Enzymatic detoxification: a sustainable means of degrading toxic organophosphate pesticides and chemical warfare nerve agents

The global burden of fatal self-poisoning with pesticides 2006-15: Systematic review

(2017) Emma J. Mew et al.   JOURNAL OF AFFECTIVE DISORDERS

Organophosphate pesticide exposure and neurodegeneration

(2016) Fernando Sánchez-Santed et al.   CORTEX

Polymeric biocatalytic membranes with immobilized thermostable phosphotriesterase

(2016) G. Vitola et al.   JOURNAL OF MEMBRANE SCIENCE

Functional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native Activity

(2016) Miriam Kaltenbach et al.   PLoS Genetics

Increased risk of attention-deficit/hyperactivity disorder associated with exposure to organophosphate pesticide in Taiwanese children

(2016) C.-J. Yu et al.   Andrology

Efficient Surface Display of Diisopropylfluorophosphatase (DFPase) in E. coli for Biodegradation of Toxic Organophosphorus Compounds (DFP and Cp)

(2015) Ali Mohammad Latifi et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Protein engineering of representative hydrolytic enzymes for remediation of organophosphates

(2015) Rupa Iyer et al.   BIOCHEMICAL ENGINEERING JOURNAL

Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX

(2015) Courtney M. Daczkowski et al.   BIOCHEMISTRY

An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination

(2015) Immacolata Del Giudice et al.   BIOTECHNOLOGY AND BIOENGINEERING

Secretory expression of organophosphorus hydrolase OPHC2 inYarrowia lipolyticaPolg

(2015) Meng Li et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES

A review of photochemical approaches for the treatment of a wide range of pesticides

(2015) P. Venkata Laxma Reddy et al.   JOURNAL OF HAZARDOUS MATERIALS

An Engineered Version of Human PON2 Opens the Way to Understand the Role of Its Post-Translational Modifications in Modulating Catalytic Activity

(2015) Luigi Mandrich et al.   PLoS One

Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia

(2015) Julien Hiblot et al.   Scientific Reports

Mesoporous titania thin films as efficient enzyme carriers for paraoxon determination/detoxification: effects of enzyme binding and pore hierarchy on the biocatalyst activity and reusability

(2014) N. Frančič et al.   ANALYST

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro

(2014) Franz Worek et al.   ARCHIVES OF TOXICOLOGY

Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent

(2014) Young-Su Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhancing Enzyme Stability by Construction of Polymer–Enzyme Conjugate Micelles for Decontamination of Organophosphate Agents

(2014) Nisaraporn Suthiwangcharoen et al.   BIOMACROMOLECULES

Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp

(2014) Xiao-Jing Luo et al.   BIOTECHNOLOGY AND BIOENGINEERING

Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane

(2014) Henning Hagmann et al.   FASEB JOURNAL

Improvement of organophosphorus hydrolase activity toward nerve agents by amino acid substitutions

(2014) Kosuke Nakayama et al.   Forensic Toxicology

Evaluation of genotoxic potential of commonly used organophosphate pesticides in peripheral blood lymphocytes of rats

(2014) A Ojha et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Characterization of a phosphotriesterase-like lactonase from the hyperthermoacidophilic crenarchaeon Vulcanisaeta moutnovskia

(2014) Verena Kallnik et al.   JOURNAL OF BIOTECHNOLOGY

A 5000-Fold Increase in the Specificity of a Bacterial Phosphotriesterase for Malathion through Combinatorial Active Site Mutagenesis

(2014) Tatheer Naqvi et al.   PLoS One

Engineering V-Type Nerve Agents Detoxifying Enzymes Using Computationally Focused Libraries

(2013) Izhack Cherny et al.   ACS Chemical Biology

Organophosphorus acid anhydrolase fromAlteromonas macleodii: structural study and functional relationship to prolidases

(2013) Andrea Štěpánková et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Bioremediation of pesticide contaminated water using an organophosphate degrading enzyme immobilized on nonwoven polyester textiles

(2013) Yuan Gao et al.   ENZYME AND MICROBIAL TECHNOLOGY

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

(2013) Monika M. Meier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic Neutralization of the Chemical Warfare Agent VX: Evolution of Phosphotriesterase for Phosphorothiolate Hydrolysis

(2013) Andrew N. Bigley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox

(2013) Julien Hiblot et al.   PLoS One

Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes

(2013) Guillaume Gotthard et al.   PLoS One

Central respiratory failure during acute organophosphate poisoning

(2013) Jennifer L. Carey et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

U.N. Taps Special Labs to Investigate Syrian Attack

(2013) M. Enserink   SCIENCE

Biocatalytic carbon nanotube paper: a ‘one-pot’ route for fabrication of enzyme-immobilized membranes for organophosphate bioremediation

(2013) Guy Mechrez et al.   Journal of Materials Chemistry B

Enhancing the Promiscuous Phosphotriesterase Activity of a Thermostable Lactonase (GkaP) for the Efficient Degradation of Organophosphate Pesticides

(2012) Yu Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Detoxification of G- and V-series nerve agents by the phosphotriesterase OpdA

(2012) Timo Wille et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents

(2012) Ping-Chuan Tsai et al.   BIOCHEMISTRY

Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling

(2012) Livnat Afriat-Jurnou et al.   BIOCHEMISTRY

Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid diisopropylfluorophosphatase

(2012) Tatyana Belinskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mn2+ modulates the kinetic properties of an archaeal member of the PLL family

(2012) Elena Porzio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus

(2012) Julien Hiblot et al.   PLoS One

A Further Biochemical Characterization of DrPLL the Thermophilic Lactonase from Deinococcus radiodurans

(2012) Luigi Mandrich et al.   PROTEIN AND PEPTIDE LETTERS

Characterisation of the organophosphate hydrolase catalytic activity of SsoPox

(2012) Julien Hiblot et al.   Scientific Reports

Thermostable Esterase 2 fromAlicyclobacillus acidocaldariusas Biosensor for the Detection of Organophosphate Pesticides

(2011) Ferdinando Febbraio et al.   ANALYTICAL CHEMISTRY

Destruction and Detection of Chemical Warfare Agents

(2011) Kibong Kim et al.   CHEMICAL REVIEWS

Catalytic detoxification

(2011) Frank M. Raushel   NATURE

Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

(2011) Rinkoo D Gupta et al.   Nature Chemical Biology

Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis

(2011) Michael Costante et al.   TOXICOLOGY IN VITRO

Improving the Catalytic Activity of HyperthermophilicPyrococcus horikoshiiProlidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures

(2011) Casey M. Theriot et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Improving the catalytic activity of hyperthermophilic Pyrococcus prolidases for detoxification of organophosphorus nerve agents over a broad range of temperatures

(2010) Casey M. Theriot et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Hydrolysis of organophosphorus compounds by microbial enzymes

(2010) Casey M. Theriot et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An intramolecular disulfide bond is required for the thermostability of methyl parathion hydrolase, OPHC2

(2010) Xiao-yu Chu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase

(2010) Luigia Merone et al.   BIORESOURCE TECHNOLOGY

Immobilization of organophosphate hydrolase on an amyloid fibril nanoscaffold: Towards bioremediation and chemical detoxification

(2010) Jared K. Raynes et al.   BIOTECHNOLOGY PROGRESS

Lactonases with oragnophosphatase activity: Structural and evolutionary perspectives

(2010) Dragomir I. Draganov   CHEMICO-BIOLOGICAL INTERACTIONS

Structural characterization of the catalytic calcium-binding site in diisopropyl fluorophosphatase (DFPase)—Comparison with related β-propeller enzymes

(2010) Marc-Michael Blum et al.   CHEMICO-BIOLOGICAL INTERACTIONS

In search of a catalytic bioscavenger for the prophylaxis of nerve agent toxicity

(2010) Robert C. diTargiani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers

(2010) Y. Ashani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

One Enzyme, Two Functions

(2010) Sebastian Altenhöfer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directed Evolution of a Thermostable Quorum-quenching Lactonase from the Amidohydrolase Superfamily

(2010) Jeng Yeong Chow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Rational Design of a Phosphotriesterase

(2009) C. J. Jackson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of two proline dipeptidases (prolidases) from the hyperthermophilic archaeon Pyrococcus horikoshii

(2009) Casey M. Theriot et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural basis for thermostability revealed through the identification and characterization of a highly thermostable phosphotriesterase-like lactonase from Geobacillus stearothermophilus

(2009) Renda Hawwa et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Evolution in the Amidohydrolase Superfamily: Substrate-Assisted Gain of Function in the E183K Mutant of a Phosphotriesterase-like Metal-Carboxylesterase

(2009) Luigi Mandrich et al.   BIOCHEMISTRY

Functional Annotation and Three-Dimensional Structure of Dr0930 fromDeinococcus radiodurans, a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily†‡

(2009) Dao Feng Xiang et al.   BIOCHEMISTRY

Structural Insights into the Dual Activities of the Nerve Agent Degrading Organophosphate Anhydrolase/Prolidase

(2009) Nand K. Vyas et al.   BIOCHEMISTRY

Structural determinants of the high thermal stability of SsoPox from the hyperthermophilic archaeon Sulfolobus solfataricus

(2009) Pompea Del Vecchio et al.   EXTREMOPHILES

A Common Mutation in Paraoxonase-2 Results in Impaired Lactonase Activity

(2009) David A. Stoltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based and Random Mutagenesis Approaches Increase the Organophosphate-Degrading Activity of a Phosphotriesterase Homologue from Deinococcus radiodurans

(2009) Renda Hawwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities

(2008) Mikael Elias et al.   JOURNAL OF MOLECULAR BIOLOGY

Organophosphorus-degrading bacteria: ecology and industrial applications

(2008) Brajesh K. Singh   NATURE REVIEWS MICROBIOLOGY

Catalytic methods for the destruction of chemical warfare agents under ambient conditions

(2007) Bryan M. Smith   CHEMICAL SOCIETY REVIEWS

In Crystallo Capture of a Michaelis Complex and Product-binding Modes of a Bacterial Phosphotriesterase

(2007) Colin J. Jackson et al.   JOURNAL OF MOLECULAR BIOLOGY