Review
Biochemistry & Molecular Biology
Hua-Min Zhang, Shuo Yuan, Huan Meng, Xiao-Ting Hou, Jiao Li, Jia-Chen Xue, You Li, Qi Wang, Ji-Xing Nan, Xue-Jun Jin, Qing-Gao Zhang
Summary: Inflammatory bowel disease (IBD) is a chronic, relapsing disease that greatly affects patients' quality of life. Stem cell therapy has shown potential to improve the clinical disease activity of patients with refractory IBD when conventional treatments are not effective, but its safety and long-term efficacy need further evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Qihang Hou, Jingxi Huang, Hammed Ayansola, Hori Masatoshi, Bingkun Zhang
Summary: The mammalian intestine is the largest immune organ, containing intestinal stem cells (ISC), differentiated epithelial cells, and gut resident-immune cells. Inflammatory bowel disease (IBD) threatens intestinal integrity and the continuous renewal of intestinal mucosal epithelium relies on ISC. Targeting inflamed mucosa healing may improve clinical symptoms and disease recurrence in IBD patients. Recent findings suggest that immune cells and cytokines play critical roles in ISC and intestinal epithelium regeneration, paving the way for new therapeutic approaches such as ISC transplantation. Integration of biological agents and ISC transplantation could revolutionize future therapy for IBD patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Guopu Chen, Fengyuan Wang, Min Nie, Hui Zhang, Han Zhang, Yuanjin Zhao
Summary: The newly developed roe-inspired microcapsules, providing sufficient nutrient supply and maintaining the functions of mesenchymal stem cells through core-shell structure, have the potential for clinical application in treating inflammatory bowel disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Huldani Huldani, Ria Margiana, Fawad Ahmad, Maria Jade Catalan Opulencia, Mohammad Javed Ansari, Dmitry Olegovich Bokov, Nargiza N. Abdullaeva, Homayoon Siahmansouri
Summary: Inflammatory bowel disease (IBD) is caused by various pathophysiologic pathways and immune-pathologic etiologies. Mesenchymal Stem Cells (MSCs) have been suggested as a potential treatment for IBD due to their immune regulatory functions. Clinical trials using MSCs from bone marrow, umbilical cord, and adipose tissue have shown promising results in terms of safety. However, further research is needed to obtain more reliable results and more support from laboratory evidence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Andrea Cassinotti, Francesco Passamonti, Sergio Segato
Summary: Cell-based therapies have been explored in immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD). The most studied treatment in IBD involves stem cells, with recent studies also focusing on regulatory cells such as T-reg and Tr1 cells. Preclinical research is also being conducted on induced pluripotent stem cells in animal models related to colitis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cell & Tissue Engineering
Teng Li, Chengxin Luo, Jiasi Zhang, Ling Wei, Wei Sun, Qin Xie, Yan Liu, Yongli Zhao, Shuangnian Xu, Lihua Wang
Summary: The co-infusion of mesenchymal stem cells (MSCs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) has shown improvement in engraftment and reduced risk of chronic graft-versus-host disease (cGVHD). However, the effects varied among different age and disease groups, suggesting potential benefits for certain populations.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Medicine, Research & Experimental
Ting Lin, Yunfan Yang, Xinchuan Chen
Summary: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for malignant hematological diseases. Mesenchymal stem cells (MSCs) play a role in promoting hematopoietic stem cell implantation and enhancing hematopoietic function reconstruction. They also show promise in preventing and treating graft-versus-host disease (GVHD), but larger randomized controlled trials are needed for validation. Factors such as dose, source, application time, and frequency need to be considered when using MSCs clinically.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Hongliang Yu, Xudong Yang, Xian Xiao, Meiqian Xu, Yanlei Yang, Chunling Xue, Xuechun Li, Shihua Wang, Robert Chunhua Zhao
Summary: The study suggests that exosomes derived from adipose mesenchymal stem cells have potential effectiveness in treating inflammatory bowel disease by promoting intestinal mucosa and epithelial cell regeneration, as well as maintaining intestinal integrity. This provides a theoretical basis for new therapeutic strategies involving cell-free therapy for IBD.
Article
Cell & Tissue Engineering
Murugadas Anbazhagan, Duke Geem, Suresh Venkateswaran, Ranjit Pelia, Vasantha L. Kolachala, Anne Dodd, Sushma C. Maddipatla, David J. Cutler, Jason D. Matthews, Raghavan Chinnadurai, Subra Kugathasan
Summary: Autologous intestinal MSCs from patients with inflammatory bowel disease (IBD) exhibit normal transcriptional and immunomodulatory properties, indicating their potential for cellular therapy.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Hideaki Fujiwara
Summary: This article discusses the impact of allo-HSCT on intestinal microbiota and metabolites, as well as the mechanisms for regulating experimental GVHD through dietary intervention or metabolites produced by intestinal bacteria post-allo-HSCT. It also summarizes the major findings of microbiome-based immunotherapeutic approaches for tissue protection against experimental GVHD. Understanding the complex relationships within the gut microbiota-metabolites-host tissues axis is crucial for insight into GVHD pathogenesis and the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ashley M. Nelson, Alexandra A. Erdmann, Christopher L. Coe, Mark B. Juckett, Keayra Morris, Jennifer M. Knight, Peiman Hematti, Erin S. Costanzo
Summary: Increased synthesis and release of inflammatory signalling proteins are common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT). This study examined the relationship between markers of inflammatory activity and depression symptoms following HCT. The results showed that patients with elevated levels of IL-6 and IL-10 reported more severe depression symptoms post-HCT, especially in terms of neurovegetative symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Cell & Tissue Engineering
Theresa Louise Boye, Casper Steenholdt, Kim Bak Jensen, Ole Haagen Nielsen
Summary: The pathogenesis of inflammatory bowel diseases (IBD) involves genetic predisposition, environmental factors, and dysregulated intestinal immune response. Treatment targets focus on mucosal and histological healing, but future therapies may involve molecular restoration using stem cell therapy.
Article
Cell & Tissue Engineering
Rashin Mohseni, Pouya Mahdavi Sharif, Maryam Behfar, Mohammad Reza Modaresi, Rohola Shirzadi, Mahta Mardani, Leila Jafari, Fahimeh Jafari, Zeynab Nikfetrat, Amir Ali Hamidieh
Summary: This study aimed to assess the safety and effectiveness of adipose tissue-derived mesenchymal stem cells (AT-MSCs) for pediatric patients with bronchiolitis obliterans syndrome (BoS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that a single injection of AT-MSCs partially improved the symptoms of patients and the treatment was safe and tolerable.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Immunology
Thomas Krueger, Rebekka Wehner, Maik Herbig, Martin Kraeter, Michael Kramer, Jan Moritz Middeke, Friedrich Stoelzel, Catrin List, Katharina Egger-Heidrich, Raphael Teipel, Uta Oelschlaegel, Martin Wermke, Helena Jambor, Manja Wobus, Johannes Schetelig, Korinna Joehrens, Torsten Tonn, Julien Subburayalu, Marc Schmitz, Martin Bornhauser, Malte von Bonin
Summary: Functional impairment of the bone marrow niche, particularly a decrease in mesenchymal stromal cells (MSCs), is associated with cytopenia and graft failure after hematopoietic cell transplantation. Acute graft-versus-host disease (aGvHD) is shown to significantly reduce MSC numbers, and this reduction can be observed before clinical onset of aGvHD. The different phenotypic and functional characteristics of MSCs depending on the occurrence of aGvHD suggest that they may contribute to alloreactivity after transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Takashi Nagaishi, Taro Watabe, Kunihiko Kotake, Toshihiko Kumazawa, Tomomi Aida, Kohichi Tanaka, Ryuichi Ono, Fumitoshi Ishino, Takako Usami, Takamasa Miura, Satomi Hirakata, Hiroko Kawasaki, Naoya Tsugawa, Daiki Yamada, Kazuhiro Hirayama, Soichiro Yoshikawa, Hajime Karasuyama, Ryuichi Okamoto, Mamoru Watanabe, Richard S. Blumberg, Takahiro Adachi
Summary: The study revealed that IgA plays a crucial role in mucosal homeostasis by regulating intestinal microbiota and protecting against mucosal inflammation, especially in the ileum. Mice lacking IgA showed spontaneous inflammation in the ileum and imbalanced intestinal microflora, while mice with IgA tail mutations appeared normal, suggesting the dispensability of the IgA cytoplasmic tail for preventing intestinal disorders.
Editorial Material
Gastroenterology & Hepatology
Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Sho Watanabe, Shuji Hibiya, Nobuhiro Katsukura, Sayuki Kitagawa, Ayako Sato, Ryuichi Okamoto, Mamoru Watanabe, Kiichiro Tsuchiya
Summary: This study is the first to reveal the mechanism and importance of telomere shortening in the pathogenesis of UC. Madecassoside (MD) could be a novel candidate for UC treatment beyond endoscopic mucosal healing.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Sakura Kirino, Nobuharu Tamaki, Masayuki Kurosaki, Shun Kaneko, Kento Inada, Yuki Tanaka, Shun Ishido, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Yuka Hayakawa, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Ryuichi Okamoto, Namiki Izumi
Summary: The aim of this study was to establish a target value of ALT level during NA treatment as a risk marker for HCC. The results showed that patients with ALT <21 IU/L at 1 year after NA initiation had a lower risk of HCC.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Eiko Saito, Kazuo Ohtsuka, Ami Kawamoto, Toshimitsu Fujii, Kento Takenaka, Shuji Hibiya, Hiromichi Shimizu, Masakazu Nagahori, Shohei Tomii, Ryuichi Okamoto
Summary: A 50-year-old man presented with abdominal pain and diarrhea persisting for 8 months, after being treated for myocarditis with ulceration in the gastrointestinal tract. Biopsy confirmed CMV gastrocolitis and antiviral therapy was given. Improvement was observed after discontinuation of eplerenone.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto
Summary: This study investigates the use of LRG as a biomarker for evaluating transmural activity in patients with Crohn's disease (CD). The results show a positive correlation between LRG levels and MRE scores, indicating that LRG is a highly accurate biomarker for detecting transmural activity in CD patients. Furthermore, high LRG levels are associated with increased risks of CD-related hospitalization, surgery, and clinical relapse.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ryuichi Okamoto, Tomohiro Mizutani, Hiromichi Shimizu
Summary: This article discusses the importance of mucosal healing in patients with IBD and introduces current factor-based or cell-based treatment options. It also explores the future prospects of regenerative medicine in the treatment of IBD.
Article
Gastroenterology & Hepatology
Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshihito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto
Summary: This study aimed to identify factors associated with immune-related liver injury (irLI) and investigate its impact on overall survival (OS) in patients treated with immune checkpoint inhibitors (ICIs). The results showed that treatment with anti-cytotoxic T-lymphocyte-associated protein-4 agents and baseline grade 1 aspartate aminotransferase/alanine aminotransferase elevation were independent predictive factors for grade >= 2 irLI. Treatment with anti-cytotoxic T-lymphocyte-associated protein-4 was the only independent predictive factor for grade >= 3 irLI. Patients who experienced any immune-related adverse events (irAEs) had a significantly longer median OS, and those with grade >= 2 irLI also had a significantly longer median OS. However, there was no significant difference in median OS between patients with grade >= 3 irLI and others.
HEPATOLOGY RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
Summary: This study aimed to explore the association between serum concentrations of biologics and transmural healing in patients with Crohn's disease. The results showed that patients who achieved transmural healing had a lower risk of hospitalization and surgery. Additionally, the concentration levels of drugs were found to be related to transmural healing.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto
Summary: Hepatitis C virus infection causes chronic liver inflammation and fibrogenesis, resulting in severe liver diseases and hepatocellular carcinoma. The presence of the virus in non-hepatic tissues can also lead to pathogenic impacts on extrahepatic systems and organs. These extrahepatic manifestations have significant effects on morbidity, mortality, and quality of life.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Taisei Keitoku, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Tsubasa Nobusawa, Hiroaki Matsumoto, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi
Summary: The significance of fatty liver in patients with chronic hepatitis B receiving nucleic acid analog therapy remains unclear. This study aimed to determine if fatty liver affects the development of hepatocellular carcinoma (HCC) in patients receiving NA therapy. The results showed that fatty liver was not a significant factor for HCC development in these patients, while advanced fibrosis was found to be an important risk factor.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Oncology
Shun Ishido, Kaoru Tsuchiya, Yoshihito Kano, Yutaka Yasui, Kenta Takaura, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada, Hiroaki Matsumoto, Tsubasa Nobusawa, Taisei Keitoku, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Hiroyuki Nakanishi, Urara Sakurai, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi
Summary: The clinical usefulness of comprehensive genomic profiling (CGP) in patients with unresectable hepatocellular carcinoma (HCC) who received multiple systemic therapies is investigated in this study. Gene alterations were detected in all nine patients, with seven being eligible for clinical trials based on CGP results. The median number of alterations per patient was four, and blood samples were used in patients with extrahepatic metastasis. These findings provide genomic information of patients with multiple systemic therapies and highlight the utility of blood samples in patients with extrahepatic metastasis. Furthermore, the study suggests that understanding the genomic status in patients treated with multiple molecular-targeted agents could lead to the development of newer systemic agents for HCC treatment.
Article
Physics, Applied
Takeya Unuma, Kosuke Ueda, Ryuichi Okamoto
Summary: We investigate how the initial energy distribution of electrons in a biased semiconductor superlattice, created by femtosecond pump pulses, affects terahertz Bloch oscillations. The emitted terahertz waveforms are well reproduced from a damped oscillation current with capacitive nature. In-plane excess energy changes the relaxation time via scattering processes, while partial use of the pump pulse spectrum reduces the temporal resolution.
APPLIED PHYSICS EXPRESS
(2023)
Article
Gastroenterology & Hepatology
Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui
Summary: This study focused on the role of sulfomucin in ulcerative colitis (UC) and found that sulfomucin production decreased in the inflammatory region of UC and increased in the distal colon and cecum of mice. Through organoids transplantation, sulfomucin secretion was restored in severely injured distal colon. This study provides a basis for the advancement of organoids transplantation therapy for refractory UC.
JOURNAL OF GASTROENTEROLOGY
(2023)
Correction
Gastroenterology & Hepatology
Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto
JOURNAL OF GASTROENTEROLOGY
(2023)