Article
Oncology
Robert J. Motzer, Toni K. Choueiri, David F. McDermott, Thomas Powles, Yann-Alexandre Vano, Saurabh Gupta, Jin Yao, Celine Han, Ron Ammar, Simon Papillon-Cavanagh, Shruti S. Saggi, M. Brent McHenry, Petra Ross-Macdonald, Megan Wind-Rotolo
Summary: The study found that biomarkers previously associated with immune checkpoint inhibitor-containing regimens were not predictive for survival in RCC patients treated with nivolumab plus ipilimumab. However, gene expression analysis revealed an association between an inflammatory response and progression-free survival in patients receiving this treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Yang Li, Xiuli Lu, Zhihao Yu, Haozhen Wang, Bing Gao
Summary: In this study, it was found that ATP1A1 may be a key susceptibility gene involved in calcium stone formation. The down-regulation of ATP1A1 was associated with crystal deposition and activation of related signaling pathways. Overexpression of ATP1A1 or treatment with a specific inhibitor alleviated oxidative stress, inflammation, apoptosis, crystal-cell adhesion, and stone formation. These findings suggest that ATP1A1 could be a potential therapeutic target for treating calcium stones.
Article
Biochemistry & Molecular Biology
Orla Howe, Lisa White, Daniel Cullen, Grainne O'Brien, Laura Shields, Jane Bryant, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Brendan McClean, Aidan Meade, Christophe Badie, Fiona M. Lyng
Summary: Validation of a new 4-gene signature panel using G2 chromosomal radiosensitivity assay revealed significant differences in radiation response post-exposure, while some prostate cancer donors showed altered response due to Androgen Deprivation Therapy, suggesting intra-individual heterogeneity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xuelin Yao, Hanyuan Liu, Zhen Wang, Fangting Lu, Wenying Chen, Qing Feng, Yahu Miao, Jie Zhang, Yanlei Wang, Ye Chen, Liping Xue, Yehai Liu, Liang Chen, Qiu Zhang
Summary: Circular RNAs (circRNAs) play a crucial role in human cancer development, including papillary thyroid cancer (PTC). The circRNA circEIF3I is found to promote PTC progression by enhancing cell proliferation, cycle, migration, invasion, and in vivo cell proliferation. Mechanistically, circEIF3I interacts with AUF1 to stabilize Cyclin D1 mRNA and increase Cyclin D1 protein production. These findings highlight the significance of circEIF3I as a therapeutic target for PTC.
Article
Endocrinology & Metabolism
Canxiao Li, Jingting Li, Shijie Li, Yishen Zhao, Guandong Liu, Rui Du, Gianlorenzo Dionigi, Nan Liang, Hui Sun
Summary: This study found that LMR, PLR, MPV, and FIB could predict clinicopathologic features and recurrence in intermediate-to high-risk papillary thyroid carcinoma (PTC), with lower PLR being a potential risk factor for recurrence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Priya Debisarun, Katharina Goessling, Ozlem Bulut, Gizem Kilic, Martijn Zoodsma, Zhaoli Liu, Marina Oldenburg, Nadine Ruechel, Bowen Zhang, Cheng-Jian Xu, Patrick Struycken, Valerie A. C. M. N. Koeken, Jorge Dominguez-Andres, Simone J. C. F. M. Moorlag, Esther Taks, Philipp Ostermann, Lisa Mueller, Heiner Schaal, Ortwin Adams, Arndt G. Borkhardt, Jaap L. ten Oever, Reinout van Crevel, Yang L. Li, Mihai Netea
Summary: Influenza vaccination has been shown to reduce the risk of COVID-19 infection by decreasing systemic inflammation and reprogramming immune cells to fight against SARS-CoV-2. This suggests potential benefits of influenza vaccination against COVID-19, calling for future randomized trials to test this possibility.
Article
Environmental Sciences
Tanmoy Mondal, Christopher A. Loffredo, Tomas Trnovec, Lubica Palkovicova Murinova, Zarish Noreen, Thomas Nnanabu, Kamil Conka, Beata Drobna, Somiranjan Ghosh
Summary: This study investigates the effects of early-life PCB exposures on gene expression in young children. The results indicate significant alterations in several pathogenetic pathways, with an overall downregulation of selected genes. The downregulation of the LEPR gene is directly correlated with exposure variables, while gender and ethnicity also influence gene expression. This research highlights the importance of biomarker-based approaches in studying the genetic susceptibility to the effects of PCBs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Meiye Li, Jimei Zhang, Zongjing Zhang, Ying Qian, Wei Qu, Zhaoshun Jiang, Baochang Zhao
Summary: This study analyzed the infiltration level of immune cells in papillary thyroid cancer (PTC) using gene expression data and identified key modules and genes associated with immune cell infiltration. The results suggest that HCK, HLA-DRA, ITGB2, and TYROBP may serve as key diagnostic biomarkers and immunotherapy targets in PTC.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gita A. Pathak, Kritika Singh, Frank R. Wendt, Tyne W. Fleming, Cassie Overstreet, Dora Koller, Daniel S. Tylee, Flavio De Angelis, Brenda Cabrera Mendoza, Daniel F. Levey, Karestan C. Koenen, John H. Krystal, Robert H. Pietrzak, Christopher O' Donell, J. Michael Gaziano, Guido Falcone, Murray B. Stein, Joel Gelernter, Bogdan Pasaniuc, Nicholas Mancuso, Lea K. Davis, Renato Polimanti
Summary: This study investigates the biological heterogeneity of PTSD symptom clusters and identifies genes and miRNA families associated with PTSD. The analysis also highlights the importance of cyclooxygenase and acetylcholine compounds as potential drug targets. The study further explores the genetic correlation between PTSD and metabolic and laboratory traits. These findings provide comprehensive genomic evidence of comorbidities observed in epidemiological studies of PTSD.
MOLECULAR PSYCHIATRY
(2022)
Article
Genetics & Heredity
Ivan Petrini, Rocio L. Cecchini, Marilina Mascaro, Ignacio Ponzoni, Jessica A. Carballido
Summary: The likelihood of being diagnosed with thyroid cancer has increased in recent years. The aim of this study is to identify potential genes relevant to Papillary Thyroid Carcinoma (PTC) through bioinformatic analysis. Four genes, PTGFR, ZMAT3, GABRB2, and DPP6, were found to be highly relevant and worthy of further investigation.
Article
Medicine, General & Internal
Piotr Jozef Olbromski, Piotr Pawlik, Anna Bogacz, Stefan Sajdak
Summary: Ovarian cancer is a common cause of death among women worldwide. The current diagnostic and prognostic procedures available for the treatment of ovarian cancer are either not specific or are very expensive. This study evaluated the expression of selected genes and found that KRAS, NOXA, PUMA, c-FOS, and c-JUN may be associated with poor prognosis in ovarian cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anne-Christine Bay-Jensen, Asger Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Bente Juhl Riis, Claus Christiansen, Martin Michaelis, Hans Guehring, Christoph Ladel, Morten A. Karsdal
Summary: The study compared blood CRPM levels in OA and RA patients, finding that while the average levels were lower in OA patients compared to RA patients, a significant subset of OA patients had high CRPM levels similar to RA. Furthermore, OA patients with high CRPM levels were more likely to develop contra-lateral knee OA over a two-year follow-up period.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Steve E. Kalloger, Joanna M. Karasinska, Martin S. Keung, Danielle L. Thompson, Julie Ho, Christine Chow, Dongxia Gao, James T. Topham, Cassia Warren, Hui-Li Wong, Michael Kuan-Ching Lee, Daniel J. Renouf, David F. Schaeffer
Summary: The study examined the epithelial and stromal components in pancreatic ductal adenocarcinoma (PDAC) using laser capture microdissected (LCM) samples, revealing that the stromal component had independent prognostic differences. Specific gene expression differences in the epithelium and stroma may help improve prognostication for PDAC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Emily J. Howells, David Abrego, Yi Jin Liew, John A. Burt, Eli Meyer, Manuel Aranda
Summary: Research shows that corals thriving in extreme thermal environments can transfer heat tolerance genes to other populations to help them adapt to future climate warming. Selective breeding of corals with heat tolerance genes can significantly increase their survival rates.
Article
Dermatology
Poh-Ching Tan, Shuang-Bai Zhou, Min-Yi Ou, Ji-Zhou He, Pei-Qi Zhang, Xiao-Jie Zhang, Yun Xie, Yi-Ming Gao, Tian-Yu Zhang, Qing-Feng Li
Summary: This study demonstrates the effects of mechanical stretching on skin regeneration in humans, showing that it increases the population of papillary fibroblasts (Fp) and collagen synthesis, improves skin regeneration through the TGF beta 1/SMAD2/3 pathway, but long-term stretching can lead to premature Fp senescence and poor regeneration.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)