期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 906, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2021.174286
关键词
Apelin; APJ system; Locomotor system; Metabolism; Osteoarthritis; Osteoporosis
资金
- National Natural Science Foundation of China [81973326]
- Hunan Provincial Natural Science Foundation [2019JJ40255]
- Scientific Research Fund Project of Hunan Provincial Health Commission [20201901, 202102041763]
Apelin/APJ system has diverse effects on the locomotor system, promoting bone formation and muscle metabolism while exacerbating osteoarthritis and alleviating osteoporosis. Exercise-induced apelin may serve as a potent pharmacological agent for treating diseases and regulating physiological processes.
Apelin is an endogenous ligand of G protein-coupled receptor APJ. Apelin/APJ system is widely expressed in abundant tissues, especially bone, joint and muscle tissue. This review focus on the effects of apelin/APJ system on locomotor system. An increasing number of evidence suggests that apelin/APJ system plays a crucial role in many physiological and pathological processes of locomotor system. Physiologically, apelin/APJ system promotes bone formation, muscle metabolism and skeletal muscle production. Pathologically, apelin/APJ system exacerbates osteoarthritis pathogenesis, whereas it alleviates osteoporosis. Besides, the level of apelin expression is regulated by different training modes, including continuous aerobic exercise, high-intensity interval training and resistance exercises. More importantly, exercise-induced apelin may be a potent pharmacological agent for the treatment of diseases and the regulation of physiological processes. Considering the pleiotropic effects of apelin on locomotor system, apelin/APJ system may be an important therapeutic target for locomotor system diseases.
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