The pathogenetic role of β-cell mitochondria in type 2 diabetes

Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells

(2017) Lisa M. Nicholas et al.   Molecular Metabolism

Transcribing β-cell mitochondria in health and disease

(2017) Hindrik Mulder   Molecular Metabolism

Precise expression of Fis1 is important for glucose responsiveness of beta cells

(2016) Julia Schultz et al.   JOURNAL OF ENDOCRINOLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

The Pancreatic β-Cell: A Bioenergetic Perspective

(2016) David G. Nicholls   PHYSIOLOGICAL REVIEWS

Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells

(2015) A. A. Gerencser et al.   BIOCHEMICAL JOURNAL

Diabetes Susceptibility GenesPdx1andClec16aFunction in a Pathway Regulating Mitophagy in β-Cells

(2015) Scott A. Soleimanpour et al.   DIABETES

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

(2015) Kyle J Gaulton et al.   NATURE GENETICS

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism

(2015) Jessica R. Gooding et al.   Cell Reports

Genetics of Type 2 Diabetes—Pitfalls and Possibilities

(2015) Rashmi Prasad et al.   Genes

Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes

(2014) Vladimir V. Sharoyko et al.   HUMAN MOLECULAR GENETICS

Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release

(2013) Peter Spégel et al.   BIOCHEMICAL JOURNAL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Bridging the Gap Between Genetic Associations and Molecular Mechanisms for Type 2 Diabetes

(2013) Hui Jin Ng et al.   Current Diabetes Reports

Loss of Prohibitin Induces Mitochondrial Damages Altering  -Cell Function and Survival and Is Responsible for Gradual Diabetes Development

(2013) S. Supale et al.   DIABETES

Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells

(2013) Isabel Göhring et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetes in Friedreich Ataxia

(2013) Miriam Cnop et al.   JOURNAL OF NEUROCHEMISTRY

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

(2012) Miriam Cnop et al.   ANNALS OF NEUROLOGY

Diabetes Mellitus and the β Cell: The Last Ten Years

(2012) Frances M. Ashcroft et al.   CELL

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

(2012) J. J. Meier et al.   DIABETOLOGIA

Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells Do Not Require Glycolysis and Are Not Initiated by Fluctuations in Mitochondrial Bioenergetics

(2012) Isabel Goehring et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

(2011) Thomas Koeck et al.   Cell Metabolism

Reduced CytochromecIs an Essential Regulator of Sustained Insulin Secretion by Pancreatic Islets

(2011) Seung-Ryoung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

(2011) Andreas Wiederkehr et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells

(2011) Zhongyan Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Tissue-specific disallowance of housekeeping genes: The other face of cell differentiation

(2010) L. Thorrez et al.   GENOME RESEARCH

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Glucolipotoxicity of the pancreatic beta cell

(2009) Vincent Poitout et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Methylation of 12S rRNA Is Necessary for In Vivo Stability of the Small Subunit of the Mammalian Mitochondrial Ribosome

(2009) Metodi D. Metodiev et al.   Cell Metabolism

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

(2009) M. J. MacDonald et al.   DIABETOLOGIA

Persistent Oxidative Stress Due to Absence of Uncoupling Protein 2 Associated with Impaired Pancreatic β-Cell Function

(2009) Jingbo Pi et al.   ENDOCRINOLOGY

The molecular basis and clinical characteristics of Maternally Inherited Diabetes and Deafness (MIDD), a recently recognized diabetic subtype

(2009) J. A. Maassen et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Tight Coupling between Glucose and Mitochondrial Metabolism in Clonal β-Cells Is Required for Robust Insulin Secretion

(2009) Siri Malmgren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitochondrial dysfunction in pancreatic β-cells in Type 2 Diabetes

(2008) H MULDER et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS