Single cell analysis of Crohn’s disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties

Contribution of ATOH1 + Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium

(2018) Fumiaki Ishibashi et al.   Stem Cell Reports

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

(2017) Wiebe Vanhove et al.   Journal of Crohns & Colitis

Hierarchy and Plasticity in the Intestinal Stem Cell Compartment

(2017) Maryam Yousefi et al.   TRENDS IN CELL BIOLOGY

Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology

(2017) Manuel Noben et al.   United European Gastroenterology Journal

Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs

(2016) Marcus A. F. Corat et al.   BLOOD

Investigating cell therapy for inflammatory bowel disease

(2016) Ryuichi Okamoto et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells

(2016) Ning Li et al.   GASTROENTEROLOGY

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

(2016) Jennifer Foulke-Abel et al.   GASTROENTEROLOGY

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes

(2016) Kengo Nozaki et al.   JOURNAL OF GASTROENTEROLOGY

A novel intestinal organoid-based in vitro co-culture system to dissect out the initial host defense system

(2016) Atsushi Mizoguchi   JOURNAL OF GASTROENTEROLOGY

Intestinal stem cell transplantation

(2016) Tetsuya Nakamura et al.   JOURNAL OF GASTROENTEROLOGY

Defining a stem cell hierarchy in the intestine: markers, caveats and controversies

(2016) Nicholas R. Smith et al.   JOURNAL OF PHYSIOLOGY-LONDON

The regulatory niche of intestinal stem cells

(2016) Badi Sri Sailaja et al.   JOURNAL OF PHYSIOLOGY-LONDON

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells

(2016) Satoru Fujii et al.   Scientific Reports

Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data

(2015) Lin Lin et al.   CYTOMETRY PART A

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology

(2015) Nicholas C. Zachos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease

(2015) Ryuichi Okamoto et al.   JOURNAL OF GASTROENTEROLOGY

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

(2015) Jason C. Mills et al.   Science Signaling

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

(2015) Jason C. Mills et al.   Science Signaling

Isolation of Human Colon Stem Cells Using Surface Expression of PTK7

(2015) Peter Jung et al.   Stem Cell Reports

Mapping early fate determination in Lgr5+ crypt stem cells using a novel Ki67-RFP allele

(2014) O. Basak et al.   EMBO JOURNAL

The workflow of single-cell expression profiling using quantitative real-time PCR

(2014) Anders Ståhlberg et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

(2014) Masayoshi Fukuda et al.   GENES & DEVELOPMENT

Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-Specific Function

(2014) Sabine Middendorp et al.   STEM CELLS

Single-Cell Analysis of Proxy Reporter Allele-Marked Epithelial Cells Establishes Intestinal Stem Cell Hierarchy

(2014) Ning Li et al.   Stem Cell Reports

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

Endoscopic Skipping of the Distal Terminal Ileum in Crohn's Disease Can Lead to Negative Results From Ileocolonoscopy

(2012) Sunil Samuel et al.   Clinical Gastroenterology and Hepatology

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

(2012) Javier Muñoz et al.   EMBO JOURNAL

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD

(2011) Michael Gersemann et al.   Journal of Crohns & Colitis

Single-cell dissection of transcriptional heterogeneity in human colon tumors

(2011) Piero Dalerba et al.   NATURE BIOTECHNOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

(2009) Laurens G. van der Flier et al.   GASTROENTEROLOGY

Requirement of Notch activation during regeneration of the intestinal epithelia

(2008) Ryuichi Okamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY