Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

(2017) Nike J. Kräutler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

IL-21 and IL-4 Collaborate To Shape T-Dependent Antibody Responses

(2015) H. M. McGuire et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and Morphological Properties of Germinal Center Dark ZoneCxcl12-Expressing Reticular Cells

(2015) Lauren B. Rodda et al.   JOURNAL OF IMMUNOLOGY

Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers

(2015) Myungsun Kang et al.   PLoS One

T cell help controls the speed of the cell cycle in germinal center B cells

(2015) A. D. Gitlin et al.   SCIENCE

Posttranscriptional control of the chemokine receptor CXCR4 expression in cancer cells

(2014) Norah Al-Souhibani et al.   CARCINOGENESIS

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

(2014) Sandra Zehentmeier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics

(2014) Radhika Goenka et al.   EXPERIMENTAL GERONTOLOGY

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

(2014) Viviana Cremasco et al.   NATURE IMMUNOLOGY

Dynamic signaling by T follicular helper cells during germinal center B cell selection

(2014) Z. Shulman et al.   SCIENCE

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

Germinal center B cells govern their own fate via antibody feedback

(2013) Yang Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation

(2013) Radhika Goenka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

(2012) G. D. Victora et al.   BLOOD

Affinity-based selection and the germinal center response

(2012) Tyani D. Chan et al.   IMMUNOLOGICAL REVIEWS

The establishment of the plasma cell survival niche in the bone marrow

(2012) Van T. Chu et al.   IMMUNOLOGICAL REVIEWS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Asymmetric Segregation of Polarized Antigen on B Cell Division Shapes Presentation Capacity

(2012) O. Thaunat et al.   SCIENCE

B Cell Receptor Signal Transduction in the GC Is Short-Circuited by High Phosphatase Activity

(2012) A. M. Khalil et al.   SCIENCE

A Theory of Germinal Center B Cell Selection, Division, and Exit

(2012) Michael Meyer-Hermann et al.   Cell Reports

Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts

(2011) Jennifer L. Marshall et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells

(2011) Sau K. Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eosinophils are required for the maintenance of plasma cells in the bone marrow

(2011) Van Trung Chu et al.   NATURE IMMUNOLOGY

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Development and Migration of Plasma Cells in the Mouse Lymph Node

(2010) David R. Fooksman et al.   IMMUNITY

IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

(2010) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+T cells

(2009) Oliver Dienz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature

(2009) E. Mohr et al.   JOURNAL OF IMMUNOLOGY

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties

(2008) Fabienne Mackay et al.   CYTOKINE & GROWTH FACTOR REVIEWS