Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

(2021) Aliza P. Wingo et al.   NATURE GENETICS

Genome-wide association analyses of post-traumatic stress disorder and its symptom subdomains in the Million Veteran Program

(2021) Murray B. Stein et al.   NATURE GENETICS

Centrally acting anticholinergic drug trihexyphenidyl is highly effective in reducing nightmares associated with post‐traumatic stress disorder

(2021) Katsumasa Sogo et al.   Brain and Behavior

Targeting the endocannabinoid system in the treatment of PTSD: A promising case of preclinical-clinical translation?

(2021) Leah M. Mayo et al.   BIOLOGICAL PSYCHIATRY

Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?

(2021) Elisabetta Baldi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Craving Moderates the Effects of Intranasal Oxytocin on Anger in Response to Social Stress Among Veterans With Co-Occurring Posttraumatic Stress Disorder and Alcohol Use Disorder

(2021) Alexander J. Melkonian et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial

(2021) Krishna T. Patel et al.   NEUROPSYCHOPHARMACOLOGY

Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers

(2021) Nicole Mariani et al.   Translational Psychiatry

Saracatinib Fails to Reduce Alcohol-Seeking and Consumption in Mice and Human Participants

(2021) Summer L. Thompson et al.   Frontiers in Psychiatry

Posttraumatic Stress Disorder and Cardiovascular Disease

(2021) Christopher J. O’Donnell et al.   JAMA Cardiology

Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits

(2021) Jordi Merino et al.   Nature Human Behaviour

Increased prevalence of metabolic syndrome in Veterans with PTSD untreated with antipsychotic medications

(2021) Barton W. Palmer et al.   INTERNATIONAL JOURNAL OF MENTAL HEALTH

Attachment Style Moderates Polygenic Risk for Incident Posttraumatic Stress in U.S. Military Veterans: A 7-Year, Nationally Representative, Prospective Cohort Study

(2021) Amanda J.F. Tamman et al.   BIOLOGICAL PSYCHIATRY

Mining Clinical Data for Novel Posttraumatic Stress Disorder Medications

(2021) Brian Shiner et al.   BIOLOGICAL PSYCHIATRY

Effects of intranasal oxytocin on threat- and reward-related functional connectivity in men and women with and without childhood abuse-related PTSD

(2021) Lauren M. Sippel et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

(2020) Le Chang et al.   NUCLEIC ACIDS RESEARCH

Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics

(2020) Maya Ghoussaini et al.   NUCLEIC ACIDS RESEARCH

The impact of sex on gene expression across human tissues

(2020) Meritxell Oliva et al.   SCIENCE

PhenomeXcan: Mapping the genome to the phenome through the transcriptome

(2020) Milton Pividori et al.   Science Advances

Inflammation and posttraumatic stress disorder

(2019) Hiroaki Hori et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Common pathways and communication between the brain and heart: connecting post-traumatic stress disorder and heart failure

(2019) Marlene A. Wilson et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

(2019) Leah M. Mayo et al.   BIOLOGICAL PSYCHIATRY

Is there a relationship between PTSD and complicated obesity? A review of the literature

(2019) Jan Aaseth et al.   BIOMEDICINE & PHARMACOTHERAPY

A Bayesian framework for multiple trait colocalization from summary association statistics

(2018) Claudia Giambartolomei et al.   BIOINFORMATICS

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

(2018) Alexander Gusev et al.   NATURE GENETICS

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures

(2018) Andrew T. McKenzie et al.   Scientific Reports

Protective effects of elevated anandamide on stress and fear-related behaviors: translational evidence from humans and mice

(2018) Leah M. Mayo et al.   MOLECULAR PSYCHIATRY

Mediation and Moderation of the Relationship Between Combat Experiences and Post-Traumatic Stress Symptoms in Active Duty Military Personnel

(2017) Marshall Steele et al.   MILITARY MEDICINE

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability

(2017) L E Duncan et al.   MOLECULAR PSYCHIATRY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

TCSBN: a database of tissue and cancer specific biological networks

(2017) Sunjae Lee et al.   NUCLEIC ACIDS RESEARCH

Circulating miRNA associated with posttraumatic stress disorder in a cohort of military combat veterans

(2017) Christiana G. Martin et al.   PSYCHIATRY RESEARCH

Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity

(2017) Daniel Lindqvist et al.   PSYCHIATRY RESEARCH

Molecular indicators of stress-induced neuroinflammation in a mouse model simulating features of post-traumatic stress disorder

(2017) S Muhie et al.   Translational Psychiatry

Physical Interactions and Expression Quantitative Traits Loci Identify Regulatory Connections for Obesity and Type 2 Diabetes Associated SNPs

(2017) Tayaza Fadason et al.   Frontiers in Genetics

Posttraumatic stress disorder: A metabolic disorder in disguise?

(2016) Vasiliki Michopoulos et al.   EXPERIMENTAL NEUROLOGY

The association between post-traumatic stress disorder and lifetime DSM-5 psychiatric disorders among veterans: Data from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

(2016) Sharon M. Smith et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study

(2015) Daniel S. Tylee et al.   PSYCHONEUROENDOCRINOLOGY

Brain transcriptome profiles in mouse model simulating features of post-traumatic stress disorder

(2015) Seid Muhie et al.   Molecular Brain

Serum and amygdala microRNA signatures of posttraumatic stress: Fear correlation and biomarker potential

(2014) Nagaraja S. Balakathiresan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity

(2014) David S. Rowlands et al.   PHYSIOLOGICAL GENOMICS

Dysregulation in microRNA Expression Is Associated with Alterations in Immune Functions in Combat Veterans with Post-Traumatic Stress Disorder

(2014) Juhua Zhou et al.   PLoS One

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Transcriptional profiling of CD133+ cells in coronary artery disease and effects of exercise on gene expression

(2011) Delong Liu et al.   CYTOTHERAPY

PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

(2010) J. C. Denny et al.   BIOINFORMATICS

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways

(2010) Margarita Muiños-Gimeno et al.   BIOLOGICAL PSYCHIATRY