and shows that its deletion impairs hematopoiesis. The study also demonstrates that PDGFRβ(+) cells play a dual role in murine hematopoiesis, acting as support for HSPCs in the aortic niche and giving rise to a subset of HSPCs that persist into adulthood.
Article
Multidisciplinary Sciences
Sabrina Summer, Eva Rossmanith, Markus Pasztorek, Constantin Fiedler, Marion Groeger, Sabine Rauscher, Viktoria Weber, Michael B. Fischer
Summary: Mesenchymal stem cells play a crucial role in supporting endothelial cells during tissue regeneration and new vessel formation. By co-culturing these cells in a specific microenvironment, complex vascular networks can be formed. Under dynamic flow conditions, mesenchymal stem cells can bind to damaged endothelial cells, potentially aiding in the healing process.
Review
Cell & Tissue Engineering
Hyun-Ji Park, Kenneth J. De Jesus Morales, Sruti Bheri, Brandon P. Kassouf, Michael E. Davis
Summary: This article summarizes the interactions between cardiac ECM and cells, focusing on their role in ischemic heart disease. It also highlights recent advances in native ECM-mimicking cardiac matrices as a platform for modulating cardiac cell behavior and inducing cardiac repair.
Review
Cell Biology
France Dierick, Julien Solinc, Juliette Bignard, Florent Soubrier, Sophie Nadaud
Summary: This review summarizes the importance of cellular processes and dysfunction in the development of pulmonary arterial hypertension, as well as the roles of circulating and resident vascular cells in pulmonary vascular remodeling.
Review
Cardiac & Cardiovascular Systems
Lisa Gross, Dirk Sibbing, Christian Schulz, Florian Gaertner, Joachim Pircher, Steffen Massberg, Tobias Petzold
CLINICAL RESEARCH IN CARDIOLOGY
(2018)
Article
Biochemical Research Methods
C. Stremmel, R. Schuchert, V Schneider, T. Weinberger, R. Thaler, D. Messerer, S. Helmer, F. Geissmann, J. Frampton, S. Massberg, C. Schulz
JOURNAL OF IMMUNOLOGICAL METHODS
(2018)
Article
Multidisciplinary Sciences
Julia Novotny, Sue Chandraratne, Tobias Weinberger, Vanessa Philippi, Konstantin Stark, Andreas Ehrlich, Joachim Pircher, Ildiko Konrad, Paul Oberdieck, Anna Titova, Qendresa Hoti, Irene Schubert, Kyle R. Legate, Nicole Urtz, Michael Lorenz, Jaroslav Pelisek, Steffen Massberg, Marie-Luise von Bruehl, Christian Schulz
Article
Multidisciplinary Sciences
Joachim Pircher, Thomas Czermak, Andreas Ehrlich, Clemens Eberle, Erik Gaitzsch, Andreas Margraf, Jochen Grommes, Prakash Saha, Anna Titova, Hellen Ishikawa-Ankerhold, Konstantin Stark, Tobias Petzold, Thomas Stocker, Ludwig T. Weckbach, Julia Novotny, Markus Sperandio, Bernhard Nieswandt, Alberto Smith, Hanna Mannell, Barbara Walzog, David Horst, Oliver Soehnlein, Steffen Massberg, Christian Schulz
NATURE COMMUNICATIONS
(2018)
Article
Neurosciences
Elisa Gomez Perdiguero, Christian Schulz, Frederic Geissmann
Review
Cell Biology
Andreas Meinhardt, Ming Wang, Christian Schulz, Sudhanshu Bhushan
JOURNAL OF LEUKOCYTE BIOLOGY
(2018)
Article
Hematology
Thomas J. Stocker, Joachim Pircher, Artid Skenderi, Andreas Ehrlich, Clemens Eberle, Remco T. A. Megens, Tobias Petzold, Zhe Zhang, Barbara Walzog, Annette Mueller-Taubenberger, Christian Weber, Steffen Massberg, Hellen Ishikawa-Ankerhold, Christian Schulz
THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Hematology
Christian Schulz, Olga von Beckerath, Rainer Okrojek, Nicolas von Beckerath, Steffen Massberg
THROMBOSIS JOURNAL
(2010)
Article
Hematology
Christian Schulz, Ildiko Konrad, Susanne Sauer, Lena Orschiedt, Maria Koellnberger, Reinhard Lorenz, Ulrich Walter, Steffen Massberg
THROMBOSIS AND HAEMOSTASIS
(2008)
Article
Hematology
Andreas Schaefer, Christian Schulz, Daniela Fraccarollo, Piet Tas, Meike Leutke, Martin Eigenthaler, Stefan Seidl, Peter Heider, Georg Ertl, Steffen Massberg, Johann Bauersachs
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2007)
Article
Hematology
S Massberg, S Gruner, I Konrad, MIG Arguinzonis, M Eigenthaler, K Hemler, J Kersting, C Schulz, I Muller, F Besta, B Nieswandt, U Heinzmann, U Walter, M Gawaz
