Article
Geriatrics & Gerontology
Yuki Enoki, Tomoya Nagai, Yuna Hamamura, Sumika Osa, Hideaki Nakamura, Kazuaki Taguchi, Hiroshi Watanabe, Toru Maruyama, Kazuaki Matsumoto
Summary: This study found that CKD-induced skeletal muscle atrophy is closely related to the Apj endogenous ligand-uremic toxin axis. It also demonstrated the potential therapeutic targeting of the apelin-Apj system for the management of skeletal muscle atrophy in CKD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Chemistry, Medicinal
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun
Summary: This study found that chronic infusion of apelin-13 does not change blood pressure or heart rate, and does not alter Ang II-induced hypertension and cardiac hypertrophy. These findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension.
Review
Medicine, General & Internal
Jiawei Song, Jianqiong Tang, Zhenzhou Zhang, Ying Liu, Jiuchang Zhong
Summary: The elabela/apelin-APJ axis plays a crucial role in regulating cardiovascular function in hypertension and has diverse effects on vascular tone. Understanding the elabela/apelin-APJ axis can help in the development of effective interventions for hypertension.
CHINESE MEDICAL JOURNAL
(2022)
Article
Immunology
Xu Wang, Lu Zhang, Peisen Li, Yafei Zheng, Yanjie Yang, Shaoping Ji
Summary: Apelin/APJ system plays an important role in physiological and pathophysiological situations, and can inhibit inflammatory response by regulating multiple pathways. It has been found to be involved in the development of various diseases, and deficiency or overabundance of apelin can aggravate disease states.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhe Chen, Qionglin Zhou, Jun Chen, Yiyuan Yang, Wei Chen, Hui Mao, Xueqian Ouyang, Kai Zhang, Mingzhu Tang, Jialong Yan, Linzhi Wang, Linxi Chen, Lanfang Li
Summary: This study demonstrates that apelin-13 stimulates VSMCs proliferation through MCU-dependent mitochondrial calcium uptake-induced mitophagy.
VASCULAR PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Cheng Li, Hongna Cheng, Binay Kumar Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang
Summary: This review summarizes the role of the Apelin-APJ system in diabetes and obesity, aiming to provide a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jingshun Luo, Wei Liu, Fen Feng, Linxi Chen
Summary: Apelin/APJ system has diverse effects on the locomotor system, promoting bone formation and muscle metabolism while exacerbating osteoarthritis and alleviating osteoporosis. Exercise-induced apelin may serve as a potent pharmacological agent for treating diseases and regulating physiological processes.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Shenghan Gao, Hongping Chen
Summary: Apelin and Elabela (Ela) are peptides that play crucial roles in the body by acting on their receptor APJ, not only impacting the endocrine system, but also promoting vascular development and maintaining myocardial cell homeostasis. This review explores their roles in the cardiovascular system, including their mechanisms in various cardiovascular diseases, and highlights the limited literature on their therapeutic potential. It also summarizes the regulatory pathways of the apelin/ELA-APJ axis in cardiovascular function and diseases, and includes the therapeutic effects of their analogues.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Tao Xu, Jian Jia, Na Xu, Chao Ye, Fen Zheng, Yan Yuan, Guo-Qing Zhu, Yi-Yang Zhan
Summary: In hypertensive rats, there is an increase in APJ expression and a decrease in apelin expression, while apelin-13 stimulates VSMC proliferation through APJ-mediated enhancement of autophagy. The effects of apelin-13 on VSMC proliferation can be blocked by the APJ antagonist F13A. Additionally, the autophagy inhibitor 3-MA can attenuate VSMC proliferation.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M. Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi
Summary: This study found that APL, an endogenous ligand for APJ, is upregulated in an acute colitis mouse model and in inflammatory bowel diseases (IBD) in humans. However, the mechanisms and functions of the APL/APJ axis in IBD are unclear. The researchers analyzed CD4+ T cells and found that APL expression was downregulated in the colonic tissue of a chronic colitis mouse model. Lack of APL resulted in decreased naive T cells and increased effecter T cells in secondary lymphoid organs. Administration of a synthetic APL peptide improved survival rate, lessened colitis severity, and decreased pro-inflammatory cytokine production.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yurong Wang, Yan Wang, Kai Xue, Feng Gao, Chengde Li, Hui Fang
Summary: The study showed that increased expression of Apelin-13 under chronic intermittent hypoxia conditions can reduce renal fibrosis, while inhibition of Apelin expression can exacerbate renal fibrosis. Cell experiments also demonstrated that Apelin-13 treatment can reduce oxidative stress and inflammatory response, and decrease the expression of fibrosis-related proteins.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Andrea L. Frump, Marjorie Albrecht, Bakhtiyor Yakubov, Sandra Breuils-Bonnet, Valerie Nadeau, Eve Tremblay, Francois Potus, Junichi Omura, Todd Cook, Amanda Fisher, Brooke Rodriguez, R. Dale Brown, Kurt R. Stenmark, C. Dustin Rubinstein, Kathy Krentz, Diana M. Tabima, Rongbo Li, Xin Sun, Naomi C. Chesler, Steeve Provencher, Sebastien Bonnet, Tim Lahm
Summary: This study identifies a novel cardioprotective mechanism in the right ventricle where 17β-estradiol upregulates apelin expression via estrogen receptor α, potentially leading to alleviation of RV failure induced by pulmonary arterial hypertension. Understanding and harnessing this E2/ERα/BMPR2/apelin axis may offer new RV-targeted therapies for PAH patients of both sexes.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Developmental Biology
Sandy Hanssens, Lucie Marousez, Oceane Pecheux, Capucine Besengez, Laurent Storme, Philippe Deruelle, Delphine Eberle, Jean Lesage
Summary: This study found that obesity reduces the levels of apelin in cord blood, but has no effect on maternal and cord blood levels of elabela or placental gene expression of this system.
Review
Cell Biology
Jiawei Chen, Zhiyue Li, Qun Zhao, Linxi Chen
Summary: This article reviews the role of the apelin/APJ system in the occurrence and development of various cancers, as well as its impact on angiogenesis, tumor stem cells, tumor microenvironment, drug resistance, and poor prognosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is the leading cause of cardiovascular disease worldwide, and it shares several risk factors with chronic kidney disease. Patients with chronic kidney disease are more susceptible to cardiovascular problems.
Review
Cell Biology
Lu He, Hong Zhou, Zhiqing Zeng, Hailun Yao, Weiping Jiang, Hongtao Qu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Lu He, Qionglin Zhou, Zheng Huang, Jin Xu, Hong Zhou, Deguan Lv, Liqun Lu, Shifang Huang, Mingzhu Tang, Jiuchang Zhong, Jian-xiong Chen, Xuling Luo, Lanfang Li, Linxi Chen
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Qionglin Zhou, Jin Xu, Meiqing Liu, Lu He, Kai Zhang, Yiyuan Yang, Xiao Yang, Hong Zhou, Mingzhu Tang, Liqun Lu, Zhe Chen, Linxi Chen, Lanfang Li
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Cell Biology
Yulan Dong, Qi Wang, Hailun Yao, Yawen Xiao, Jiaohong Wei, Peihan Xie, Jun Hu, Wen Chen, Yan Tang, Hong Zhou, Jincai Liu
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Neuroimaging
You-ming Zhang, Jian-ming Gao, Hong Zhou, Li Li, Li-zhi Liu, Zai-de Han, Xiao-ping Yi, Wei-hua Liao
BRAIN IMAGING AND BEHAVIOR
(2020)
Review
Medical Laboratory Technology
Hong Zhou, Lu He, Gaosheng Xu, Linxi Chen
CLINICA CHIMICA ACTA
(2020)
Article
Pharmacology & Pharmacy
Anbo Gao, Jin Zou, Zhenjiang Mao, Hong Zhou, Gaofeng Zeng
Summary: This study elucidates the mechanism by which ionizing radiation promotes hypertrophic cardiomyopathy by accelerating the activation of mitophagy through SUMO2-mediated SUMOylation of SH3GLB1, providing new treatment strategies and targets for preventing cardiovascular diseases caused by thoracic tumor radiotherapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hong Zhou, Jun Hu, Peihan Xie, Yulan Dong, Wen Chen, Huiting Wu, Yihong Jiang, Hao Lei, Guanghua Luo, Jincai Liu
Summary: This retrospective cohort study evaluated the joint effects of cerebral small vessel disease (CSVD)-related imaging biomarkers in patients with type 2 diabetes mellitus (T2DM) and cognitive impairment. The results showed a significant correlation between T2DM and cognitive impairment, with a joint effect of T2DM and lacunes on cognitive impairment.
Article
Multidisciplinary Sciences
Yueli Dai, Chenyu Ouyang, Guanghua Luo, Yi Cao, Jianchun Peng, Anbo Gao, Hong Zhou
Summary: This study investigates the use of machine learning techniques to predict the association between cardiovascular risk factors and coronary artery disease-reporting and data system (CAD-RADS) scores. By comparing different methods and analyzing feature importance, it was found that random forest (RF) and linear discriminant analysis (LDA) can accurately predict CAD-RADS scores.
Article
Cell Biology
Anbo Gao, Mengjie Wang, Xing Tang, Gangqing Shi, Kai Hou, Jinren Fang, Linlin Zhou, Hong Zhou, Weimin Jiang, Yukun Li, Fan Ouyang
Summary: Radiation-induced heart damage caused by low-dose X-rays leads to cardiac hypertrophy, and mitophagy activation plays a crucial role in this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Xinyu Xie, Xiaozhi Zhang, Shengcheng Ye, Dongping Xiong, Lijun Ouyang, Bin Yang, Hong Zhou, Yaping Wan
Summary: In this work, a new unsupervised multimodal medical image fusion framework that combines the Swin Transformer and CNN is proposed. The model effectively integrates multi-scale features and preserves more meaningful information through a two-stage training strategy and the RSCF module. Compared to other fusion methods, the proposed model demonstrates superior performance in qualitative and quantitative comparisons.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Review
Medical Laboratory Technology
Hong Zhou, Juan Yang, Peihan Xie, Yulan Dong, Yong You, Jincai Liu
CLINICA CHIMICA ACTA
(2017)